Trait: intracranial hemorrhage

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000551
Description Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
Trait category
Other trait
Synonyms 20 synonyms
  • Brain Hemorrhage
  • Brain Hemorrhages
  • HEMORRHAGE INTRACRANIAL
  • Hemorrhage, Brain
  • Hemorrhage, Intracranial
  • Hemorrhage, Posterior Fossa
  • Hemorrhages, Brain
  • Hemorrhages, Intracranial
  • Hemorrhages, Posterior Fossa
  • INTRACRANIAL HEMORR NOS
  • Intracranial Hemorrhage
  • Intracranial Hemorrhages
  • Intracranial haemorrhage
  • Intracranial haemorrhage NOS
  • Intracranial hemorrhage (disorder)
  • Intracranial hemorrhage, NOS
  • Posterior Fossa Hemorrhage
  • Posterior Fossa Hemorrhages
  • Unspecified intracranial hemorrhage
  • intracranial hemorrhage NOS (disorder)

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019215
(TPMI_430_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracranial hemorrhage intracranial hemorrhage 709,249
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019215/ScoringFiles/PGS019215.txt.gz
PGS019216
(TPMI_430_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracranial hemorrhage intracranial hemorrhage 939,872
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019216/ScoringFiles/PGS019216.txt.gz
PGS019217
(TPMI_430_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracranial hemorrhage intracranial hemorrhage 23,091
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019217/ScoringFiles/PGS019217.txt.gz
PGS019218
(TPMI_430_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracranial hemorrhage intracranial hemorrhage 983,811
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019218/ScoringFiles/PGS019218.txt.gz
PGS019219
(TPMI_430_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracranial hemorrhage intracranial hemorrhage 1,006,461
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019219/ScoringFiles/PGS019219.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037397 PGS019215
(TPMI_430_Lassosum2)
 PSS013123|
East Asian Ancestry|
17,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracranial hemorrhage — AUROC: 0.66064 R²: 0.01278 sex, age, array, PCs 1-10 —
PPM037398 PGS019216
(TPMI_430_LDpred2)
 PSS013122|
East Asian Ancestry|
17,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracranial hemorrhage — AUROC: 0.66428 R²: 0.01316 sex, age, array, PCs 1-10 —
PPM037399 PGS019217
(TPMI_430_MegaPRS)
 PSS013124|
East Asian Ancestry|
17,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracranial hemorrhage — AUROC: 0.65946 R²: 0.01257 sex, age, array, PCs 1-10 —
PPM037400 PGS019218
(TPMI_430_PRS-CS)
 PSS013125|
East Asian Ancestry|
17,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracranial hemorrhage — AUROC: 0.66105 R²: 0.01285 sex, age, array, PCs 1-10 —
PPM037401 PGS019219
(TPMI_430_SBayesR)
 PSS013126|
East Asian Ancestry|
17,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracranial hemorrhage — AUROC: 0.65968 R²: 0.01263 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013122 430, 431, 432,I60.0, I60.1, I60.2, I60.3, I60.4, I60.5, I60.6, I60.7, I60.8, I60.9, I61, I62.0, I62.1, I62.9 —
[
  • 236 cases
  • , 17,316 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013123 430, 431, 432,I60.0, I60.1, I60.2, I60.3, I60.4, I60.5, I60.6, I60.7, I60.8, I60.9, I61, I62.0, I62.1, I62.9 —
[
  • 236 cases
  • , 17,316 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013124 430, 431, 432,I60.0, I60.1, I60.2, I60.3, I60.4, I60.5, I60.6, I60.7, I60.8, I60.9, I61, I62.0, I62.1, I62.9 —
[
  • 236 cases
  • , 17,316 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013125 430, 431, 432,I60.0, I60.1, I60.2, I60.3, I60.4, I60.5, I60.6, I60.7, I60.8, I60.9, I61, I62.0, I62.1, I62.9 —
[
  • 236 cases
  • , 17,316 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013126 430, 431, 432,I60.0, I60.1, I60.2, I60.3, I60.4, I60.5, I60.6, I60.7, I60.8, I60.9, I61, I62.0, I62.1, I62.9 —
[
  • 236 cases
  • , 17,316 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —