Polygenic Score (PGS) ID: PGS012577

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (MONDO_0004981)
Released in PGS Catalog: June 17, 2026
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Score Details

Score Construction
PGS Name GRS134_AF
Development Method
Name genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 134
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000812
Citation (link to publication) Chen Y et al. Eur J Psychotraumatol (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 91.4%
East Asian: 6.3%
African: 1.5%
Hispanic or Latin American: 0.9%
588,190 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006061
Europe PMC: 29892015
 8,967 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 36,792 individuals East Asian
(Japanese)		 NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 537,409 individuals European NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 5,022 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030728 PSS012268|
European Ancestry|
151,741 individuals
 PGP000812 |
Chen Y et al. Eur J Psychotraumatol (2024)
 Reported Trait: Incident atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 3.56 [3.26, 3.88] age, sex, ethnicity, assessment center, employment status, education level,Townsend Deprivation Index, smoking status, alcohol consumption status, physical activity, and healthy diet score —
PPM030727 PSS012268|
European Ancestry|
151,741 individuals
 PGP000812 |
Chen Y et al. Eur J Psychotraumatol (2024)
 Reported Trait: Incident atrial fibrillation x childhood maltreatment interaction — — Hazard ratio (HR, 3-5 childhood maltreatment and high PRS vs. no childhood maltreatment and low PRS): 5.31 [4.36, 6.48] age, sex, ethnicity, assessment centre, employment status, education level, Townsend Deprivation Index, smoking status, alcohol consumption status, physical activity, and healthy diet score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012268 — — 151,741 individuals,
43.4 % Male samples
 Mean = 55.8 years
Sd = 7.7 years		 European — UKB —