Trait: urate measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004531
Description A urate measurement is the quantification of some urate in body fluid
Trait category
Other measurement
Synonym urate levels
Mapped term NCIt:C64814

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000126
(Urate_GRS)
PGP000063 |
Tin A et al. Nat Genet (2019)
Serum urate urate measurement 114
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000126/ScoringFiles/PGS000126.txt.gz
PGS000700
(snpnet.Urate)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Urate [umol/L] urate measurement 20,171
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000700/ScoringFiles/PGS000700.txt.gz - Check Terms/Licenses
PGS002010
(portability-PLR_urate)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Urate urate measurement 75,102
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002010/ScoringFiles/PGS002010.txt.gz
PGS002229
(portability-ldpred2_urate)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Urate urate measurement 698,001
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002229/ScoringFiles/PGS002229.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000406 PGS000126
(Urate_GRS)
PSS000233|
European Ancestry|
334,880 individuals
PGP000063 |
Tin A et al. Nat Genet (2019)
Reported Trait: Prevalent gout cases AUROC: 0.84 age, sex
PPM000405 PGS000126
(Urate_GRS)
PSS000233|
European Ancestry|
334,880 individuals
PGP000063 |
Tin A et al. Nat Genet (2019)
Reported Trait: Prevalent gout cases AUROC: 0.67
PPM012772 PGS000126
(Urate_GRS)
PSS009550|
European Ancestry|
8,246 individuals
PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.
Reported Trait: Incident gout Relative Risk (RR): 2.01 [1.69, 2.39] BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only).
PPM012773 PGS000126
(Urate_GRS)
PSS009549|
European Ancestry|
10,888 individuals
PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.
Reported Trait: Incident gout Relative Risk (RR): 1.41 [1.34, 1.48] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only).
PPM012774 PGS000126
(Urate_GRS)
PSS009549|
European Ancestry|
10,888 individuals
PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.
Reported Trait: Incident gout Relative Risk (RR): 1.97 BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only).
PPM012771 PGS000126
(Urate_GRS)
PSS009550|
European Ancestry|
8,246 individuals
PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.
Reported Trait: Incident gout Relative Risk (RR): 1.41 [1.19, 1.68] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only).
PPM001428 PGS000700
(snpnet.Urate)
PSS000777|
African Ancestry|
6,011 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Urate [umol/L] : 0.29536
Spearman's ρ: 0.24
Age, sex, PCs(1-40)
PPM001463 PGS000700
(snpnet.Urate)
PSS000778|
East Asian Ancestry|
1,080 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Urate [umol/L] : 0.33805
Spearman's ρ: 0.269
Age, sex, PCs(1-40)
PPM001498 PGS000700
(snpnet.Urate)
PSS000779|
European Ancestry|
23,561 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Urate [umol/L] : 0.42054
Spearman's ρ: 0.361
Age, sex, PCs(1-40)
PPM001533 PGS000700
(snpnet.Urate)
PSS000780|
South Asian Ancestry|
7,328 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Urate [umol/L] : 0.32468
Spearman's ρ: 0.308
Age, sex, PCs(1-40)
PPM001568 PGS000700
(snpnet.Urate)
PSS000781|
European Ancestry|
63,704 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Urate [umol/L] : 0.3966
Spearman's ρ: 0.378
Age, sex, PCs(1-40)
PPM007425 PGS000700
(snpnet.Urate)
PSS007211|
African Ancestry|
6,093 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Urate : 0.23316 [0.21516, 0.25115]
Incremental R2 (full-covars): 0.00036
PGS R2 (no covariates): 0.04257 [0.03297, 0.05217]
age, sex, UKB array type, Genotype PCs
PPM007426 PGS000700
(snpnet.Urate)
PSS007212|
East Asian Ancestry|
1,614 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Urate : 0.28286 [0.24672, 0.31901]
Incremental R2 (full-covars): 0.00043
PGS R2 (no covariates): 0.05737 [0.03597, 0.07876]
age, sex, UKB array type, Genotype PCs
PPM007427 PGS000700
(snpnet.Urate)
PSS007213|
European Ancestry|
23,752 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Urate : 0.31443 [0.30488, 0.32398]
Incremental R2 (full-covars): 0.00063
PGS R2 (no covariates): 0.0839 [0.07731, 0.09049]
age, sex, UKB array type, Genotype PCs
PPM007428 PGS000700
(snpnet.Urate)
PSS007214|
South Asian Ancestry|
7,418 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Urate : 0.22062 [0.20441, 0.23683]
Incremental R2 (full-covars): 0.00055
PGS R2 (no covariates): 0.07337 [0.06226, 0.08448]
age, sex, UKB array type, Genotype PCs
PPM007429 PGS000700
(snpnet.Urate)
PSS007215|
European Ancestry|
64,383 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Urate : 0.27496 [0.26922, 0.2807]
Incremental R2 (full-covars): 0.00069
PGS R2 (no covariates): 0.10013 [0.09583, 0.10442]
age, sex, UKB array type, Genotype PCs
PPM010954 PGS002010
(portability-PLR_urate)
PSS009495|
European Ancestry|
18,977 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3885 [0.3763, 0.4005] sex, age, birth date, deprivation index, 16 PCs
PPM010955 PGS002010
(portability-PLR_urate)
PSS009269|
European Ancestry|
3,948 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3794 [0.3523, 0.4058] sex, age, birth date, deprivation index, 16 PCs
PPM010956 PGS002010
(portability-PLR_urate)
PSS008823|
European Ancestry|
6,318 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3878 [0.3666, 0.4086] sex, age, birth date, deprivation index, 16 PCs
PPM010957 PGS002010
(portability-PLR_urate)
PSS008597|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3602 [0.3077, 0.4104] sex, age, birth date, deprivation index, 16 PCs
PPM010958 PGS002010
(portability-PLR_urate)
PSS008375|
South Asian Ancestry|
5,991 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3429 [0.3203, 0.3651] sex, age, birth date, deprivation index, 16 PCs
PPM010959 PGS002010
(portability-PLR_urate)
PSS008151|
East Asian Ancestry|
1,714 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3222 [0.2788, 0.3642] sex, age, birth date, deprivation index, 16 PCs
PPM010960 PGS002010
(portability-PLR_urate)
PSS007939|
African Ancestry|
2,343 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.2409 [0.2022, 0.2789] sex, age, birth date, deprivation index, 16 PCs
PPM010961 PGS002010
(portability-PLR_urate)
PSS009043|
African Ancestry|
3,652 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.2438 [0.2129, 0.2741] sex, age, birth date, deprivation index, 16 PCs
PPM012683 PGS002229
(portability-ldpred2_urate)
PSS008151|
East Asian Ancestry|
1,714 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3108 [0.2672, 0.3532] sex, age, birth date, deprivation index, 16 PCs
PPM012678 PGS002229
(portability-ldpred2_urate)
PSS009495|
European Ancestry|
18,977 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3761 [0.3638, 0.3882] sex, age, birth date, deprivation index, 16 PCs
PPM012679 PGS002229
(portability-ldpred2_urate)
PSS009269|
European Ancestry|
3,948 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3765 [0.3494, 0.4031] sex, age, birth date, deprivation index, 16 PCs
PPM012680 PGS002229
(portability-ldpred2_urate)
PSS008823|
European Ancestry|
6,318 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3837 [0.3624, 0.4045] sex, age, birth date, deprivation index, 16 PCs
PPM012681 PGS002229
(portability-ldpred2_urate)
PSS008597|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3571 [0.3046, 0.4075] sex, age, birth date, deprivation index, 16 PCs
PPM012682 PGS002229
(portability-ldpred2_urate)
PSS008375|
South Asian Ancestry|
5,991 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.3348 [0.3121, 0.3571] sex, age, birth date, deprivation index, 16 PCs
PPM012685 PGS002229
(portability-ldpred2_urate)
PSS009043|
African Ancestry|
3,652 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.2404 [0.2096, 0.2708] sex, age, birth date, deprivation index, 16 PCs
PPM012684 PGS002229
(portability-ldpred2_urate)
PSS007939|
African Ancestry|
2,343 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Urate Partial Correlation (partial-r): 0.2311 [0.1923, 0.2693] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009043 3,652 individuals African unspecified Nigeria (West Africa) UKB
PSS008151 1,714 individuals East Asian China (East Asia) UKB
PSS009549
[
  • 1,703 cases
  • , 9,185 controls
]
,
100.0 % Male samples
European HPFS
PSS009550
[
  • 188 cases
  • , 8,058 controls
]
,
0.0 % Male samples
European NHS2
PSS008823 6,318 individuals European Italy (South Europe) UKB
PSS007939 2,343 individuals African American or Afro-Caribbean Carribean UKB
PSS000233 Gout identified by self-report at the inclusion visit, individuals with an ICD-10 for gout (M10) in hospital admissions who did not self-report gout were excluded from the analysis.
[
  • 4,908 cases
  • , 329,972 controls
]
European White British subset, unrelated UKB
PSS008597 1,124 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009495 18,977 individuals European UK (+ Ireland) UKB
PSS000777 6,011 individuals African unspecified UKB
PSS000778 1,080 individuals East Asian UKB
PSS000779 23,561 individuals European Non-British White UKB
PSS000780 7,328 individuals South Asian UKB
PSS000781 63,704 individuals European
(British)
UKB
PSS007211 6,093 individuals African unspecified UKB
PSS007212 1,614 individuals East Asian UKB
PSS007213 23,752 individuals European non-white British ancestry UKB
PSS007214 7,418 individuals South Asian UKB
PSS007215 64,383 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009269 3,948 individuals European Poland (NE Europe) UKB
PSS008375 5,991 individuals South Asian India (South Asia) UKB