Polygenic Score (PGS) ID: PGS019999

Predicted Trait
Reported Trait Liver fat content
Mapped Trait(s) liver fat measurement (EFO_0010821)
Released in PGS Catalog: Oct. 23, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRSLF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 10
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000856
Citation (link to publication) Frostdahl H et al. Sci Rep (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
32,858 individuals (100%)
PGS Evaluation
European: 100%
8 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90016673
Europe PMC: 34128465
 32,858 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038255 PSS013895|
European Ancestry|
11,120 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content in moderate physical activity group — — Beta per 1-point higher GRSLF: 0.059 [0.048, 0.069] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038256 PSS013893|
European Ancestry|
9,105 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content in high physical activity group — — Beta per 1-point higher GRSLF: 0.065 [0.054, 0.077] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038261 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease — — OR per 1-point higher GRSLF: 1.17 [1.08, 1.27] age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038262 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease — — OR per 1-point higher GRSLF: 1.18 [1.11, 1.24] age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038263 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in low physical activity group — — OR per 1-point higher GRSLF: 1.07 [0.8, 1.42]
p: 0.669
beta per 1-point higher GRSLF: 0.004 [-0.012, 0.021]
p: 0.626		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038264 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in moderate physical activity group — — OR per 1-point higher GRSLF: 1.11 [0.97, 1.27]
p: 0.119
beta per 1-point higher GRSLF: 0.008 [-0.004, 0.02]
p: 0.211		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038265 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in high physical activity group — — OR per 1-point higher GRSLF: 1.41 [1.15, 1.73]
p: 0.001
beta per 1-point higher GRSLF: 0.012 [0.003, 0.021]
p: 0.008		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038266 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in low physical activity group — — OR per 1-point higher GRSLF: 1.27 [1.05, 1.54]
p: 0.016
beta per 1-point higher GRSLF: 0.035 [-0.001, 0.07]
p: 0.053		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038267 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in moderate physical activity group — — OR per 1-point higher GRSLF: 1.13 [1.02, 1.26]
p: 0.017
beta per 1-point higher GRSLF: 0.016 [0.002, 0.029]
p: 0.023		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038268 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in high physical activity group — — OR per 1-point higher GRSLF: 1.22 [1.06, 1.4]
p: 0.006
beta per 1-point higher GRSLF: 0.015 [0.004, 0.027]
p: 0.009		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038253 PSS013896|
European Ancestry|
23,080 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content — — R²: 0.053
Beta per 1-point higher GRSLF: 0.058 [0.052, 0.065]		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038254 PSS013894|
European Ancestry|
2,855 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content in low physical activity group — — Beta per 1-point higher GRSLF: 0.063 [0.041, 0.084] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013889 — — 239,308 individuals — European — UKB —
PSS013890 — — 98,691 individuals — European — UKB —
PSS013891 — — 28,253 individuals — European — UKB —
PSS013892 — — 112,364 individuals — European — UKB —
PSS013893 — — 9,105 individuals,
52.4 % Male samples
 Mean = 55.8 years
Sd = 7.6 years		 European — UKB —
PSS013894 — — 2,855 individuals,
52.5 % Male samples
 Mean = 54.7 years
Sd = 7.2 years		 European — UKB —
PSS013895 — — 11,120 individuals,
48.94 % Male samples
 Mean = 55.5 years
Sd = 7.4 years		 European — UKB —
PSS013896 — — 23,080 individuals — European — UKB —