Polygenic Score (PGS) ID: PGS019932

Predicted Trait
Reported Trait Insomnia
Mapped Trait(s) insomnia (MONDO_0013600)
Additional Trait Information Million Veteran Program electronic-health-record phenotype: at least one qualifying ICD-9 or ICD-10 insomnia diagnosis code; East Asian ancestry-specific score.
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name Insomnia MVP EAS
Development Method
Name PRS-CSx
Parameters Ancestry-specific posterior SNP effect sizes inferred using PRS-CSx; 1000 Genomes East Asian LD reference panel for the EAS component; HapMap target variants on GRCh38; a=1, b=0.5, phi=auto; other parameters default; no clumping or P-value thresholding.
Variants
Original Genome Build GRCh38
Number of Variants 1,021,391
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000836
Citation (link to publication) Wyss AB et al. Sleep (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
7,251 individuals (100%)

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90477492
 7,251 individuals East Asian MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information