PGS Publication: PGP000856

Publication Information (EuropePMC)
Title The interaction of genetics and physical activity in the pathogenesis of metabolic dysfunction associated liver disease.
PubMed ID 39090170(Europe PMC)
doi 10.1038/s41598-024-68271-4
Publication Date Aug. 1, 2024
Journal Sci Rep
Author(s) Frostdahl H, Ahmad N, Hammar U, Mora AM, Langner T, Fall T, Kullberg J, Ahlström H, Brooke HL, Ahmad S.
Released in PGS Catalog: Oct. 23, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019999
(GRSLF)
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Liver fat content liver fat measurement 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019999/ScoringFiles/PGS019999.txt.gz
PGS020000
(GRSLV)
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Liver volume liver volume 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS020000/ScoringFiles/PGS020000.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038255 PGS019999
(GRSLF)
 PSS013895|
European Ancestry|
11,120 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content in moderate physical activity group — — Beta per 1-point higher GRSLF: 0.059 [0.048, 0.069] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038256 PGS019999
(GRSLF)
 PSS013893|
European Ancestry|
9,105 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content in high physical activity group — — Beta per 1-point higher GRSLF: 0.065 [0.054, 0.077] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038257 PGS020000
(GRSLV)
 PSS013900|
European Ancestry|
20,986 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume — — R²: 0.016
Beta per 1-point higher GRSLV: 0.066 [0.059, 0.073]		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038258 PGS020000
(GRSLV)
 PSS013898|
European Ancestry|
2,605 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume in low physical activity group — — Beta per 1-point higher GRSLV: 0.066 [0.04, 0.092] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038259 PGS020000
(GRSLV)
 PSS013899|
European Ancestry|
10,089 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume in moderate physical activity group — — Beta per 1-point higher GRSLV: 0.063 [0.051, 0.074] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038260 PGS020000
(GRSLV)
 PSS013897|
European Ancestry|
8,292 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume in high physical activity group — — Beta per 1-point higher GRSLV: 0.067 [0.055, 0.079] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038261 PGS019999
(GRSLF)
 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease — — OR per 1-point higher GRSLF: 1.17 [1.08, 1.27] age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038262 PGS019999
(GRSLF)
 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease — — OR per 1-point higher GRSLF: 1.18 [1.11, 1.24] age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038263 PGS019999
(GRSLF)
 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in low physical activity group — — OR per 1-point higher GRSLF: 1.07 [0.8, 1.42]
p: 0.669
beta per 1-point higher GRSLF: 0.004 [-0.012, 0.021]
p: 0.626		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038264 PGS019999
(GRSLF)
 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in moderate physical activity group — — OR per 1-point higher GRSLF: 1.11 [0.97, 1.27]
p: 0.119
beta per 1-point higher GRSLF: 0.008 [-0.004, 0.02]
p: 0.211		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038265 PGS019999
(GRSLF)
 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in high physical activity group — — OR per 1-point higher GRSLF: 1.41 [1.15, 1.73]
p: 0.001
beta per 1-point higher GRSLF: 0.012 [0.003, 0.021]
p: 0.008		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038266 PGS019999
(GRSLF)
 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in low physical activity group — — OR per 1-point higher GRSLF: 1.27 [1.05, 1.54]
p: 0.016
beta per 1-point higher GRSLF: 0.035 [-0.001, 0.07]
p: 0.053		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038267 PGS019999
(GRSLF)
 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in moderate physical activity group — — OR per 1-point higher GRSLF: 1.13 [1.02, 1.26]
p: 0.017
beta per 1-point higher GRSLF: 0.016 [0.002, 0.029]
p: 0.023		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038268 PGS019999
(GRSLF)
 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in high physical activity group — — OR per 1-point higher GRSLF: 1.22 [1.06, 1.4]
p: 0.006
beta per 1-point higher GRSLF: 0.015 [0.004, 0.027]
p: 0.009		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038269 PGS020000
(GRSLV)
 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease — — OR per 1-point higher GRSLV: 1.14 [1.05, 1.24]
p: 0.001		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038270 PGS020000
(GRSLV)
 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease — — OR per 1-point higher GRSLV: 1.04 [0.98, 1.1]
p: 0.194		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038271 PGS020000
(GRSLV)
 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in low physical activity group — — OR per 1-point higher GRSLV: 1.16 [0.87, 1.55]
p: 0.309
beta per 1-point higher GRSLV: 0.01 [-0.011, 0.032]
p: 0.346		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038272 PGS020000
(GRSLV)
 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in moderate physical activity group — — OR per 1-point higher GRSLV: 1.11 [0.96, 1.27]
p: 0.158
beta per 1-point higher GRSLV: 0.007 [-0.003, 0.018]
p: 0.18		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038273 PGS020000
(GRSLV)
 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in high physical activity group — — OR per 1-point higher GRSLV: 1.16 [0.95, 1.43]
p: 0.15
beta per 1-point higher GRSLV: 0.006 [-0.002, 0.013]
p: 0.138		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038274 PGS020000
(GRSLV)
 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in low physical activity group — — OR per 1-point higher GRSLV: 0.96 [0.78, 1.17]
p: 0.662
beta per 1-point higher GRSLV: -0.007 [-0.037, 0.023]
p: 0.659		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038275 PGS020000
(GRSLV)
 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in moderate physical activity group — — OR per 1-point higher GRSLV: 0.99 [0.89, 1.1]
p: 0.806
beta per 1-point higher GRSLV: -0.001 [-0.015, 0.014]
p: 0.911		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038276 PGS020000
(GRSLV)
 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in high physical activity group — — OR per 1-point higher GRSLV: 1.05 [0.91, 1.21]
p: 0.507
beta per 1-point higher GRSLV: 0.004 [-0.006, 0.013]
p: 0.421		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038253 PGS019999
(GRSLF)
 PSS013896|
European Ancestry|
23,080 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content — — R²: 0.053
Beta per 1-point higher GRSLF: 0.058 [0.052, 0.065]		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038254 PGS019999
(GRSLF)
 PSS013894|
European Ancestry|
2,855 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver fat content in low physical activity group — — Beta per 1-point higher GRSLF: 0.063 [0.041, 0.084] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013898 — — 2,605 individuals,
53.07 % Male samples
 Mean = 54.6 years
Sd = 7.2 years		 European — UKB —
PSS013899 — — 10,089 individuals,
49.23 % Male samples
 Mean = 55.4 years
Sd = 7.4 years		 European — UKB —
PSS013900 — — 20,986 individuals — European — UKB —
PSS013889 — — 239,308 individuals — European — UKB —
PSS013890 — — 98,691 individuals — European — UKB —
PSS013891 — — 28,253 individuals — European — UKB —
PSS013892 — — 112,364 individuals — European — UKB —
PSS013893 — — 9,105 individuals,
52.4 % Male samples
 Mean = 55.8 years
Sd = 7.6 years		 European — UKB —
PSS013894 — — 2,855 individuals,
52.5 % Male samples
 Mean = 54.7 years
Sd = 7.2 years		 European — UKB —
PSS013895 — — 11,120 individuals,
48.94 % Male samples
 Mean = 55.5 years
Sd = 7.4 years		 European — UKB —
PSS013896 — — 23,080 individuals — European — UKB —
PSS013897 — — 8,292 individuals,
52.87 % Male samples
 Mean = 55.7 years
Sd = 7.5 years		 European — UKB —