PGS Publication: PGP000811

Publication Information (EuropePMC)
Title Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response.
PubMed ID 41913744(Europe PMC)
doi 10.3389/fgene.2026.1786510
Publication Date March 16, 2026
Journal Front Genet
Author(s) Namjou B, Lape M, Weirauch MT, Kaufman KM, Kottyan LC.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012576
(Ebna1_scorefile)
 PGP000811 |
Namjou B et al. Front Genet (2026)
 Humoral IgG antibody response to EBV-EBNA1 Epstein Barr virus nuclear antigen 1 IgG measurement 723,164
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012576/ScoringFiles/PGS012576.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030725 PGS012576
(Ebna1_scorefile)
 PSS012267|
European Ancestry|
1,965 individuals
 PGP000811 |
Namjou B et al. Front Genet (2026)
 Reported Trait: Standardized EBNA1-IgG response OR: 1.56 [1.24, 1.95] AUROC: 0.65 R²: 0.06 age, sex, 10 PCs —
PPM030726 PGS012576
(Ebna1_scorefile)
 PSS012266|
European Ancestry|
954 individuals
 PGP000811 |
Namjou B et al. Front Genet (2026)
 Reported Trait: Standardized EBNA1-IgG response OR: 1.5 [1.06, 20.9] AUROC: 0.72 R²: 0.11 age, sex, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012266 The quantitative serologic IgG EBNA1- antibody response that has been previously measured in these cohort — 954 individuals — European — NR —
PSS012267 The quantitative serologic IgG EBNA1- antibody response that has been previously measured in these cohort — 1,965 individuals — European — UKB —