Polygenic Score (PGS) ID: PGS020004

Predicted Trait
Reported Trait Abdominal aortic aneurysm
Mapped Trait(s) abdominal aortic aneurysm (MONDO_0005350)
Released in PGS Catalog: Oct. 23, 2026
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Score Details

Score Construction
PGS Name PRS22_AAA
Development Method
Name Genome-wide significant SNPs
Parameters minor allele frequency ≥0.05, missing rate <5%, Hardy-Weinberg Equilibrium ≥1.0 × 10−5, INFO score (information metric) of imputation >0.5, r2 < 0.5
Variants
Original Genome Build NR
Number of Variants 22
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000862
Citation (link to publication) Zhu D et al. JACC Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
104,830 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST003877
Europe PMC: 27899403
 104,830 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038302 PSS013909|
European Ancestry|
334,855 individuals
 PGP000862 |
Zhu D et al. JACC Adv (2024)
 Reported Trait: Incident Abdominal aortic aneurysm — — Hazard ratio (HR, high vs low tertile): 2.15 [1.89, 2.44] age, sex, Townsend Deprivation Index, history of hypertension, family history of heart disease, lifestyle factors (body mass index, smoking status, alcohol intake, and physical activity) —
PPM038303 PSS013909|
European Ancestry|
334,855 individuals
 PGP000862 |
Zhu D et al. JACC Adv (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x sleep pattern interaction — — Hazard ratio (HR, poor sleep pattern and high PRS vs. low sleep pattern and low PRS): 2.56 [1.78, 3.69] age, sex, Townsend Deprivation Index, history of hypertension, family history of heart disease, lifestyle factors (body mass index, smoking status, alcohol intake, and physical activity) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013909 — —
[
  • 16,222 cases
  • , 318,633 controls
]
 Mean = 63.49 years
Sd = 4.84 years		 European — UKB —