Polygenic Score (PGS) ID: PGS012585

Predicted Trait
Reported Trait Thyroid stimulating hormone levels
Mapped Trait(s) Thyroid stimulating hormone level (OBA_1000983)
Released in PGS Catalog: June 17, 2026
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Score Details

Score Construction
PGS Name PRSTSH
Development Method
Name Genome wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 59
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000820
Citation (link to publication) Kuś A et al. Thyroid (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
54,288 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006899
Europe PMC: 30367059
 54,288 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030749 PSS012278|
European Ancestry|
6,834 individuals
 PGP000820 |
Kuś A et al. Thyroid (2024)
 Reported Trait: TSH concentartion β: 0.0198 (0.0007) — — — —
PPM030750 PSS012277|
European Ancestry|
3,800 individuals
 PGP000820 |
Kuś A et al. Thyroid (2024)
 Reported Trait: TSH concentartion β: 0.0161 (0.0009) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012277 — — 3,800 individuals,
49.6 % Male samples
 Mean = 54.8 years
Sd = 18.0 years		 European — NBS —
PSS012278 — — 6,834 individuals,
48.4 % Male samples
 Mean = 65.2 years
Sd = 9.9 years		 European — RS —