PGS Publication: PGP000849

Publication Information (EuropePMC)
Title Vitamin D and heart failure risk among individuals with type 2 diabetes: observational and Mendelian randomization studies.
PubMed ID 39053885(Europe PMC)
doi 10.1016/j.ajcnut.2024.07.019
Publication Date July 23, 2024
Journal Am J Clin Nutr
Author(s) Chen X, Xu J, Wan Z, Geng T, Zhu K, Li R, Lu Q, Lin X, Liu S, Ou Y, Yang K, An P, Manson JE, Liu G.
Released in PGS Catalog: Aug. 26, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019960
(GRS62_25OH)
 PGP000849 |
Chen X et al. Am J Clin Nutr (2024)
 Serum 25-Hydroxyvitamin D vitamin D level 62
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019960/ScoringFiles/PGS019960.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038165 PGS019960
(GRS62_25OH)
 PSS013854|
European Ancestry|
15,226 individuals
 PGP000849 |
Chen X et al. Am J Clin Nutr (2024)
 Reported Trait: Serum 25-Hydroxyvitamin D in type 2 diabetes β: 0.15 — — — —
PPM038166 PGS019960
(GRS62_25OH)
 PSS013854|
European Ancestry|
15,226 individuals
 PGP000849 |
Chen X et al. Am J Clin Nutr (2024)
 Reported Trait: Heart failure in type 2 diabetes HR: 0.93 [0.87, 1.0] — — age (continuous, years), sex (male or female), center (England, Scotland, or Wales), season of blood drawn (spring, summer, autumn, or winter), genotype measurement batch (UK BiLEVE array or UK Biobank Axiom array), and ten principal components of ancestry (continuous) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013854 — — 15,226 individuals,
61.0 % Male samples
 Mean = 59.3 years
Sd = 7.5 years		 European — UKB —