Trait: alcohol drinking

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004329
Description Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
Trait category
Biological process
Synonym alcohol consumption
Mapped terms 2 mapped terms
  • MeSH:D000428
  • NCIt:C16273

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001901
(portability-PLR_drink_alcohol)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Alcohol drinker status alcohol drinking 1,065
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001901/ScoringFiles/PGS001901.txt.gz
PGS002115
(portability-ldpred2_drink_alcohol)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Alcohol drinker status alcohol drinking 766,714
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002115/ScoringFiles/PGS002115.txt.gz
PGS002909
(ExPRSweb_Drinking_20117-2_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Drinking status alcohol drinking 396,976
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002909/ScoringFiles/PGS002909.txt.gz
PGS002910
(ExPRSweb_Drinking_20117-2_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Drinking status alcohol drinking 10,123
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002910/ScoringFiles/PGS002910.txt.gz
PGS002911
(ExPRSweb_Drinking_20117-2_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Drinking status alcohol drinking 20,050
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002911/ScoringFiles/PGS002911.txt.gz
PGS002912
(ExPRSweb_Drinking_20117-2_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Drinking status alcohol drinking 8,598,752
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002912/ScoringFiles/PGS002912.txt.gz
PGS002913
(ExPRSweb_Drinking_20117-2_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Drinking status alcohol drinking 1,113,832
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002913/ScoringFiles/PGS002913.txt.gz
PGS019953
(PRS10_AD)
 PGP000841 |
Park CS et al. Heart Rhythm (2024)
 Alcohol metabolism alcohol drinking 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019953/ScoringFiles/PGS019953.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010091 PGS001901
(portability-PLR_drink_alcohol)
 PSS009398|
European Ancestry|
19,294 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0209 [0.0068, 0.035] sex, age, birth date, deprivation index, 16 PCs —
PPM010092 PGS001901
(portability-PLR_drink_alcohol)
 PSS009172|
European Ancestry|
3,938 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0195 [-0.0118, 0.0508] sex, age, birth date, deprivation index, 16 PCs —
PPM010093 PGS001901
(portability-PLR_drink_alcohol)
 PSS008726|
European Ancestry|
6,413 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0217 [-0.0028, 0.0462] sex, age, birth date, deprivation index, 16 PCs —
PPM010094 PGS001901
(portability-PLR_drink_alcohol)
 PSS008500|
Greater Middle Eastern Ancestry|
1,101 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0069 [-0.0527, 0.0665] sex, age, birth date, deprivation index, 16 PCs —
PPM010095 PGS001901
(portability-PLR_drink_alcohol)
 PSS008278|
South Asian Ancestry|
5,830 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0024 [-0.0233, 0.0281] sex, age, birth date, deprivation index, 16 PCs —
PPM010096 PGS001901
(portability-PLR_drink_alcohol)
 PSS008055|
East Asian Ancestry|
1,726 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0204 [-0.0271, 0.0678] sex, age, birth date, deprivation index, 16 PCs —
PPM010097 PGS001901
(portability-PLR_drink_alcohol)
 PSS007842|
African Ancestry|
2,357 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0195 [-0.021, 0.06] sex, age, birth date, deprivation index, 16 PCs —
PPM010098 PGS001901
(portability-PLR_drink_alcohol)
 PSS008946|
African Ancestry|
3,609 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0279 [-0.0048, 0.0606] sex, age, birth date, deprivation index, 16 PCs —
PPM011775 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS009398|
European Ancestry|
19,294 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0284 [0.0143, 0.0425] sex, age, birth date, deprivation index, 16 PCs —
PPM011776 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS009172|
European Ancestry|
3,938 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0691 [0.0379, 0.1002] sex, age, birth date, deprivation index, 16 PCs —
PPM011777 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS008726|
European Ancestry|
6,413 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0566 [0.0321, 0.081] sex, age, birth date, deprivation index, 16 PCs —
PPM011778 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS008500|
Greater Middle Eastern Ancestry|
1,101 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0437 [-0.016, 0.1031] sex, age, birth date, deprivation index, 16 PCs —
PPM011779 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS008278|
South Asian Ancestry|
5,830 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0014 [-0.0243, 0.0271] sex, age, birth date, deprivation index, 16 PCs —
PPM011780 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS008055|
East Asian Ancestry|
1,726 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.02 [-0.0275, 0.0674] sex, age, birth date, deprivation index, 16 PCs —
PPM011781 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS007842|
African Ancestry|
2,357 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0094 [-0.0311, 0.0499] sex, age, birth date, deprivation index, 16 PCs —
PPM011782 PGS002115
(portability-ldpred2_drink_alcohol)
 PSS008946|
African Ancestry|
3,609 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Alcohol drinker status — — Partial Correlation (partial-r): 0.0434 [0.0107, 0.076] sex, age, birth date, deprivation index, 16 PCs —
PPM015788 PGS002909
(ExPRSweb_Drinking_20117-2_LASSOSUM_MGI_20211120)
 PSS010002|
European Ancestry|
22,425 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Drinking Status OR: 1.151 [1.118, 1.184]
β: 0.14 (0.0146)		 AUROC: 0.539 [0.531, 0.548] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015791 PGS002910
(ExPRSweb_Drinking_20117-2_PT_MGI_20211120)
 PSS010002|
European Ancestry|
22,425 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Drinking Status OR: 1.116 [1.085, 1.148]
β: 0.11 (0.0144)		 AUROC: 0.533 [0.525, 0.541] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015789 PGS002911
(ExPRSweb_Drinking_20117-2_PLINK_MGI_20211120)
 PSS010002|
European Ancestry|
22,425 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Drinking Status OR: 1.081 [1.05, 1.112]
β: 0.0776 (0.0145)		 AUROC: 0.521 [0.513, 0.529] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015787 PGS002912
(ExPRSweb_Drinking_20117-2_DBSLMM_MGI_20211120)
 PSS010002|
European Ancestry|
22,425 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Drinking Status OR: 1.038 [1.009, 1.068]
β: 0.037 (0.0145)		 AUROC: 0.52 [0.512, 0.528] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015790 PGS002913
(ExPRSweb_Drinking_20117-2_PRSCS_MGI_20211120)
 PSS010002|
European Ancestry|
22,425 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Drinking Status OR: 1.179 [1.145, 1.213]
β: 0.165 (0.0147)		 AUROC: 0.547 [0.539, 0.555] — SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM038139 PGS019953
(PRS10_AD)
 PSS013833|
European Ancestry|
397,164 individuals
 PGP000841 |
Park CS et al. Heart Rhythm (2024)
 Reported Trait: Alcohol consumption HR: 1.01 [0.98, 1.05] — — age, sex, hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, heart failure, valvular heat disease, peripheral artery disease, chronic kidney disease, liver disease, alcohol consumption habit —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008946 — — 3,609 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009172 — — 3,938 individuals — European Poland (NE Europe) UKB —
PSS008500 — — 1,101 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009398 — — 19,294 individuals — European UK (+ Ireland) UKB —
PSS008726 — — 6,413 individuals — European Italy (South Europe) UKB —
PSS008278 — — 5,830 individuals — South Asian India (South Asia) UKB —
PSS008055 — — 1,726 individuals — East Asian China (East Asia) UKB —
PSS010002 never/past/current alcohol use was recoded to never/ever responses.; Binary —
[
  • 15,343 cases
  • , 7,082 controls
]
 — European — MGI —
PSS013833 — — 397,164 individuals,
45.9 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European
(British)		 — UKB —
PSS007842 — — 2,357 individuals — African American or Afro-Caribbean Carribean UKB —