PGS Publication: PGP000817

Publication Information (EuropePMC)
Title Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk.
PubMed ID 38561434(Europe PMC)
doi 10.1038/s41416-024-02638-2
Publication Date April 1, 2024
Journal Br J Cancer
Author(s) Tian Y, Lin Y, Qu C, Arndt V, Baurley JW, Berndt SI, Bien SA, Bishop DT, Brenner H, Buchanan DD, Budiarto A, Campbell PT, Carreras-Torres R, Casey G, Chan AT, Chen R, Chen X, Conti DV, Díez-Obrero V, Dimou N, Drew DA, Figueiredo JC, Gallinger S, Giles GG, Gruber SB, Gunter MJ, Harlid S, Harrison TA, Hidaka A, Hoffmeister M, Huyghe JR, Jenkins MA, Jordahl KM, Joshi AD, Keku TO, Kawaguchi E, Kim AE, Kundaje A, Larsson SC, Marchand LL, Lewinger JP, Li L, Moreno V, Morrison J, Murphy N, Nan H, Nassir R, Newcomb PA, Obón-Santacana M, Ogino S, Ose J, Pardamean B, Pellatt AJ, Peoples AR, Platz EA, Potter JD, Prentice RL, Rennert G, Ruiz-Narvaez EA, Sakoda LC, Schoen RE, Shcherbina A, Stern MC, Su YR, Thibodeau SN, Thomas DC, Tsilidis KK, van Duijnhoven FJB, Van Guelpen B, Visvanathan K, White E, Wolk A, Woods MO, Wu AH, Peters U, Gauderman WJ, Hsu L, Chang-Claude J.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012583
(PRS141_CRC)
 PGP000817 |
Tian Y et al. Br J Cancer (2024)
 Colorectal cancer colorectal cancer 141
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012583/ScoringFiles/PGS012583.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030741 PGS012583
(PRS141_CRC)
 PSS012274|
European Ancestry|
28,486 individuals
 PGP000817 |
Tian Y et al. Br J Cancer (2024)
 Reported Trait: Colorectal cancer — — Odds ratio (OR, high vs low tertile): 2.87 [2.76, 2.99] age at the reference time, BMI, study, and the first three principal components to account for potential population substructure —
PPM030742 PGS012583
(PRS141_CRC)
 PSS012274|
European Ancestry|
28,486 individuals
 PGP000817 |
Tian Y et al. Br J Cancer (2024)
 Reported Trait: Colorectal cancer x menopausal hormone therapy interaction — — Odds ratio (OR, any MHT and high PRS vs. no MHT and low PRS): 1.83 [1.64, 2.04] age, BMI, study center, and the first three principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012274 — —
[
  • 11,519 cases
  • , 16,967 controls
]
,
0.0 % Male samples
 — European — 23 cohorts
  • CCFR
  • ,CLUEII
  • ,CORECT
  • ,CPSII
  • ,CRCGEN
  • ,DACHS
  • ,DALS
  • ,EPIC
  • ,ESTHER_VERDI
  • ,GECCO
  • ,LCCS
  • ,MCCS
  • ,MEC
  • ,MECC
  • ,NCCCS
  • ,NFCCR
  • ,NHS
  • ,PLCO
  • ,Samsung
  • ,UKB
  • ,USC
  • ,VITAL
  • ,WHI
 —