| Predicted Trait | |
| Reported Trait | Coronary artery disease |
| Mapped Trait(s) | coronary artery disorder (MONDO_0005010) |
| Score Construction | |
| PGS Name | PRS169_CAD |
| Development Method | |
| Name | Genome-wide significant SNPs |
| Parameters | R2 < 0.01 |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 169 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000814 |
| Citation (link to publication) | Zheng J et al. J Intern Med (2024) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
11,323 individuals | East Asian | NR |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
25,557 individuals | South Asian | NR |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
2,268 individuals | Greater Middle Eastern (Middle Eastern, North African or Persian) | NR |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
4,095 individuals | Hispanic or Latin American | NR |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
3,139 individuals | African American or Afro-Caribbean | NR |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
141,217 individuals | European | NR |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM030735 | PSS012270| Multi-ancestry (including European)| 453,102 individuals |
PGP000814 | Zheng J et al. J Intern Med (2024) |
Reported Trait: Coronary artery disease | — | — | Hazard ratio (HR, high vs low tertile): 1.79 [1.72, 1.86] | major cardiovascular risk factors: Age, sex, ethnicity, the TDI, level of education, annual household income, BMI, smoking status, alcohol intake, physical activity (weekly metabolic equivalent minutes ≥600), vitamin supplementation, and comorbidities that may increase the risk of infections (i.e., hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease) | — |
| PPM030736 | PSS012271| Multi-ancestry (excluding European)| 27,426 individuals |
PGP000814 | Zheng J et al. J Intern Med (2024) |
Reported Trait: Coronary artery disease x infectious disease interaction | — | — | Hazard ratio (HR, with high infection and high PRS vs. no infection and low PRS): 3.41 [1.67, 5.28] | sex, age (timescale), the Townsend Deprivation Index, level of education, annual household income, body mass index, smoking status, alcohol intake, physical activity, vitamin supplementation, hypertension, diabetes, high cholesterol, liver disease, kidney disease, and digestive disease | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012270 | — | — | 425,676 individuals | — | European | — | UKB | — |
| PSS012270 | — | — | 8,639 individuals | — | South Asian | — | UKB | — |
| PSS012270 | — | — | 7,345 individuals | — | African American or Afro-Caribbean | — | UKB | — |
| PSS012270 | — | — | 1,462 individuals | — | East Asian (Chinese) |
— | UKB | — |
| PSS012270 | — | — | 9,980 individuals | — | Not reported | — | UKB | — |
| PSS012271 | — | — | 8,639 individuals | — | South Asian | — | UKB | — |
| PSS012271 | — | — | 7,345 individuals | — | African American or Afro-Caribbean | — | UKB | — |
| PSS012271 | — | — | 1,462 individuals | — | East Asian (Chinese) |
— | UKB | — |
| PSS012271 | — | — | 9,980 individuals | — | Not reported | — | UKB | — |