Polygenic Score (PGS) ID: PGS020003

Predicted Trait
Reported Trait Osteoporosis
Mapped Trait(s) osteoporosis (MONDO_0005298)
Released in PGS Catalog: Oct. 23, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS14_osteoporosis
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 14
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000861
Citation (link to publication) Yue YS et al. Osteoporos Int (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
426,795 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006980
Europe PMC: 30598549
 426,795 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038301 PSS013908|
East Asian Ancestry|
24,700 individuals
 PGP000861 |
Yue YS et al. Osteoporos Int (2024)
 Reported Trait: Incident osteoporosis OR: 1.44 [1.18, 1.77] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013908 — — 24,700 individuals,
48.1 % Male samples
 Mean = 68.4 years
Sd = 5.8 years		 East Asian — Kunshan —