PGS Publication: PGP000823

Publication Information (EuropePMC)
Title Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort.
PubMed ID 38426188(Europe PMC)
doi 10.3389/ijph.2024.1606868
Publication Date Feb. 15, 2024
Journal Int J Public Health
Author(s) Zhang S, Cao H, Chen K, Gao T, Zhao H, Zheng C, Wang T, Zeng P, Wang K.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012589
(PRS29_dementia)
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Dementia dementia 29
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012589/ScoringFiles/PGS012589.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030762 PGS012589
(PRS29_dementia)
 PSS012285|
European Ancestry|
220,963 individuals
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Reported Trait: Incident dementia HR: 1.25 [1.21, 1.28] — — age, sex —
PPM030763 PGS012589
(PRS29_dementia)
 PSS012285|
European Ancestry|
220,963 individuals
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Reported Trait: Incident dementia (in APOE E4 homozygotes) HR: 8.64 [7.73, 9.67] — — age, sex APOE E4 dosage = 2
PPM030764 PGS012589
(PRS29_dementia)
 PSS012285|
European Ancestry|
220,963 individuals
 PGP000823 |
Zhang S et al. Int J Public Health (2024)
 Reported Trait: Incident dementia x air pollution score interaction — — Hazard ratio (HR, high air pollution score and high PRS vs. low air pollution score and low PRS): 1.93 [1.6, 2.32] age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012285 — —
[
  • 3,385 cases
  • , 217,578 controls
]
,
44.1 % Male samples
 Mean = 59.9 years
Sd = 5.4 years		 European — UKB —