Polygenic Score (PGS) ID: PGS019748

Predicted Trait
Reported Trait Fever of unknown origin
Mapped Trait(s) fever of unknown origin (EFO_0003952)
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name TPMI_783_LDpred2
Development Method
Name LDpred2
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 151,556
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000835
Citation (link to publication) Chen HH et al. Nature (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
330,955 individuals (100%)
Score Development/Training
East Asian: 100%
77,659 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 7,947 cases
  • , 323,008 controls
]
,
44.49 % Male samples
 East Asian
(Han Chinese)		 TPMI
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 1,802 cases
  • , 75,857 controls
]
,
45.98 % Male samples
 East Asian
(Han Chinese)		 TPMI 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037930 PSS013649|
East Asian Ancestry|
19,417 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Fever of unknown origin — AUROC: 0.65198 R²: 0.05105 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013649 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 —
[
  • 458 cases
  • , 18,959 controls
]
,
46.04 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —