Polygenic Score (PGS) ID: PGS020000

Predicted Trait
Reported Trait Liver volume
Mapped Trait(s) liver volume (OBA_2050033)
Released in PGS Catalog: Oct. 23, 2026
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Score Details

Score Construction
PGS Name GRSLV
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 11
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000856
Citation (link to publication) Frostdahl H et al. Sci Rep (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
32,860 individuals (100%)
PGS Evaluation
European: 100%
8 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90016666
Europe PMC: 34128465
 32,860 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038257 PSS013900|
European Ancestry|
20,986 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume — — R²: 0.016
Beta per 1-point higher GRSLV: 0.066 [0.059, 0.073]		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038258 PSS013898|
European Ancestry|
2,605 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume in low physical activity group — — Beta per 1-point higher GRSLV: 0.066 [0.04, 0.092] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038259 PSS013899|
European Ancestry|
10,089 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume in moderate physical activity group — — Beta per 1-point higher GRSLV: 0.063 [0.051, 0.074] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038260 PSS013897|
European Ancestry|
8,292 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Liver volume in high physical activity group — — Beta per 1-point higher GRSLV: 0.067 [0.055, 0.079] genotyping array, first 20 genetic principal components, age, sex, alcohol consumption (g/day), smoking status, Townsend deprivation index Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038269 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease — — OR per 1-point higher GRSLV: 1.14 [1.05, 1.24]
p: 0.001		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038270 PSS013889|
European Ancestry|
239,308 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease — — OR per 1-point higher GRSLV: 1.04 [0.98, 1.1]
p: 0.194		 age, sex, genotyping array, and population substructure Effect estimate is per 1-point increase in the unweighted GRS, not per SD.
PPM038271 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in low physical activity group — — OR per 1-point higher GRSLV: 1.16 [0.87, 1.55]
p: 0.309
beta per 1-point higher GRSLV: 0.01 [-0.011, 0.032]
p: 0.346		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038272 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in moderate physical activity group — — OR per 1-point higher GRSLV: 1.11 [0.96, 1.27]
p: 0.158
beta per 1-point higher GRSLV: 0.007 [-0.003, 0.018]
p: 0.18		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038273 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease in high physical activity group — — OR per 1-point higher GRSLV: 1.16 [0.95, 1.43]
p: 0.15
beta per 1-point higher GRSLV: 0.006 [-0.002, 0.013]
p: 0.138		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038274 PSS013891|
European Ancestry|
28,253 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in low physical activity group — — OR per 1-point higher GRSLV: 0.96 [0.78, 1.17]
p: 0.662
beta per 1-point higher GRSLV: -0.007 [-0.037, 0.023]
p: 0.659		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038275 PSS013892|
European Ancestry|
112,364 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in moderate physical activity group — — OR per 1-point higher GRSLV: 0.99 [0.89, 1.1]
p: 0.806
beta per 1-point higher GRSLV: -0.001 [-0.015, 0.014]
p: 0.911		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.
PPM038276 PSS013890|
European Ancestry|
98,691 individuals
 PGP000856 |
Frostdahl H et al. Sci Rep (2024)
 Reported Trait: Chronic liver disease in high physical activity group — — OR per 1-point higher GRSLV: 1.05 [0.91, 1.21]
p: 0.507
beta per 1-point higher GRSLV: 0.004 [-0.006, 0.013]
p: 0.421		 age, sex, first 20 genetic principal components, genotyping array, alcohol consumption (g/day), smoking status, Townsend deprivation index Betas and CI limits were multiplied by 100 and reported as percentages in the manuscript.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013898 — — 2,605 individuals,
53.07 % Male samples
 Mean = 54.6 years
Sd = 7.2 years		 European — UKB —
PSS013899 — — 10,089 individuals,
49.23 % Male samples
 Mean = 55.4 years
Sd = 7.4 years		 European — UKB —
PSS013900 — — 20,986 individuals — European — UKB —
PSS013889 — — 239,308 individuals — European — UKB —
PSS013890 — — 98,691 individuals — European — UKB —
PSS013891 — — 28,253 individuals — European — UKB —
PSS013892 — — 112,364 individuals — European — UKB —
PSS013897 — — 8,292 individuals,
52.87 % Male samples
 Mean = 55.7 years
Sd = 7.5 years		 European — UKB —