Trait: HOMA-B

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004469
Description The HOMA-B measurement employs the homeostatic model assessment (HOMA) to quantify beta-cell function.
Trait category
Other measurement
Synonym homeostasis model assessment B cell function

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003469
(LDPred2_HOMA_B)
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 HOMA-B HOMA-B 775,825
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003469/ScoringFiles/PGS003469.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017280 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index β: 0.002 (0.01) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017303 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea β: 0.023 (0.024) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017348 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in obsese β: 0.025 (0.017) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017368 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in obsese β: 0.049 (0.034) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017369 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in non-obsese β: -0.007 (0.035) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017396 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index x obesity interaction β: 0.041 (1.042) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017349 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in non-obsese β: -0.016 (0.012) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017406 PGS003469
(LDPred2_HOMA_B)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea x obesity interaction β: 1.041 (0.049) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS, SOL —