Trait: multiple myeloma

Experimental Factor Ontology (EFO) Information
Identifier EFO_0001378
Description A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001) [NCIT: C3242]
Trait category
Cancer
Immune system disorder
Synonyms 43 synonyms
  • Cell Myeloma, Plasma
  • Cell Myelomas, Plasma
  • Disease, Kahler
  • Kahler disease
  • Kahler's disease
  • MULT MYE W/O ACHV RMSON
  • MULT MYELM W/O REMISSION
  • Multiple Myelomas
  • Multiple myeloma (clinical)
  • Multiple myeloma (disorder)
  • Multiple myeloma without mention of having achieved remission
  • Multiple myeloma without mention of remission
  • Multiple myeloma, morphology (morphologic abnormality)
  • Multiple myeloma, no ICD-O subtype
  • Multiple myeloma, no ICD-O subtype (morphologic abnormality)
  • Myeloma
  • Myeloma Multiple
  • Myeloma, Multiple
  • Myeloma, NOS
  • Myeloma, Plasma Cell
  • Myeloma, Plasma-Cell
  • Myeloma-Multiple
  • Myeloma-Multiples
  • Myelomas, Multiple
  • Myelomas, Plasma Cell
  • Myelomas, Plasma-Cell
  • Myelomatoses
  • Myelomatosis
  • Plasma Cell Myeloma
  • Plasma Cell Myelomas
  • Plasma-Cell Myeloma
  • Plasma-Cell Myelomas
  • Plasmacytic myeloma
  • [M]Plasma cell myeloma
  • medullary plasmacytoma
  • multiple myeloma
  • multiple myeloma/plasma cell myeloma
  • myeloid neoplasm of plasma cell
  • myeloma
  • myeloma, plasma cell, malignant
  • myelomatosis
  • plasma cell myeloid neoplasm
  • plasma cell myeloma
Mapped term(s) 20 mapped terms
  • COHD:437233
  • DOID:9538
  • GARD:0007108
  • ICD10:C90
  • ICD10:C90.0
  • ICD10:C90.00
  • ICD9:203.0
  • ICDO:9732/3
  • MESH:D009101
  • MONDO:0009693
  • MeSH:D009101
  • MedDRA:10028228
  • NCIT:C3242
  • NCIt:C3242
  • OMIM:254500
  • ONCOTREE:PCM
  • Orphanet:29073
  • SNOMEDCT:109989006
  • SNOMEDCT:55921005
  • UMLS:C0026764

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000652
(PRSWEB_PHECODE204.4_C90_PT_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Multiple myeloma multiple myeloma 27
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000652/ScoringFiles/PGS000652.txt.gz
PGS000653
(PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Multiple myeloma multiple myeloma 22
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000653/ScoringFiles/PGS000653.txt.gz
PGS000654
(PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Multiple myeloma multiple myeloma 21
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000654/ScoringFiles/PGS000654.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001339 PGS000654
(PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608)
PSS000582|
European Ancestry|
2,738 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Multiple myeloma OR: 1.316 [1.156, 1.499]
β: 0.275 (0.0662)
AUROC: 0.576 [0.536, 0.616] Nagelkerke's Pseudo-R²: 0.0137
Brier score: 0.0818
Odds Ratio (OR, top 1% vs. Rest): 2.2 [0.854, 5.66]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_PT_UKB_20200608
PPM001338 PGS000653
(PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608)
PSS000582|
European Ancestry|
2,738 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Multiple myeloma OR: 1.327 [1.165, 1.511]
β: 0.283 (0.0663)
AUROC: 0.577 [0.537, 0.617] Nagelkerke's Pseudo-R²: 0.0145
Brier score: 0.0818
Odds Ratio (OR, top 1% vs. Rest): 2.2 [0.855, 5.66]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE204.4_GWAS-Catalog-r2019-05-03-X204.4_P_5e-08_UKB_20200608
PPM001337 PGS000652
(PRSWEB_PHECODE204.4_C90_PT_MGI_20200608)
PSS000563|
European Ancestry|
908 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Multiple myeloma OR: 1.24 [1.005, 1.529]
β: 0.215 (0.107)
AUROC: 0.547 [0.479, 0.613] Nagelkerke's Pseudo-R²: 0.00945
Brier score: 0.0823
Odds Ratio (OR, top 1% vs. Rest): 2.6 [0.593, 11.4]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE204.4_C90_PT_MGI_20200608

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000563 PheCode:204.4; ICD9CM:203.00, 203.01, 203.02, 203.80, 203.81, 203.82; ICD10CM:C88.2, C88.3, C88.9, C90.0, C90.00, C90.01, C90.02, C90.2, C90.20, C90.21, C90.22, C90.30, C90.31, C90.32
[
  • 83 cases
  • , 825 controls
]
European MGI
PSS000582 PheCode:204.4; ICD9:203, 203.0, 203.8; ICD10:C88.1, C88.3, C88.9, C90.0, C90.2
[
  • 248 cases
  • , 2,490 controls
]
European UKB