Trait: fever of unknown origin

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003952
Description Fever in which the etiology cannot be ascertained.
Trait category
Other trait
Synonyms 2 synonyms
  • Unknown Origin Fever
  • Unknown Origin Fevers

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019747
(TPMI_783_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Fever of unknown origin fever of unknown origin 44
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019747/ScoringFiles/PGS019747.txt.gz
PGS019748
(TPMI_783_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Fever of unknown origin fever of unknown origin 151,556
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019748/ScoringFiles/PGS019748.txt.gz
PGS019749
(TPMI_783_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Fever of unknown origin fever of unknown origin 556,003
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019749/ScoringFiles/PGS019749.txt.gz
PGS019750
(TPMI_783_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Fever of unknown origin fever of unknown origin 983,825
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019750/ScoringFiles/PGS019750.txt.gz
PGS019751
(TPMI_783_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Fever of unknown origin fever of unknown origin 986,365
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019751/ScoringFiles/PGS019751.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037929 PGS019747
(TPMI_783_Lassosum2)
 PSS013650|
East Asian Ancestry|
19,417 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Fever of unknown origin — AUROC: 0.65195 R²: 0.05103 sex, age, array, PCs 1-10 —
PPM037930 PGS019748
(TPMI_783_LDpred2)
 PSS013649|
East Asian Ancestry|
19,417 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Fever of unknown origin — AUROC: 0.65198 R²: 0.05105 sex, age, array, PCs 1-10 —
PPM037931 PGS019749
(TPMI_783_MegaPRS)
 PSS013651|
East Asian Ancestry|
19,417 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Fever of unknown origin — AUROC: 0.65128 R²: 0.05068 sex, age, array, PCs 1-10 —
PPM037932 PGS019750
(TPMI_783_PRS-CS)
 PSS013652|
East Asian Ancestry|
19,417 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Fever of unknown origin — AUROC: 0.65131 R²: 0.05066 sex, age, array, PCs 1-10 —
PPM037933 PGS019751
(TPMI_783_SBayesR)
 PSS013653|
East Asian Ancestry|
19,417 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Fever of unknown origin — AUROC: 0.65134 R²: 0.05063 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013649 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 —
[
  • 458 cases
  • , 18,959 controls
]
,
46.04 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013650 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 —
[
  • 458 cases
  • , 18,959 controls
]
,
46.04 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013651 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 —
[
  • 458 cases
  • , 18,959 controls
]
,
46.04 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013652 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 —
[
  • 458 cases
  • , 18,959 controls
]
,
46.04 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013653 780.6, 995.86,R50.2, R50.81, R50.82, R50.9 —
[
  • 458 cases
  • , 18,959 controls
]
,
46.04 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —