Polygenic Score (PGS) ID: PGS012580

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (MONDO_0004981)
Released in PGS Catalog: June 17, 2026
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Score Details

Score Construction
PGS Name PRS25_AF
Development Method
Name Genome-wide significant SNPs
Parameters R2 < 0.01
Variants
Original Genome Build NR
Number of Variants 25
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000814
Citation (link to publication) Zheng J et al. J Intern Med (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 89.9%
African: 4.4%
East Asian: 3.1%
Hispanic or Latin American: 2.5%
132,118 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • South Asian
  • African
  • East Asian
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004295
Europe PMC: 28416818
 4,130 individuals East Asian
(Japanese)		 NR
GWAS Catalog: GCST004295
Europe PMC: 28416818
 3,358 individuals Hispanic or Latin American NR
GWAS Catalog: GCST004295
Europe PMC: 28416818
 5,875 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST004295
Europe PMC: 28416818
 118,755 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030734 PSS012270|
Multi-ancestry (including European)|
453,102 individuals
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Reported Trait: Atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 1.83 [1.66, 2.0] major cardiovascular risk factors: Age, sex, ethnicity, the TDI, level of education, annual household income, BMI, smoking status, alcohol intake, physical activity (weekly metabolic equivalent minutes ≥600), vitamin supplementation, and comorbidities that may increase the risk of infections (i.e., hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012270 — — 425,676 individuals — European — UKB —
PSS012270 — — 8,639 individuals — South Asian — UKB —
PSS012270 — — 7,345 individuals — African American or Afro-Caribbean — UKB —
PSS012270 — — 1,462 individuals — East Asian
(Chinese)		 — UKB —
PSS012270 — — 9,980 individuals — Not reported — UKB —