Polygenic Score (PGS) ID: PGS019960

Predicted Trait
Reported Trait Serum 25-Hydroxyvitamin D
Mapped Trait(s) vitamin D level (OBA_1000968)
Released in PGS Catalog: Aug. 26, 2026
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Score Details

Score Construction
PGS Name GRS62_25OH
Development Method
Name genome-wide significant SNPs
Parameters minor allele frequency >1%
Variants
Original Genome Build NR
Number of Variants 62
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000849
Citation (link to publication) Chen X et al. Am J Clin Nutr (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
443,734 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST010144
Europe PMC: 32059762
 443,734 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038165 PSS013854|
European Ancestry|
15,226 individuals
 PGP000849 |
Chen X et al. Am J Clin Nutr (2024)
 Reported Trait: Serum 25-Hydroxyvitamin D in type 2 diabetes β: 0.15 — — — —
PPM038166 PSS013854|
European Ancestry|
15,226 individuals
 PGP000849 |
Chen X et al. Am J Clin Nutr (2024)
 Reported Trait: Heart failure in type 2 diabetes HR: 0.93 [0.87, 1.0] — — age (continuous, years), sex (male or female), center (England, Scotland, or Wales), season of blood drawn (spring, summer, autumn, or winter), genotype measurement batch (UK BiLEVE array or UK Biobank Axiom array), and ten principal components of ancestry (continuous) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013854 — — 15,226 individuals,
61.0 % Male samples
 Mean = 59.3 years
Sd = 7.5 years		 European — UKB —