Trait: bilirubin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004570
Description
  • A bilirubin measurement is a quantification of bilirubin typically measured in serum.
Trait category
Other measurement
Synonyms bilirubin levels
Mapped term(s) SNOMEDCT:302787001

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000681
(snpnet.Direct_bilirubin)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Direct bilirubin [umol/L] bilirubin measurement 3,104
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000681/ScoringFiles/PGS000681.txt.gz - Check Terms/Licenses
PGS000697
(snpnet.Total_bilirubin)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Total bilirubin [umol/L] bilirubin measurement 1,159
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000697/ScoringFiles/PGS000697.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001409 PGS000681
(snpnet.Direct_bilirubin)
PSS000684|
African Ancestry|
5,007 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.27938
Spearman's ρ: 0.469
Age, sex, PCs(1-40)
PPM001444 PGS000681
(snpnet.Direct_bilirubin)
PSS000685|
East Asian Ancestry|
915 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.15786
Spearman's ρ: 0.291
Age, sex, PCs(1-40)
PPM001479 PGS000681
(snpnet.Direct_bilirubin)
PSS000686|
European Ancestry|
20,094 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.33072
Spearman's ρ: 0.453
Age, sex, PCs(1-40)
PPM001514 PGS000681
(snpnet.Direct_bilirubin)
PSS000687|
South Asian Ancestry|
6,088 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.3015
Spearman's ρ: 0.452
Age, sex, PCs(1-40)
PPM001549 PGS000681
(snpnet.Direct_bilirubin)
PSS000688|
European Ancestry|
54,161 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.34294
Spearman's ρ: 0.46
Age, sex, PCs(1-40)
PPM001460 PGS000697
(snpnet.Total_bilirubin)
PSS000763|
East Asian Ancestry|
1,069 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.2156
Spearman's ρ: 0.347
Age, sex, PCs(1-40)
PPM001495 PGS000697
(snpnet.Total_bilirubin)
PSS000764|
European Ancestry|
23,472 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.42641
Spearman's ρ: 0.523
Age, sex, PCs(1-40)
PPM001530 PGS000697
(snpnet.Total_bilirubin)
PSS000765|
South Asian Ancestry|
7,313 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.43693
Spearman's ρ: 0.548
Age, sex, PCs(1-40)
PPM001565 PGS000697
(snpnet.Total_bilirubin)
PSS000766|
European Ancestry|
63,531 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.44377
Spearman's ρ: 0.533
Age, sex, PCs(1-40)
PPM001425 PGS000697
(snpnet.Total_bilirubin)
PSS000762|
African Ancestry|
5,978 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.38749
Spearman's ρ: 0.551
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000684 5,007 individuals African unspecified UKB
PSS000685 915 individuals East Asian UKB
PSS000686 20,094 individuals European Non-British White UKB
PSS000687 6,088 individuals South Asian UKB
PSS000688 54,161 individuals European
(British)
UKB
PSS000762 5,978 individuals African unspecified UKB
PSS000763 1,069 individuals East Asian UKB
PSS000764 23,472 individuals European Non-British White UKB
PSS000765 7,313 individuals South Asian UKB
PSS000766 63,531 individuals European
(British)
UKB