| Publication Information (EuropePMC) | |
| Title | Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries. |
| PubMed ID | 39042486(Europe PMC) |
| doi | 10.2337/dc23-1691 |
| Publication Date | Oct. 1, 2024 |
| Journal | Diabetes Care |
| Author(s) | Mandla R, Schroeder PH, Florez JC, Mercader JM, Leong A. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS019958 (GRS122_HbA1c) |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
HbA1c | HbA1c measurement | 122 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019958/ScoringFiles/PGS019958.txt.gz |
| PGS019959 (GRS14_HbA1c) |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
HbA1c | HbA1c measurement | 14 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019959/ScoringFiles/PGS019959.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM038158 | PGS019958 (GRS122_HbA1c) |
PSS013851| European Ancestry| 16,682 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: HbA1c in G6PD non-carriets | β: 0.06 (0.01) | — | — | age, sex, diabetes status, and 10 principal components | — |
| PPM038159 | PGS019958 (GRS122_HbA1c) |
PSS013850| African Ancestry| 6,672 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: HbA1c | β: 0.05 (0.02) | — | — | age, sex, and 10 principal components | — |
| PPM038160 | PGS019958 (GRS122_HbA1c) |
PSS013850| African Ancestry| 6,672 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: HbA1c in G6PD non-carriets | β: 0.05 (0.02) | — | — | age, sex, and 10 principal components | — |
| PPM038161 | PGS019959 (GRS14_HbA1c) |
PSS013850| African Ancestry| 6,672 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: HbA1c | β: 0.04 (0.02) | — | — | age, sex, diabetes status, and 10 principal components | — |
| PPM038162 | PGS019959 (GRS14_HbA1c) |
PSS013850| African Ancestry| 6,672 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: HbA1c in G6PD non-carriets | β: 0.05 (0.02) | — | — | age, sex, diabetes status, and 10 principal components | — |
| PPM038163 | PGS019959 (GRS14_HbA1c) |
PSS013853| African Ancestry| 26,546 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: Diabetic retinopathy in diabetes | OR: 0.41 (0.33) | — | — | age, sex, ancestry PC, retinopathy risk factors | — |
| PPM038164 | PGS019958 (GRS122_HbA1c) |
PSS013852| Multi-ancestry (including European)| 29,828 individuals |
PGP000848 | Mandla R et al. Diabetes Care (2024) |
Reported Trait: Diabetic retinopathy in diabetes | OR: 0.82 (0.09) | — | — | age, sex, ancestry PC, retinopathy risk factors, measured HbA1c | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS013850 | — | — | 6,672 individuals | — | African unspecified | — | AllofUs | — |
| PSS013851 | — | — | 16,682 individuals | — | European | — | AllofUs | — |
| PSS013852 | — | — | 3,282 individuals | — | European | — | AllofUs, UKB | — |
| PSS013852 | — | — | 26,546 individuals | — | African unspecified | — | AllofUs, UKB | — |
| PSS013853 | — | — | 26,546 individuals | — | African unspecified | — | AllofUs, UKB | — |