Polygenic Score (PGS) ID: PGS012576

Predicted Trait
Reported Trait Humoral IgG antibody response to EBV-EBNA1
Mapped Trait(s) Epstein Barr virus nuclear antigen 1 IgG measurement (EFO_0007790)
Released in PGS Catalog: June 17, 2026
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Score Details

Score Construction
PGS Name Ebna1_scorefile
Development Method
Name PRS-CSx
Parameters Baysean-continous shrinkage
Variants
Original Genome Build GRCh37
Number of Variants 723,164
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000811
Citation (link to publication) Namjou B et al. Front Genet (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
African: 100%
4,365 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90000522
Europe PMC: 32737300
 4,365 individuals Sub-Saharan African NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030725 PSS012267|
European Ancestry|
1,965 individuals
 PGP000811 |
Namjou B et al. Front Genet (2026)
 Reported Trait: Standardized EBNA1-IgG response OR: 1.56 [1.24, 1.95] AUROC: 0.65 R²: 0.06 age, sex, 10 PCs —
PPM030726 PSS012266|
European Ancestry|
954 individuals
 PGP000811 |
Namjou B et al. Front Genet (2026)
 Reported Trait: Standardized EBNA1-IgG response OR: 1.5 [1.06, 20.9] AUROC: 0.72 R²: 0.11 age, sex, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012266 The quantitative serologic IgG EBNA1- antibody response that has been previously measured in these cohort — 954 individuals — European — NR —
PSS012267 The quantitative serologic IgG EBNA1- antibody response that has been previously measured in these cohort — 1,965 individuals — European — UKB —