Trait: myocardial infarction

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000612
Description Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. [NCIT: C27996]
Trait category
Cardiovascular disease
Synonyms 28 synonyms
  • Attack - heart
  • Cardiac infarction
  • Cardiac infarction, NOS
  • Heart attack, NOS
  • INFARCTION (MI), MYOCARDIAL
  • Infarct, Myocardial
  • Infarction of heart
  • Infarction of heart, NOS
  • Infarction, Myocardial
  • Infarctions, Myocardial
  • Infarcts, Myocardial
  • MI
  • MI - Myocardial infarction
  • MI, MYOCARDIAL INFARCTION
  • MI, myocardial infarction
  • MYOCARDIAL INFARCTION, (MI)
  • Myocardial Infarct
  • Myocardial Infarctions
  • Myocardial Infarcts
  • Myocardial infarction (disorder)
  • Myocardial infarction NOS
  • Myocardial infarction, NOS
  • heart attack
  • infarction (MI), myocardial
  • myocardial infarct
  • myocardial infarction
  • myocardial infarction (disease)
  • myocardial infarction, (MI)
Mapped term(s) 13 mapped terms
  • DOID:5844
  • HP:0001658
  • ICD10:I21
  • ICD10:I22
  • MESH:D009203
  • MONDO:0005068
  • MeSH:D009203
  • NCIT:C27996
  • NCIt:C27996
  • OMIM:608446
  • SCTID:22298006
  • SNOMEDCT:22298006
  • UMLS:C0027051

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000710
(HC326)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Myocardial infarction myocardial infarction 183,566
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000710/ScoringFiles/PGS000710.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001602 PGS000710
(HC326)
PSS000826|
European Ancestry|
87,413 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Myocardial infarction AUROC: 0.59348 Age, sex, PCs(1-10)
PPM001606 PGS000710
(HC326)
PSS000827|
European Ancestry|
135,300 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Myocardial infarction HR: 1.19 [1.17, 1.22] C-index: 0.707 Age as time scale, sex, batch, PCs(1-10)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000826 87,413 individuals European UKB
PSS000827 ICD-10 I21|I22
[
  • 7,913 cases
  • , 127,387 controls
]
European
(Finnish)
FinnGen