Polygenic Score (PGS) ID: PGS012589

Predicted Trait
Reported Trait Dementia
Mapped Trait(s) dementia (MONDO_0001627)
Released in PGS Catalog: June 17, 2026
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Score Details

Score Construction
PGS Name PRS29_dementia
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 29
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000823
Citation (link to publication) Zhang S et al. Int J Public Health (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
455,258 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007320
Europe PMC: 30617256
 455,258 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030762 PSS012285|
European Ancestry|
220,963 individuals
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Reported Trait: Incident dementia HR: 1.25 [1.21, 1.28] — — age, sex —
PPM030763 PSS012285|
European Ancestry|
220,963 individuals
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Reported Trait: Incident dementia (in APOE E4 homozygotes) HR: 8.64 [7.73, 9.67] — — age, sex APOE E4 dosage = 2
PPM030764 PSS012285|
European Ancestry|
220,963 individuals
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Reported Trait: Incident dementia x air pollution score interaction — — Hazard ratio (HR, high air pollution score and high PRS vs. low air pollution score and low PRS): 1.93 [1.6, 2.32] age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012285 — —
[
  • 3,385 cases
  • , 217,578 controls
]
,
44.1 % Male samples
 Mean = 59.9 years
Sd = 5.4 years		 European — UKB —