Polygenic Score (PGS) ID: PGS019936

Predicted Trait
Reported Trait Excessive Daytime Sleepiness
Mapped Trait(s) excessive daytime sleepiness measurement (EFO_0007875)
Additional Trait Information Million Veteran Program phenotype: yes/no response to feeling excessively sleepy during the day, excluding regular naps; African ancestry-specific score.
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name Excessive Daytime Sleepiness MVP AFR
Development Method
Name PRS-CSx
Parameters Ancestry-specific posterior SNP effect sizes inferred using PRS-CSx; 1000 Genomes African LD reference panel for the AFR component; HapMap target variants on GRCh38; a=1, b=0.5, phi=auto; other parameters default; no clumping or P-value thresholding.
Variants
Original Genome Build GRCh38
Number of Variants 1,218,411
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000836
Citation (link to publication) Wyss AB et al. Sleep (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
African: 100%
35,362 individuals (100%)

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90479439
 35,362 individuals African American or Afro-Caribbean MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information