Trait: urate measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004531
Description A urate measurement is the quantification of some urate in body fluid
Trait category
Other measurement
Synonym urate levels
Mapped term NCIt:C64814

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000126
(Urate_GRS)
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Serum urate urate measurement 114
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000126/ScoringFiles/PGS000126.txt.gz
PGS000700
(snpnet.Urate)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Urate [umol/L] urate measurement 20,171
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000700/ScoringFiles/PGS000700.txt.gz - Check Terms/Licenses
PGS002010
(portability-PLR_urate)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Urate urate measurement 75,102
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002010/ScoringFiles/PGS002010.txt.gz
PGS002229
(portability-ldpred2_urate)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Urate urate measurement 698,001
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002229/ScoringFiles/PGS002229.txt.gz
PGS003572
(cont-decay-urate)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Urate urate measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003572/ScoringFiles/PGS003572.txt.gz
PGS003991
(dbslmm.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 1,005,456
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003991/ScoringFiles/PGS003991.txt.gz
PGS004007
(lassosum.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 19,101
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004007/ScoringFiles/PGS004007.txt.gz
PGS004019
(lassosum.CV.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 56,575
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004019/ScoringFiles/PGS004019.txt.gz
PGS004033
(ldpred2.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 865,644
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004033/ScoringFiles/PGS004033.txt.gz
PGS004048
(ldpred2.CV.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 865,644
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004048/ScoringFiles/PGS004048.txt.gz
PGS004061
(megaprs.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 677,631
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004061/ScoringFiles/PGS004061.txt.gz
PGS004077
(megaprs.CV.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 677,631
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004077/ScoringFiles/PGS004077.txt.gz
PGS004091
(prscs.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 976,777
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004091/ScoringFiles/PGS004091.txt.gz
PGS004115
(pt_clump.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 248
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004115/ScoringFiles/PGS004115.txt.gz
PGS004131
(pt_clump_nested.CV.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 7,279
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004131/ScoringFiles/PGS004131.txt.gz
PGS004145
(sbayesr.auto.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 822,407
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004145/ScoringFiles/PGS004145.txt.gz
PGS004161
(UKBB_EnsPGS.GCST008972.Urate)
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Urate urate measurement 1,005,478
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004161/ScoringFiles/PGS004161.txt.gz
PGS004343
(X30880.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Urate (umol/L) urate measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004343/ScoringFiles/PGS004343.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000406 PGS000126
(Urate_GRS)
 PSS000233|
European Ancestry|
334,880 individuals
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Reported Trait: Prevalent gout cases — AUROC: 0.84 — age, sex —
PPM000405 PGS000126
(Urate_GRS)
 PSS000233|
European Ancestry|
334,880 individuals
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Reported Trait: Prevalent gout cases — AUROC: 0.67 — — —
PPM012772 PGS000126
(Urate_GRS)
 PSS009550|
European Ancestry|
8,246 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 2.01 [1.69, 2.39] BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012773 PGS000126
(Urate_GRS)
 PSS009549|
European Ancestry|
10,888 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.41 [1.34, 1.48] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012774 PGS000126
(Urate_GRS)
 PSS009549|
European Ancestry|
10,888 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.97 BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012771 PGS000126
(Urate_GRS)
 PSS009550|
European Ancestry|
8,246 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.41 [1.19, 1.68] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM021126 PGS000126
(Urate_GRS)
 PSS011533|
European Ancestry|
43,991 individuals
 PGP000615 |
Zhang Y et al. Front Genet (2021)
|Ext.		 Reported Trait: Gout β: 1.495 [1.372, 1.619] — — Age, sex, body mass index, first 10 PCs Only 110 of 114 SNPs were used for score calculation due to poor imputation quality for 4 SNPs
PPM021127 PGS000126
(Urate_GRS)
 PSS011534|
European Ancestry|
12,164 individuals
 PGP000615 |
Zhang Y et al. Front Genet (2021)
|Ext.		 Reported Trait: Gout — AUROC: 0.804 — Age, sex, body mass index Only 110 of 114 SNPs were used for score calculation due to poor imputation quality for 4 SNPs
PPM001428 PGS000700
(snpnet.Urate)
 PSS000777|
African Ancestry|
6,011 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Urate [umol/L] — — R²: 0.29536
Spearman's ρ: 0.24		 Age, sex, PCs(1-40) —
PPM001463 PGS000700
(snpnet.Urate)
 PSS000778|
East Asian Ancestry|
1,080 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Urate [umol/L] — — R²: 0.33805
Spearman's ρ: 0.269		 Age, sex, PCs(1-40) —
PPM001498 PGS000700
(snpnet.Urate)
 PSS000779|
European Ancestry|
23,561 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Urate [umol/L] — — R²: 0.42054
Spearman's ρ: 0.361		 Age, sex, PCs(1-40) —
PPM001533 PGS000700
(snpnet.Urate)
 PSS000780|
South Asian Ancestry|
7,328 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Urate [umol/L] — — R²: 0.32468
Spearman's ρ: 0.308		 Age, sex, PCs(1-40) —
PPM001568 PGS000700
(snpnet.Urate)
 PSS000781|
European Ancestry|
63,704 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Urate [umol/L] — — R²: 0.3966
Spearman's ρ: 0.378		 Age, sex, PCs(1-40) —
PPM007425 PGS000700
(snpnet.Urate)
 PSS007211|
African Ancestry|
6,093 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Urate — — R²: 0.23316 [0.21516, 0.25115]
Incremental R2 (full-covars): 0.00036
PGS R2 (no covariates): 0.04257 [0.03297, 0.05217]		 age, sex, UKB array type, Genotype PCs —
PPM007426 PGS000700
(snpnet.Urate)
 PSS007212|
East Asian Ancestry|
1,614 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Urate — — R²: 0.28286 [0.24672, 0.31901]
Incremental R2 (full-covars): 0.00043
PGS R2 (no covariates): 0.05737 [0.03597, 0.07876]		 age, sex, UKB array type, Genotype PCs —
PPM007427 PGS000700
(snpnet.Urate)
 PSS007213|
European Ancestry|
23,752 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Urate — — R²: 0.31443 [0.30488, 0.32398]
Incremental R2 (full-covars): 0.00063
PGS R2 (no covariates): 0.0839 [0.07731, 0.09049]		 age, sex, UKB array type, Genotype PCs —
PPM007428 PGS000700
(snpnet.Urate)
 PSS007214|
South Asian Ancestry|
7,418 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Urate — — R²: 0.22062 [0.20441, 0.23683]
Incremental R2 (full-covars): 0.00055
PGS R2 (no covariates): 0.07337 [0.06226, 0.08448]		 age, sex, UKB array type, Genotype PCs —
PPM007429 PGS000700
(snpnet.Urate)
 PSS007215|
European Ancestry|
64,383 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Urate — — R²: 0.27496 [0.26922, 0.2807]
Incremental R2 (full-covars): 0.00069
PGS R2 (no covariates): 0.10013 [0.09583, 0.10442]		 age, sex, UKB array type, Genotype PCs —
PPM010954 PGS002010
(portability-PLR_urate)
 PSS009495|
European Ancestry|
18,977 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3885 [0.3763, 0.4005] sex, age, birth date, deprivation index, 16 PCs —
PPM010955 PGS002010
(portability-PLR_urate)
 PSS009269|
European Ancestry|
3,948 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3794 [0.3523, 0.4058] sex, age, birth date, deprivation index, 16 PCs —
PPM010956 PGS002010
(portability-PLR_urate)
 PSS008823|
European Ancestry|
6,318 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3878 [0.3666, 0.4086] sex, age, birth date, deprivation index, 16 PCs —
PPM010957 PGS002010
(portability-PLR_urate)
 PSS008597|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3602 [0.3077, 0.4104] sex, age, birth date, deprivation index, 16 PCs —
PPM010958 PGS002010
(portability-PLR_urate)
 PSS008375|
South Asian Ancestry|
5,991 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3429 [0.3203, 0.3651] sex, age, birth date, deprivation index, 16 PCs —
PPM010959 PGS002010
(portability-PLR_urate)
 PSS008151|
East Asian Ancestry|
1,714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3222 [0.2788, 0.3642] sex, age, birth date, deprivation index, 16 PCs —
PPM010960 PGS002010
(portability-PLR_urate)
 PSS007939|
African Ancestry|
2,343 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.2409 [0.2022, 0.2789] sex, age, birth date, deprivation index, 16 PCs —
PPM010961 PGS002010
(portability-PLR_urate)
 PSS009043|
African Ancestry|
3,652 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.2438 [0.2129, 0.2741] sex, age, birth date, deprivation index, 16 PCs —
PPM012683 PGS002229
(portability-ldpred2_urate)
 PSS008151|
East Asian Ancestry|
1,714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3108 [0.2672, 0.3532] sex, age, birth date, deprivation index, 16 PCs —
PPM012678 PGS002229
(portability-ldpred2_urate)
 PSS009495|
European Ancestry|
18,977 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3761 [0.3638, 0.3882] sex, age, birth date, deprivation index, 16 PCs —
PPM012679 PGS002229
(portability-ldpred2_urate)
 PSS009269|
European Ancestry|
3,948 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3765 [0.3494, 0.4031] sex, age, birth date, deprivation index, 16 PCs —
PPM012680 PGS002229
(portability-ldpred2_urate)
 PSS008823|
European Ancestry|
6,318 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3837 [0.3624, 0.4045] sex, age, birth date, deprivation index, 16 PCs —
PPM012681 PGS002229
(portability-ldpred2_urate)
 PSS008597|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3571 [0.3046, 0.4075] sex, age, birth date, deprivation index, 16 PCs —
PPM012682 PGS002229
(portability-ldpred2_urate)
 PSS008375|
South Asian Ancestry|
5,991 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.3348 [0.3121, 0.3571] sex, age, birth date, deprivation index, 16 PCs —
PPM012685 PGS002229
(portability-ldpred2_urate)
 PSS009043|
African Ancestry|
3,652 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.2404 [0.2096, 0.2708] sex, age, birth date, deprivation index, 16 PCs —
PPM012684 PGS002229
(portability-ldpred2_urate)
 PSS007939|
African Ancestry|
2,343 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urate — — Partial Correlation (partial-r): 0.2311 [0.1923, 0.2693] sex, age, birth date, deprivation index, 16 PCs —
PPM017836 PGS003572
(cont-decay-urate)
 PSS010268|
European Ancestry|
2,232 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017500 PGS003572
(cont-decay-urate)
 PSS010940|
European Ancestry|
19,082 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017584 PGS003572
(cont-decay-urate)
 PSS010856|
European Ancestry|
3,937 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.14 sex, age, deprivation index, PC1-16 —
PPM017668 PGS003572
(cont-decay-urate)
 PSS010688|
European Ancestry|
6,166 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017752 PGS003572
(cont-decay-urate)
 PSS010604|
Greater Middle Eastern Ancestry|
1,095 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.14 sex, age, deprivation index, PC1-16 —
PPM017920 PGS003572
(cont-decay-urate)
 PSS010520|
South Asian Ancestry|
5,937 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.11 sex, age, deprivation index, PC1-16 —
PPM018004 PGS003572
(cont-decay-urate)
 PSS010436|
East Asian Ancestry|
1,703 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM018088 PGS003572
(cont-decay-urate)
 PSS010352|
African Ancestry|
2,331 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM018172 PGS003572
(cont-decay-urate)
 PSS010772|
African Ancestry|
3,623 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urate — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM019840 PGS003991
(dbslmm.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.20962 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019843 PGS003991
(dbslmm.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.21712 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019845 PGS003991
(dbslmm.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.25263 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019903 PGS004007
(lassosum.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.23632 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019906 PGS004007
(lassosum.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.22465 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019908 PGS004007
(lassosum.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.26029 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019916 PGS004019
(lassosum.CV.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.26269 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019917 PGS004019
(lassosum.CV.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.24751 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019918 PGS004019
(lassosum.CV.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.27253 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019867 PGS004033
(ldpred2.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.18346 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019870 PGS004033
(ldpred2.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.19643 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019872 PGS004033
(ldpred2.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.27115 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019813 PGS004048
(ldpred2.CV.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.25902 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019816 PGS004048
(ldpred2.CV.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.25163 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019818 PGS004048
(ldpred2.CV.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.28769 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019882 PGS004061
(megaprs.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.24798 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019885 PGS004061
(megaprs.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.24495 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019887 PGS004061
(megaprs.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.26687 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019889 PGS004077
(megaprs.CV.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.24953 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019890 PGS004077
(megaprs.CV.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.25448 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019891 PGS004077
(megaprs.CV.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.27905 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019894 PGS004091
(prscs.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.21095 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019899 PGS004091
(prscs.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.27156 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019897 PGS004091
(prscs.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.20722 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019822 PGS004115
(pt_clump.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.20755 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019825 PGS004115
(pt_clump.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.19593 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019827 PGS004115
(pt_clump.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.19725 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019831 PGS004131
(pt_clump_nested.CV.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.21235 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019834 PGS004131
(pt_clump_nested.CV.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.20496 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019836 PGS004131
(pt_clump_nested.CV.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.22201 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019849 PGS004145
(sbayesr.auto.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.12294 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019852 PGS004145
(sbayesr.auto.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.13599 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019854 PGS004145
(sbayesr.auto.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.2343 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019856 PGS004161
(UKBB_EnsPGS.GCST008972.Urate)
 PSS011250|
European Ancestry|
4,730 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.2779 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019857 PGS004161
(UKBB_EnsPGS.GCST008972.Urate)
 PSS011292|
South Asian Ancestry|
8,842 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.26797 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM019858 PGS004161
(UKBB_EnsPGS.GCST008972.Urate)
 PSS011279|
European Ancestry|
85,973 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Urate β: 0.30227 — — 0 beta = sd_trait/sd_pgs = pearson correlation
PPM020458 PGS004343
(X30880.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Urate (umol/L) — — PGS R2 (no covariates): 0.26795 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011279 — — 85,973 individuals — European — UKB —
PSS009043 — — 3,652 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008151 — — 1,714 individuals — East Asian China (East Asia) UKB —
PSS011292 — — 8,842 individuals — South Asian — UKB —
PSS011533 Cases are individuals with gout (phecode: 274.10) —
[
  • 2,858 cases
  • , 41,133 controls
]
 — European — MyCode Possible partial sample overlap between this dataset and the MyCode cohort used to source the score
PSS011534 Cases are individuals with gout —
[
  • 561 cases
  • , 11,603 controls
]
 — European — MyCode —
PSS010940 — — 19,082 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010688 — — 6,166 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS010436 — — 1,703 individuals,
33.0 % Male samples
 Mean = 52.4 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS009549 — —
[
  • 1,703 cases
  • , 9,185 controls
]
,
100.0 % Male samples
 — European — HPFS —
PSS009550 — —
[
  • 188 cases
  • , 8,058 controls
]
,
0.0 % Male samples
 — European — NHS2 —
PSS008823 — — 6,318 individuals — European Italy (South Europe) UKB —
PSS007939 — — 2,343 individuals — African American or Afro-Caribbean Carribean UKB —
PSS010856 — — 3,937 individuals,
38.0 % Male samples
 Mean = 54.4 years
Sd = 7.5 years		 European Polish UKB —
PSS010604 — — 1,095 individuals,
60.0 % Male samples
 Mean = 51.9 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS008597 — — 1,124 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS000233 Gout identified by self-report at the inclusion visit, individuals with an ICD-10 for gout (M10) in hospital admissions who did not self-report gout were excluded from the analysis. —
[
  • 4,908 cases
  • , 329,972 controls
]
 — European White British subset, unrelated UKB —
PSS009495 — — 18,977 individuals — European UK (+ Ireland) UKB —
PSS010352 — — 2,331 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS000777 — — 6,011 individuals — African unspecified — UKB —
PSS000778 — — 1,080 individuals — East Asian — UKB —
PSS000779 — — 23,561 individuals — European Non-British White UKB —
PSS000780 — — 7,328 individuals — South Asian — UKB —
PSS000781 — — 63,704 individuals — European
(British)		 — UKB —
PSS011250 — — 4,730 individuals — European — G&H —
PSS007211 — — 6,093 individuals — African unspecified — UKB —
PSS007212 — — 1,614 individuals — East Asian — UKB —
PSS007213 — — 23,752 individuals — European non-white British ancestry UKB —
PSS007214 — — 7,418 individuals — South Asian — UKB —
PSS007215 — — 64,383 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009269 — — 3,948 individuals — European Poland (NE Europe) UKB —
PSS008375 — — 5,991 individuals — South Asian India (South Asia) UKB —
PSS010772 — — 3,623 individuals,
46.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010520 — — 5,937 individuals,
54.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010268 — — 2,232 individuals,
45.0 % Male samples
 Mean = 58.1 years
Sd = 7.1 years		 European Ashkenazi UKB —