PGS Publication: PGP000814

Publication Information (EuropePMC)
Title Association of hospital-treated infectious diseases and infection burden with cardiovascular diseases and life expectancy.
PubMed ID 38528394(Europe PMC)
doi 10.1111/joim.13780
Publication Date March 25, 2024
Journal J Intern Med
Author(s) Zheng J, Ni C, Lee SWR, Li FR, Huang J, Zhou R, Huang Y, Lip GYH, Wu X, Tang S.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012579
(PRS11_stroke)
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Stroke stroke disorder 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012579/ScoringFiles/PGS012579.txt.gz
PGS012581
(PRS169_CAD)
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Coronary artery disease coronary artery disorder 169
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012581/ScoringFiles/PGS012581.txt.gz
PGS012580
(PRS25_AF)
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Atrial fibrillation atrial fibrillation 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012580/ScoringFiles/PGS012580.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030734 PGS012580
(PRS25_AF)
 PSS012270|
Multi-ancestry (including European)|
453,102 individuals
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Reported Trait: Atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 1.83 [1.66, 2.0] major cardiovascular risk factors: Age, sex, ethnicity, the TDI, level of education, annual household income, BMI, smoking status, alcohol intake, physical activity (weekly metabolic equivalent minutes ≥600), vitamin supplementation, and comorbidities that may increase the risk of infections (i.e., hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease) —
PPM030735 PGS012581
(PRS169_CAD)
 PSS012270|
Multi-ancestry (including European)|
453,102 individuals
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Reported Trait: Coronary artery disease — — Hazard ratio (HR, high vs low tertile): 1.79 [1.72, 1.86] major cardiovascular risk factors: Age, sex, ethnicity, the TDI, level of education, annual household income, BMI, smoking status, alcohol intake, physical activity (weekly metabolic equivalent minutes ≥600), vitamin supplementation, and comorbidities that may increase the risk of infections (i.e., hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease) —
PPM030736 PGS012581
(PRS169_CAD)
 PSS012271|
Multi-ancestry (excluding European)|
27,426 individuals
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Reported Trait: Coronary artery disease x infectious disease interaction — — Hazard ratio (HR, with high infection and high PRS vs. no infection and low PRS): 3.41 [1.67, 5.28] sex, age (timescale), the Townsend Deprivation Index, level of education, annual household income, body mass index, smoking status, alcohol intake, physical activity, vitamin supplementation, hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease —
PPM030733 PGS012579
(PRS11_stroke)
 PSS012270|
Multi-ancestry (including European)|
453,102 individuals
 PGP000814 |
Zheng J et al. J Intern Med (2024)
 Reported Trait: Stroke — — Hazard ratio (HR, high vs low tertile): 1.61 [1.41, 1.82] major cardiovascular risk factors: Age, sex, ethnicity, the TDI, level of education, annual household income, BMI, smoking status, alcohol intake, physical activity (weekly metabolic equivalent minutes ≥600), vitamin supplementation, and comorbidities that may increase the risk of infections (i.e., hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012270 — — 425,676 individuals — European — UKB —
PSS012270 — — 8,639 individuals — South Asian — UKB —
PSS012270 — — 7,345 individuals — African American or Afro-Caribbean — UKB —
PSS012270 — — 1,462 individuals — East Asian
(Chinese)		 — UKB —
PSS012270 — — 9,980 individuals — Not reported — UKB —
PSS012271 — — 8,639 individuals — South Asian — UKB —
PSS012271 — — 7,345 individuals — African American or Afro-Caribbean — UKB —
PSS012271 — — 1,462 individuals — East Asian
(Chinese)		 — UKB —
PSS012271 — — 9,980 individuals — Not reported — UKB —