PGS Publication: PGP000862

Publication Information (EuropePMC)
Title Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants: Large-Scale Cohort Study.
PubMed ID 38938869(Europe PMC)
doi 10.1016/j.jacadv.2024.100967
Publication Date May 9, 2024
Journal JACC Adv
Author(s) Zhu D, Li X, Man Q, Zhao R, Zhang S, Han X, Jiang Y, Xu K, Chen X, Suo C, Xiong L.
Released in PGS Catalog: Oct. 23, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS020004
(PRS22_AAA)
 PGP000862 |
Zhu D et al. JACC Adv (2024)
 Abdominal aortic aneurysm abdominal aortic aneurysm 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS020004/ScoringFiles/PGS020004.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038302 PGS020004
(PRS22_AAA)
 PSS013909|
European Ancestry|
334,855 individuals
 PGP000862 |
Zhu D et al. JACC Adv (2024)
 Reported Trait: Incident Abdominal aortic aneurysm — — Hazard ratio (HR, high vs low tertile): 2.15 [1.89, 2.44] age, sex, Townsend Deprivation Index, history of hypertension, family history of heart disease, lifestyle factors (body mass index, smoking status, alcohol intake, and physical activity) —
PPM038303 PGS020004
(PRS22_AAA)
 PSS013909|
European Ancestry|
334,855 individuals
 PGP000862 |
Zhu D et al. JACC Adv (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x sleep pattern interaction — — Hazard ratio (HR, poor sleep pattern and high PRS vs. low sleep pattern and low PRS): 2.56 [1.78, 3.69] age, sex, Townsend Deprivation Index, history of hypertension, family history of heart disease, lifestyle factors (body mass index, smoking status, alcohol intake, and physical activity) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013909 — —
[
  • 16,222 cases
  • , 318,633 controls
]
 Mean = 63.49 years
Sd = 4.84 years		 European — UKB —