Trait: insomnia

Trait Information
Identifier MONDO_0013600
Description A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep. [NCIT: P378]
Trait categories
Neurological disorder
Other disease
Synonyms 5 synonyms
  • DSPD
  • DSPS
  • delayed sleep phase syndrome, susceptibility to
  • insomnia
  • insomnia (disease)

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000908
(PRS_Insomnia)
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Insomnia insomnia 2,746,982
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000908/ScoringFiles/PGS000908.txt.gz
PGS001932
(portability-PLR_insomnia)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sleeplessness / insomnia insomnia 37,712
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001932/ScoringFiles/PGS001932.txt.gz
PGS002149
(portability-ldpred2_insomnia)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sleeplessness / insomnia insomnia 926,585
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002149/ScoringFiles/PGS002149.txt.gz
PGS003319
(ExPRSweb_Insomnia_1160_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 578,551
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003319/ScoringFiles/PGS003319.txt.gz
PGS003320
(ExPRSweb_Insomnia_1160_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 147
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003320/ScoringFiles/PGS003320.txt.gz
PGS003321
(ExPRSweb_Insomnia_1160_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 148
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003321/ScoringFiles/PGS003321.txt.gz
PGS003322
(ExPRSweb_Insomnia_1160_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 8,590,163
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003322/ScoringFiles/PGS003322.txt.gz
PGS003323
(ExPRSweb_Insomnia_1160_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 1,113,832
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003323/ScoringFiles/PGS003323.txt.gz
PGS003324
(ExPRSweb_Insomnia_1200_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 464,576
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003324/ScoringFiles/PGS003324.txt.gz
PGS003325
(ExPRSweb_Insomnia_1200_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 28,289
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003325/ScoringFiles/PGS003325.txt.gz
PGS003326
(ExPRSweb_Insomnia_1200_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 27,462
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003326/ScoringFiles/PGS003326.txt.gz
PGS003327
(ExPRSweb_Insomnia_1200_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 6,214,923
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003327/ScoringFiles/PGS003327.txt.gz
PGS003328
(ExPRSweb_Insomnia_1200_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Insomnia insomnia 1,065,129
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003328/ScoringFiles/PGS003328.txt.gz
PGS018976
(TPMI_327.41_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Organic or persistent insomnia insomnia 246,776
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018976/ScoringFiles/PGS018976.txt.gz
PGS018977
(TPMI_327.41_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Organic or persistent insomnia insomnia 939,879
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018977/ScoringFiles/PGS018977.txt.gz
PGS018978
(TPMI_327.41_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Organic or persistent insomnia insomnia 23,384
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018978/ScoringFiles/PGS018978.txt.gz
PGS018979
(TPMI_327.41_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Organic or persistent insomnia insomnia 983,818
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018979/ScoringFiles/PGS018979.txt.gz
PGS018980
(TPMI_327.41_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Organic or persistent insomnia insomnia 967,358
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018980/ScoringFiles/PGS018980.txt.gz
PGS019928
(Insomnia UKB)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Insomnia insomnia 1,069,748
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019928/ScoringFiles/PGS019928.txt.gz
PGS019929
(Insomnia MVP EUR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Insomnia insomnia 1,085,967
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019929/ScoringFiles/PGS019929.txt.gz
PGS019930
(Insomnia MVP AFR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Insomnia insomnia 1,211,512
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019930/ScoringFiles/PGS019930.txt.gz
PGS019931
(Insomnia MVP AMR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Insomnia insomnia 1,166,626
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019931/ScoringFiles/PGS019931.txt.gz
PGS019932
(Insomnia MVP EAS)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Insomnia insomnia 1,021,391
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019932/ScoringFiles/PGS019932.txt.gz
PGS019933
(Insomnia UKB+MVP EUR (meta-analyzed))
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Insomnia insomnia 1,116,570
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019933/ScoringFiles/PGS019933.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002950 PGS000908
(PRS_Insomnia)
 PSS001293|
European Ancestry|
5,713 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Sertraline takers OR: 1.06 [0.99, 1.14] — Variance explained (Nagelkerke's R2*100): 0.09 sex, age at study enrollment, genetic PCs 1-20 —
PPM002951 PGS000908
(PRS_Insomnia)
 PSS001289|
European Ancestry|
4,362 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Escitalopram takers OR: 1.12 [1.03, 1.21] — Variance explained (Nagelkerke's R2*100): 0.27 sex, age at study enrollment, genetic PCs 1-20 —
PPM002952 PGS000908
(PRS_Insomnia)
 PSS001294|
European Ancestry|
3,964 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Venlafaxine takers OR: 1.03 [0.95, 1.11] — Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20 —
PPM002953 PGS000908
(PRS_Insomnia)
 PSS001285|
European Ancestry|
1,655 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Amitriptyline takers OR: 1.28 [1.07, 1.52] — Variance explained (Nagelkerke's R2*100): 1.03 sex, age at study enrollment, genetic PCs 1-20 —
PPM002954 PGS000908
(PRS_Insomnia)
 PSS001291|
European Ancestry|
1,986 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Mirtazapine takers OR: 1.03 [0.88, 1.2] — Variance explained (Nagelkerke's R2*100): 0.01 sex, age at study enrollment, genetic PCs 1-20 —
PPM002955 PGS000908
(PRS_Insomnia)
 PSS001287|
European Ancestry|
2,523 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Desvenlafaxine takers OR: 1.13 [1.03, 1.25] — Variance explained (Nagelkerke's R2*100): 0.38 sex, age at study enrollment, genetic PCs 1-20 —
PPM002956 PGS000908
(PRS_Insomnia)
 PSS001286|
European Ancestry|
2,585 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Citalopram takers OR: 1.08 [0.96, 1.21] — Variance explained (Nagelkerke's R2*100): 0.12 sex, age at study enrollment, genetic PCs 1-20 —
PPM002957 PGS000908
(PRS_Insomnia)
 PSS001290|
European Ancestry|
3,665 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Fluoxetine takers OR: 1.03 [0.94, 1.13] — Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20 —
PPM002958 PGS000908
(PRS_Insomnia)
 PSS001288|
European Ancestry|
1,994 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Duloxetine takers OR: 1.14 [1.02, 1.28] — Variance explained (Nagelkerke's R2*100): 0.4 sex, age at study enrollment, genetic PCs 1-20 —
PPM002959 PGS000908
(PRS_Insomnia)
 PSS001292|
European Ancestry|
1,577 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Insomnia in Paroxetine takers OR: 1.16 [1.01, 1.33] — Variance explained (Nagelkerke's R2*100): 0.47 sex, age at study enrollment, genetic PCs 1-20 —
PPM010331 PGS001932
(portability-PLR_insomnia)
 PSS009419|
European Ancestry|
19,978 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1248 [0.1111, 0.1384] sex, age, birth date, deprivation index, 16 PCs —
PPM010332 PGS001932
(portability-PLR_insomnia)
 PSS009193|
European Ancestry|
4,116 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1003 [0.0699, 0.1305] sex, age, birth date, deprivation index, 16 PCs —
PPM010333 PGS001932
(portability-PLR_insomnia)
 PSS008747|
European Ancestry|
6,626 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1093 [0.0854, 0.133] sex, age, birth date, deprivation index, 16 PCs —
PPM010334 PGS001932
(portability-PLR_insomnia)
 PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0776 [0.0195, 0.1353] sex, age, birth date, deprivation index, 16 PCs —
PPM010335 PGS001932
(portability-PLR_insomnia)
 PSS008299|
South Asian Ancestry|
6,199 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0768 [0.052, 0.1015] sex, age, birth date, deprivation index, 16 PCs —
PPM010337 PGS001932
(portability-PLR_insomnia)
 PSS007863|
African Ancestry|
2,460 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0475 [0.0078, 0.087] sex, age, birth date, deprivation index, 16 PCs —
PPM010338 PGS001932
(portability-PLR_insomnia)
 PSS008967|
African Ancestry|
3,863 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.033 [0.0013, 0.0645] sex, age, birth date, deprivation index, 16 PCs —
PPM010336 PGS001932
(portability-PLR_insomnia)
 PSS008076|
East Asian Ancestry|
1,788 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0473 sex, age, birth date, deprivation index, 16 PCs —
PPM012040 PGS002149
(portability-ldpred2_insomnia)
 PSS009193|
European Ancestry|
4,116 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1208 [0.0905, 0.1508] sex, age, birth date, deprivation index, 16 PCs —
PPM012039 PGS002149
(portability-ldpred2_insomnia)
 PSS009419|
European Ancestry|
19,978 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1411 [0.1275, 0.1547] sex, age, birth date, deprivation index, 16 PCs —
PPM012041 PGS002149
(portability-ldpred2_insomnia)
 PSS008747|
European Ancestry|
6,626 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1253 [0.1015, 0.149] sex, age, birth date, deprivation index, 16 PCs —
PPM012042 PGS002149
(portability-ldpred2_insomnia)
 PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0852 [0.0271, 0.1427] sex, age, birth date, deprivation index, 16 PCs —
PPM012043 PGS002149
(portability-ldpred2_insomnia)
 PSS008299|
South Asian Ancestry|
6,199 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0985 [0.0737, 0.1231] sex, age, birth date, deprivation index, 16 PCs —
PPM012044 PGS002149
(portability-ldpred2_insomnia)
 PSS008076|
East Asian Ancestry|
1,788 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0345 [-0.0122, 0.081] sex, age, birth date, deprivation index, 16 PCs —
PPM012045 PGS002149
(portability-ldpred2_insomnia)
 PSS007863|
African Ancestry|
2,460 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0283 [-0.0114, 0.0679] sex, age, birth date, deprivation index, 16 PCs —
PPM012046 PGS002149
(portability-ldpred2_insomnia)
 PSS008967|
African Ancestry|
3,863 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0314 sex, age, birth date, deprivation index, 16 PCs —
PPM015908 PGS003319
(ExPRSweb_Insomnia_1160_LASSOSUM_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 0.978 [0.932, 1.028]
β: -0.0217 (0.025)		 AUROC: 0.498 [0.486, 0.51] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015911 PGS003320
(ExPRSweb_Insomnia_1160_PT_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 0.977 [0.937, 1.02]
β: -0.0228 (0.0218)		 AUROC: 0.494 [0.483, 0.505] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015909 PGS003321
(ExPRSweb_Insomnia_1160_PLINK_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 0.975 [0.934, 1.017]
β: -0.0258 (0.0218)		 AUROC: 0.493 [0.481, 0.505] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015907 PGS003322
(ExPRSweb_Insomnia_1160_DBSLMM_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 0.97 [0.931, 1.01]
β: -0.0309 (0.0206)		 AUROC: 0.492 [0.481, 0.504] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015910 PGS003323
(ExPRSweb_Insomnia_1160_PRSCS_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 0.988 [0.947, 1.031]
β: -0.0122 (0.0218)		 AUROC: 0.499 [0.487, 0.511] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015913 PGS003324
(ExPRSweb_Insomnia_1200_LASSOSUM_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 1.026 [0.985, 1.069]
β: 0.0254 (0.0209)		 AUROC: 0.507 [0.496, 0.518] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015916 PGS003325
(ExPRSweb_Insomnia_1200_PT_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 1.092 [1.048, 1.137]
β: 0.0876 (0.021)		 AUROC: 0.524 [0.512, 0.535] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015914 PGS003326
(ExPRSweb_Insomnia_1200_PLINK_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 1.085 [1.041, 1.131]
β: 0.0817 (0.021)		 AUROC: 0.522 [0.511, 0.534] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015912 PGS003327
(ExPRSweb_Insomnia_1200_DBSLMM_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 1.038 [0.997, 1.081]
β: 0.0375 (0.0206)		 AUROC: 0.51 [0.499, 0.521] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015915 PGS003328
(ExPRSweb_Insomnia_1200_PRSCS_MGI_20211120)
 PSS010009|
European Ancestry|
18,641 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Insomnia OR: 1.101 [1.056, 1.147]
β: 0.096 (0.021)		 AUROC: 0.524 [0.513, 0.536] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM037158 PGS018976
(TPMI_327.41_Lassosum2)
 PSS012869|
East Asian Ancestry|
17,271 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Organic or persistent insomnia — AUROC: 0.63693 R²: 0.03544 sex, age, array, PCs 1-10 —
PPM037159 PGS018977
(TPMI_327.41_LDpred2)
 PSS012868|
East Asian Ancestry|
17,271 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Organic or persistent insomnia — AUROC: 0.63767 R²: 0.03603 sex, age, array, PCs 1-10 —
PPM037160 PGS018978
(TPMI_327.41_MegaPRS)
 PSS012870|
East Asian Ancestry|
17,271 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Organic or persistent insomnia — AUROC: 0.63887 R²: 0.03647 sex, age, array, PCs 1-10 —
PPM037161 PGS018979
(TPMI_327.41_PRS-CS)
 PSS012871|
East Asian Ancestry|
17,271 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Organic or persistent insomnia — AUROC: 0.63737 R²: 0.03579 sex, age, array, PCs 1-10 —
PPM037162 PGS018980
(TPMI_327.41_SBayesR)
 PSS012872|
East Asian Ancestry|
17,271 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Organic or persistent insomnia — AUROC: 0.63665 R²: 0.03558 sex, age, array, PCs 1-10 —
PPM038108 PGS019928
(Insomnia UKB)
 PSS013823|
Multi-ancestry (including European)|
16,637 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC) OR: 1.17 [1.111, 1.22] — Incremental variance explained by the PRS for WHIIRS>=10: 0.27 [0.11, 0.48] Age, sex, study center, ancestry principal components; race additionally included in BHS. Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.69. HCHS/SOL analyses incorporated sampling weights.
PPM038109 PGS019929
(Insomnia MVP EUR)
 PSS013823|
Multi-ancestry (including European)|
16,637 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC) OR: 1.19 — — Age, sex, study center, ancestry principal components; race additionally included in BHS. European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.49. HCHS/SOL analyses incorporated sampling weights.
PPM038110 PGS019933
(Insomnia UKB+MVP EUR (meta-analyzed))
 PSS013823|
Multi-ancestry (including European)|
16,637 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC) OR: 1.27 — — Age, sex, study center, ancestry principal components; race additionally included in BHS. The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Significant between-study heterogeneity was observed (p for heterogeneity = 0.006); the manuscript also reports random-effects results. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008521 — — 1,153 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009419 — — 19,978 individuals — European UK (+ Ireland) UKB —
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 3,837 cases
  • , 8,144 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL Visit 1; survey-weighted analysis.
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 604 cases
  • , 1,465 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA Visit 5.
PSS013823 Modified 3-question WHIIRS score ≥6. —
[
  • 799 cases
  • , 721 controls
]
 — European — ARIC Visit 4 / Sleep Heart Health Study assessment.
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 410 cases
  • , 657 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — BHS_b BiCEPS visit.
PSS009193 — — 4,116 individuals — European Poland (NE Europe) UKB —
PSS008299 — — 6,199 individuals — South Asian India (South Asia) UKB —
PSS010009 PheCode 327.4 (http://phewascatalog.org/); Binary —
[
  • 2,830 cases
  • , 15,811 controls
]
 — European — MGI —
PSS008967 — — 3,863 individuals — African unspecified Nigeria (West Africa) UKB —
PSS012868 307.42, 327.0,F51.01, F51.03, F51.09 —
[
  • 1,195 cases
  • , 16,076 controls
]
,
46.44 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008076 — — 1,788 individuals — East Asian China (East Asia) UKB —
PSS012869 307.42, 327.0,F51.01, F51.03, F51.09 —
[
  • 1,195 cases
  • , 16,076 controls
]
,
46.44 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012870 307.42, 327.0,F51.01, F51.03, F51.09 —
[
  • 1,195 cases
  • , 16,076 controls
]
,
46.44 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012871 307.42, 327.0,F51.01, F51.03, F51.09 —
[
  • 1,195 cases
  • , 16,076 controls
]
,
46.44 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012872 307.42, 327.0,F51.01, F51.03, F51.09 —
[
  • 1,195 cases
  • , 16,076 controls
]
,
46.44 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS001285 — —
[
  • 140 cases
  • , 1,515 controls
]
 — European — AGDS —
PSS001286 — —
[
  • 367 cases
  • , 2,218 controls
]
 — European — AGDS —
PSS001287 — —
[
  • 488 cases
  • , 2,035 controls
]
 — European — AGDS —
PSS001288 — —
[
  • 382 cases
  • , 1,612 controls
]
 — European — AGDS —
PSS001289 — —
[
  • 712 cases
  • , 3,650 controls
]
 — European — AGDS —
PSS001290 — —
[
  • 582 cases
  • , 3,083 controls
]
 — European — AGDS —
PSS001291 — —
[
  • 186 cases
  • , 1,800 controls
]
 — European — AGDS —
PSS001292 — —
[
  • 235 cases
  • , 1,342 controls
]
 — European — AGDS —
PSS001293 — —
[
  • 1,018 cases
  • , 4,695 controls
]
 — European — AGDS —
PSS001294 — —
[
  • 793 cases
  • , 3,171 controls
]
 — European — AGDS —
PSS008747 — — 6,626 individuals — European Italy (South Europe) UKB —
PSS007863 — — 2,460 individuals — African American or Afro-Caribbean Carribean UKB —