Polygenic Score (PGS) ID: PGS012583

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal cancer (MONDO_0005575)
Released in PGS Catalog: June 17, 2026
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS141_CRC
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 141
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000817
Citation (link to publication) Tian Y et al. Br J Cancer (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 76%
East Asian: 22.8%
African: 1.2%
534,779 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002919
Europe PMC: 25990418
 17,556 individuals European NR
GWAS Catalog: GCST007856
Europe PMC: 30510241
 120,184 individuals European NR
GWAS Catalog: GCST007856
Europe PMC: 30510241
 5,294 individuals East Asian NR
GWAS Catalog: GCST000843
Europe PMC: 20972440
 7,962 individuals European NR
GWAS Catalog: GCST000168
Europe PMC: 18372901
 1,983 individuals European
(U.K.)		 NR
GWAS Catalog: GCST002411
Europe PMC: 24737748
 13,443 individuals European NR
GWAS Catalog: GCST003017
Europe PMC: 26151821
 37,955 individuals European NR
GWAS Catalog: GCST001792
Europe PMC: 23263487
 7,847 individuals East Asian NR
GWAS Catalog: GCST000053
Europe PMC: 17618284
 1,890 individuals European NR
GWAS Catalog: GCST000270
Europe PMC: 19011631
 3,831 individuals European NR
GWAS Catalog: GCST000113
Europe PMC: 17934461
 1,890 individuals European NR
GWAS Catalog: GCST007992
Europe PMC: 31089142
 92,967 individuals European NR
GWAS Catalog: GCST007552
Europe PMC: 30529582
 70,506 individuals East Asian NR
Europe PMC: 27005424
[
  • 1,172 cases
  • , 8,266 controls
]
 European
(Finnish)		 FINRISK, FTC, HBCS, Health2000
GWAS Catalog: GCST006131
Europe PMC: 29917119
 67,812 individuals European NR
Europe PMC: 14624392
 85 individuals European
(Ashkenazi Jews, Sephardi Jews, Arabs)		 MECC
GWAS Catalog: GCST001544
Europe PMC: 22634755
 17,780 individuals European NR
GWAS Catalog: GCST003799
Europe PMC: 26965516
 21,096 individuals East Asian NR
GWAS Catalog: GCST000169
Europe PMC: 18372905
 1,849 individuals European NR
GWAS Catalog: GCST002454
Europe PMC: 24836286
 8,270 individuals East Asian NR
GWAS Catalog: GCST002561
Europe PMC: 25105248
 6,424 individuals East Asian NR
GWAS Catalog: GCST002561
Europe PMC: 25105248
 6,596 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST003494
Europe PMC: 27145994
 2,329 individuals East Asian NR
Europe PMC: 21655089
[
  • 4,878 cases
  • , 4,914 controls
]
 European COGS, CoRGI

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030741 PSS012274|
European Ancestry|
28,486 individuals
 PGP000817 |
Tian Y et al. Br J Cancer (2024)
 Reported Trait: Colorectal cancer — — Odds ratio (OR, high vs low tertile): 2.87 [2.76, 2.99] age at the reference time, BMI, study, and the first three principal components to account for potential population substructure —
PPM030742 PSS012274|
European Ancestry|
28,486 individuals
 PGP000817 |
Tian Y et al. Br J Cancer (2024)
 Reported Trait: Colorectal cancer x menopausal hormone therapy interaction — — Odds ratio (OR, any MHT and high PRS vs. no MHT and low PRS): 1.83 [1.64, 2.04] age, BMI, study center, and the first three principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012274 — —
[
  • 11,519 cases
  • , 16,967 controls
]
,
0.0 % Male samples
 — European — 23 cohorts
  • CCFR
  • ,CLUEII
  • ,CORECT
  • ,CPSII
  • ,CRCGEN
  • ,DACHS
  • ,DALS
  • ,EPIC
  • ,ESTHER_VERDI
  • ,GECCO
  • ,LCCS
  • ,MCCS
  • ,MEC
  • ,MECC
  • ,NCCCS
  • ,NFCCR
  • ,NHS
  • ,PLCO
  • ,Samsung
  • ,UKB
  • ,USC
  • ,VITAL
  • ,WHI
 —