Polygenic Score (PGS) ID: PGS019958

Predicted Trait
Reported Trait HbA1c
Mapped Trait(s) HbA1c measurement (EFO_0004541)
Released in PGS Catalog: Aug. 26, 2026
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Score Details

Score Construction
PGS Name GRS122_HbA1c
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 122
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000848
Citation (link to publication) Mandla R et al. Diabetes Care (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 68%
East Asian: 15.4%
Hispanic or Latin American: 7.1%
African: 5.1%
South Asian: 4.4%
215,974 individuals (100%)
PGS Evaluation
African: 33.3%
European: 33.3%
Multi-ancestry (including European): 33.3%
  • European
  • African
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90002247
Europe PMC: 34059833
 6,647 individuals African American or Afro-Caribbean Multiple
GWAS Catalog: GCST90002247
Europe PMC: 34059833
 33,307 individuals East Asian Multiple
GWAS Catalog: GCST90002247
Europe PMC: 34059833
 146,806 individuals European Multiple
GWAS Catalog: GCST90002247
Europe PMC: 34059833
 15,248 individuals Hispanic or Latin American Multiple
GWAS Catalog: GCST90002247
Europe PMC: 34059833
 9,525 individuals South Asian Multiple
GWAS Catalog: GCST90002247
Europe PMC: 34059833
 4,441 individuals Sub-Saharan African Multiple

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038158 PSS013851|
European Ancestry|
16,682 individuals
 PGP000848 |
Mandla R et al. Diabetes Care (2024)
 Reported Trait: HbA1c in G6PD non-carriets β: 0.06 (0.01) — — age, sex, diabetes status, and 10 principal components —
PPM038159 PSS013850|
African Ancestry|
6,672 individuals
 PGP000848 |
Mandla R et al. Diabetes Care (2024)
 Reported Trait: HbA1c β: 0.05 (0.02) — — age, sex, and 10 principal components —
PPM038160 PSS013850|
African Ancestry|
6,672 individuals
 PGP000848 |
Mandla R et al. Diabetes Care (2024)
 Reported Trait: HbA1c in G6PD non-carriets β: 0.05 (0.02) — — age, sex, and 10 principal components —
PPM038164 PSS013852|
Multi-ancestry (including European)|
29,828 individuals
 PGP000848 |
Mandla R et al. Diabetes Care (2024)
 Reported Trait: Diabetic retinopathy in diabetes OR: 0.82 (0.09) — — age, sex, ancestry PC, retinopathy risk factors, measured HbA1c —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013851 — — 16,682 individuals — European — AllofUs —
PSS013852 — — 3,282 individuals — European — AllofUs, UKB —
PSS013852 — — 26,546 individuals — African unspecified — AllofUs, UKB —
PSS013850 — — 6,672 individuals — African unspecified — AllofUs —