Trait: atrial flutter

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003911
Description A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) [NCIT: P378]
Trait category
Cardiovascular disease
Synonyms 9 synonyms
  • Atrial Flutters
  • Auricular Flutter
  • Auricular Flutters
  • Flutter, Atrial
  • Flutter, Auricular
  • Flutters, Atrial
  • Flutters, Auricular
  • atrial flutter
  • atrial flutter (disease)
Mapped terms 10 mapped terms
  • HP:0004749
  • ICD9:427.32
  • MESH:D001282
  • MONDO:0005310
  • MeSH:D001282
  • MedDRA:10003662
  • NCIT:C51224
  • NCIt:C51224
  • SCTID:5370000
  • SNOMEDCT:5370000

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001263
(GBE_HC440)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Atrial flutter atrial flutter 2,087
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001263/ScoringFiles/PGS001263.txt.gz
PGS001339
(GBE_HC964)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Atrial fibrillation and flutter (time-to-event) atrial fibrillation,
atrial flutter
2,142
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001339/ScoringFiles/PGS001339.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009185 PGS001339
(GBE_HC964)
PSS004750|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.76362 [0.75604, 0.7712] : 0.133
Incremental AUROC (full-covars): 0.02354
PGS R2 (no covariates): 0.0246
PGS AUROC (no covariates): 0.6108 [0.60113, 0.62048]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009184 PGS001339
(GBE_HC964)
PSS004749|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.73999 [0.70422, 0.77576] : 0.09669
Incremental AUROC (full-covars): -0.00357
PGS R2 (no covariates): 0.00629
PGS AUROC (no covariates): 0.56035 [0.51988, 0.60082]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009183 PGS001339
(GBE_HC964)
PSS004748|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.77656 [0.76352, 0.7896] : 0.14023
Incremental AUROC (full-covars): 0.02188
PGS R2 (no covariates): 0.02447
PGS AUROC (no covariates): 0.613 [0.59591, 0.6301]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009182 PGS001339
(GBE_HC964)
PSS004747|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.8247 [0.75141, 0.898] : 0.15451
Incremental AUROC (full-covars): 0.0187
PGS R2 (no covariates): 0.01158
PGS AUROC (no covariates): 0.59663 [0.46689, 0.72636]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009181 PGS001339
(GBE_HC964)
PSS004746|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.75135 [0.70951, 0.7932] : 0.09804
Incremental AUROC (full-covars): -0.00345
PGS R2 (no covariates): 0.00273
PGS AUROC (no covariates): 0.53955 [0.48964, 0.58946]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008824 PGS001263
(GBE_HC440)
PSS004505|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Atrial flutter AUROC: 0.76368 [0.75572, 0.77165] : 0.12819
Incremental AUROC (full-covars): 0.02207
PGS R2 (no covariates): 0.02215
PGS AUROC (no covariates): 0.60821 [0.59797, 0.61845]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008823 PGS001263
(GBE_HC440)
PSS004504|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Atrial flutter AUROC: 0.73743 [0.69955, 0.77531] : 0.09462
Incremental AUROC (full-covars): -0.00059
PGS R2 (no covariates): 0.00793
PGS AUROC (no covariates): 0.57035 [0.52788, 0.61283]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008822 PGS001263
(GBE_HC440)
PSS004503|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Atrial flutter AUROC: 0.78179 [0.76842, 0.79516] : 0.1422
Incremental AUROC (full-covars): 0.02171
PGS R2 (no covariates): 0.02517
PGS AUROC (no covariates): 0.61716 [0.59934, 0.63498]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008821 PGS001263
(GBE_HC440)
PSS004502|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Atrial flutter AUROC: 0.82631 [0.7516, 0.90103] : 0.15678
Incremental AUROC (full-covars): 0.02031
PGS R2 (no covariates): 0.01354
PGS AUROC (no covariates): 0.59968 [0.4662, 0.73316]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008820 PGS001263
(GBE_HC440)
PSS004501|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Atrial flutter AUROC: 0.76033 [0.71757, 0.80309] : 0.10534
Incremental AUROC (full-covars): 0.00055
PGS R2 (no covariates): 0.00351
PGS AUROC (no covariates): 0.54665 [0.4962, 0.5971]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004746
[
  • 136 cases
  • , 6,361 controls
]
African unspecified UKB
PSS004747
[
  • 24 cases
  • , 1,680 controls
]
East Asian UKB
PSS004748
[
  • 1,090 cases
  • , 23,815 controls
]
European non-white British ancestry UKB
PSS004749
[
  • 200 cases
  • , 7,631 controls
]
South Asian UKB
PSS004750
[
  • 3,483 cases
  • , 63,942 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004501
[
  • 128 cases
  • , 6,369 controls
]
African unspecified UKB
PSS004502
[
  • 24 cases
  • , 1,680 controls
]
East Asian UKB
PSS004503
[
  • 983 cases
  • , 23,922 controls
]
European non-white British ancestry UKB
PSS004504
[
  • 186 cases
  • , 7,645 controls
]
South Asian UKB
PSS004505
[
  • 3,114 cases
  • , 64,311 controls
]
European white British ancestry UKB Testing cohort (heldout set)