Trait: excessive daytime sleepiness measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007875
Description quantification of excessive daytime sleepiness such as how often it occurs and its severity
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019934
(Excessive Daytime Sleepiness UKB)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Excessive Daytime Sleepiness excessive daytime sleepiness measurement 1,116,191
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019934/ScoringFiles/PGS019934.txt.gz
PGS019935
(Excessive Daytime Sleepiness MVP EUR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Excessive Daytime Sleepiness excessive daytime sleepiness measurement 1,089,038
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019935/ScoringFiles/PGS019935.txt.gz
PGS019936
(Excessive Daytime Sleepiness MVP AFR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Excessive Daytime Sleepiness excessive daytime sleepiness measurement 1,218,411
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019936/ScoringFiles/PGS019936.txt.gz
PGS019937
(Excessive Daytime Sleepiness MVP AMR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Excessive Daytime Sleepiness excessive daytime sleepiness measurement 1,170,607
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019937/ScoringFiles/PGS019937.txt.gz
PGS019938
(Excessive Daytime Sleepiness MVP EAS)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Excessive Daytime Sleepiness excessive daytime sleepiness measurement 1,022,672
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019938/ScoringFiles/PGS019938.txt.gz
PGS019939
(Excessive Daytime Sleepiness UKB+MVP EUR (meta-analyzed))
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Excessive Daytime Sleepiness excessive daytime sleepiness measurement 1,116,797
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019939/ScoringFiles/PGS019939.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038111 PGS019934
(Excessive Daytime Sleepiness UKB)
 PSS013822|
Multi-ancestry (including European)|
16,767 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11) OR: 1.23 [1.16, 1.3] — Incremental variance explained by the PRS: 0.47 [0.25, 0.73] Age, sex, study center, ancestry principal components; race additionally included in BHS Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.83. HCHS/SOL analyses incorporated sampling weights.
PPM038112 PGS019935
(Excessive Daytime Sleepiness MVP EUR)
 PSS013822|
Multi-ancestry (including European)|
16,767 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11) OR: 1.15 [1.07, 1.24] — — Age, sex, study center, ancestry principal components; race additionally included in BHS. European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.29. HCHS/SOL analyses incorporated sampling weights.
PPM038113 PGS019939
(Excessive Daytime Sleepiness UKB+MVP EUR (meta-analyzed))
 PSS013822|
Multi-ancestry (including European)|
16,767 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11) OR: 1.12 — — Age, sex, study center, ancestry principal components; race additionally included in BHS. The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.11. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 1,905 cases
  • , 10,220 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL —
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 287 cases
  • , 1,786 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA —
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 431 cases
  • , 1,066 controls
]
 — European — ARIC —
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 169 cases
  • , 903 controls
]
 — European, African American or Afro-Caribbean
(European and Black/African American)		 — BHS_b —