Trait: addictive behaviour

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004347
Description The observable, measurable, and often pathological activity of an organism that portrays its inability to overcome a habit resulting in an insatiable craving for a substance or for performing certain acts. The addictive behavior includes the emotional and physical overdependence on the object of habit in increasing amount or frequency.
Trait category
Biological process
Synonyms 2 synonyms
  • addictive behavior
  • behavior, addictive
Mapped terms 2 mapped terms
  • MeSH:D016739
  • MedDRA:10079410

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002124
(portability-ldpred2_ever_addicted)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Ever addicted to any substance or behaviour addictive behaviour 566,292
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002124/ScoringFiles/PGS002124.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011847 PGS002124
(portability-ldpred2_ever_addicted)
 PSS009401|
European Ancestry|
6,380 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.0328 [0.0082, 0.0573] sex, age, birth date, deprivation index, 16 PCs —
PPM011848 PGS002124
(portability-ldpred2_ever_addicted)
 PSS009175|
European Ancestry|
1,218 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.0465 [-0.0101, 0.1029] sex, age, birth date, deprivation index, 16 PCs —
PPM011849 PGS002124
(portability-ldpred2_ever_addicted)
 PSS008729|
European Ancestry|
2,243 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0196 [-0.0611, 0.022] sex, age, birth date, deprivation index, 16 PCs —
PPM011850 PGS002124
(portability-ldpred2_ever_addicted)
 PSS008503|
Greater Middle Eastern Ancestry|
203 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.1801 [0.036, 0.3169] sex, age, birth date, deprivation index, 16 PCs —
PPM011851 PGS002124
(portability-ldpred2_ever_addicted)
 PSS008281|
South Asian Ancestry|
811 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0084 [-0.0781, 0.0613] sex, age, birth date, deprivation index, 16 PCs —
PPM011852 PGS002124
(portability-ldpred2_ever_addicted)
 PSS008058|
East Asian Ancestry|
421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0768 [-0.1734, 0.0213] sex, age, birth date, deprivation index, 16 PCs —
PPM011853 PGS002124
(portability-ldpred2_ever_addicted)
 PSS007845|
African Ancestry|
371 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.0547 [-0.0503, 0.1585] sex, age, birth date, deprivation index, 16 PCs —
PPM011854 PGS002124
(portability-ldpred2_ever_addicted)
 PSS008949|
African Ancestry|
513 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0558 [-0.1434, 0.0326] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007845 — — 371 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008949 — — 513 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008503 — — 203 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009175 — — 1,218 individuals — European Poland (NE Europe) UKB —
PSS008729 — — 2,243 individuals — European Italy (South Europe) UKB —
PSS009401 — — 6,380 individuals — European UK (+ Ireland) UKB —
PSS008281 — — 811 individuals — South Asian India (South Asia) UKB —
PSS008058 — — 421 individuals — East Asian China (East Asia) UKB —