PGS Publication: PGP000820

Publication Information (EuropePMC)
Title Towards Personalized TSH Reference Ranges: A Genetic and Population-Based Approach in Three Independent Cohorts.
PubMed ID 38919119(Europe PMC)
doi 10.1089/thy.2024.0045
Publication Date July 15, 2024
Journal Thyroid
Author(s) Kuś A, Sterenborg RBTM, Haug EB, Galesloot TE, Visser WE, Smit JWA, Bednarczuk T, Peeters RP, Åsvold BO, Teumer A, Medici M.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012585
(PRSTSH)
 PGP000820 |
Kuś A et al. Thyroid (2024)
 Thyroid stimulating hormone levels Thyroid stimulating hormone level 59
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012585/ScoringFiles/PGS012585.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030749 PGS012585
(PRSTSH)
 PSS012278|
European Ancestry|
6,834 individuals
 PGP000820 |
Kuś A et al. Thyroid (2024)
 Reported Trait: TSH concentartion β: 0.0198 (0.0007) — — — —
PPM030750 PGS012585
(PRSTSH)
 PSS012277|
European Ancestry|
3,800 individuals
 PGP000820 |
Kuś A et al. Thyroid (2024)
 Reported Trait: TSH concentartion β: 0.0161 (0.0009) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012277 — — 3,800 individuals,
49.6 % Male samples
 Mean = 54.8 years
Sd = 18.0 years		 European — NBS —
PSS012278 — — 6,834 individuals,
48.4 % Male samples
 Mean = 65.2 years
Sd = 9.9 years		 European — RS —