Trait: bilirubin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004570
Description A bilirubin measurement is a quantification of bilirubin typically measured in serum.
Trait category
Other measurement
Synonym bilirubin levels
Mapped term SNOMEDCT:302787001

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000681
(snpnet.Direct_bilirubin)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Direct bilirubin [umol/L] bilirubin measurement 3,104
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000681/ScoringFiles/PGS000681.txt.gz - Check Terms/Licenses
PGS000697
(snpnet.Total_bilirubin)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Total bilirubin [umol/L] bilirubin measurement 1,159
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000697/ScoringFiles/PGS000697.txt.gz - Check Terms/Licenses
PGS001942
(portability-PLR_log_bilirubin)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Total bilirubin bilirubin measurement 33,190
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001942/ScoringFiles/PGS001942.txt.gz
PGS002160
(portability-ldpred2_log_bilirubin)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Total bilirubin bilirubin measurement 120,068
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002160/ScoringFiles/PGS002160.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001409 PGS000681
(snpnet.Direct_bilirubin)
PSS000684|
African Ancestry|
5,007 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.27938
Spearman's ρ: 0.469
Age, sex, PCs(1-40)
PPM001444 PGS000681
(snpnet.Direct_bilirubin)
PSS000685|
East Asian Ancestry|
915 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.15786
Spearman's ρ: 0.291
Age, sex, PCs(1-40)
PPM001479 PGS000681
(snpnet.Direct_bilirubin)
PSS000686|
European Ancestry|
20,094 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.33072
Spearman's ρ: 0.453
Age, sex, PCs(1-40)
PPM001514 PGS000681
(snpnet.Direct_bilirubin)
PSS000687|
South Asian Ancestry|
6,088 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.3015
Spearman's ρ: 0.452
Age, sex, PCs(1-40)
PPM001549 PGS000681
(snpnet.Direct_bilirubin)
PSS000688|
European Ancestry|
54,161 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Direct bilirubin [umol/L] : 0.34294
Spearman's ρ: 0.46
Age, sex, PCs(1-40)
PPM007330 PGS000681
(snpnet.Direct_bilirubin)
PSS007111|
African Ancestry|
5,082 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Direct bilirubin : 0.17479 [0.15802, 0.19156]
Incremental R2 (full-covars): 0.12988
PGS R2 (no covariates): 0.1566 [0.14037, 0.17282]
age, sex, UKB array type, Genotype PCs
PPM007331 PGS000681
(snpnet.Direct_bilirubin)
PSS007112|
East Asian Ancestry|
1,363 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Direct bilirubin : 0.10285 [0.07558, 0.13012]
Incremental R2 (full-covars): 0.07269
PGS R2 (no covariates): 0.08571 [0.06034, 0.11108]
age, sex, UKB array type, Genotype PCs
PPM007332 PGS000681
(snpnet.Direct_bilirubin)
PSS007113|
European Ancestry|
20,309 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Direct bilirubin : 0.24142 [0.23216, 0.25068]
Incremental R2 (full-covars): 0.19386
PGS R2 (no covariates): 0.21889 [0.20981, 0.22797]
age, sex, UKB array type, Genotype PCs
PPM007333 PGS000681
(snpnet.Direct_bilirubin)
PSS007114|
South Asian Ancestry|
6,150 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Direct bilirubin : 0.19064 [0.17499, 0.20629]
Incremental R2 (full-covars): 0.13188
PGS R2 (no covariates): 0.13972 [0.12549, 0.15396]
age, sex, UKB array type, Genotype PCs
PPM007334 PGS000681
(snpnet.Direct_bilirubin)
PSS007115|
European Ancestry|
54,944 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Direct bilirubin : 0.23821 [0.23259, 0.24382]
Incremental R2 (full-covars): 0.18741
PGS R2 (no covariates): 0.20562 [0.20019, 0.21106]
age, sex, UKB array type, Genotype PCs
PPM001460 PGS000697
(snpnet.Total_bilirubin)
PSS000763|
East Asian Ancestry|
1,069 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.2156
Spearman's ρ: 0.347
Age, sex, PCs(1-40)
PPM001495 PGS000697
(snpnet.Total_bilirubin)
PSS000764|
European Ancestry|
23,472 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.42641
Spearman's ρ: 0.523
Age, sex, PCs(1-40)
PPM001530 PGS000697
(snpnet.Total_bilirubin)
PSS000765|
South Asian Ancestry|
7,313 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.43693
Spearman's ρ: 0.548
Age, sex, PCs(1-40)
PPM001565 PGS000697
(snpnet.Total_bilirubin)
PSS000766|
European Ancestry|
63,531 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.44377
Spearman's ρ: 0.533
Age, sex, PCs(1-40)
PPM001425 PGS000697
(snpnet.Total_bilirubin)
PSS000762|
African Ancestry|
5,978 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total bilirubin [umol/L] : 0.38749
Spearman's ρ: 0.551
Age, sex, PCs(1-40)
PPM007410 PGS000697
(snpnet.Total_bilirubin)
PSS007191|
African Ancestry|
6,059 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Total bilirubin : 0.10271 [0.08873, 0.11668]
Incremental R2 (full-covars): 0.03802
PGS R2 (no covariates): 0.21776 [0.20001, 0.2355]
age, sex, UKB array type, Genotype PCs
PPM007411 PGS000697
(snpnet.Total_bilirubin)
PSS007192|
East Asian Ancestry|
1,603 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Total bilirubin : 0.09391 [0.0676, 0.12023]
Incremental R2 (full-covars): 0.03098
PGS R2 (no covariates): 0.16038 [0.12851, 0.19224]
age, sex, UKB array type, Genotype PCs
PPM007412 PGS000697
(snpnet.Total_bilirubin)
PSS007193|
European Ancestry|
23,663 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Total bilirubin : 0.12047 [0.11289, 0.12805]
Incremental R2 (full-covars): 0.06093
PGS R2 (no covariates): 0.30905 [0.29951, 0.31859]
age, sex, UKB array type, Genotype PCs
PPM007413 PGS000697
(snpnet.Total_bilirubin)
PSS007194|
South Asian Ancestry|
7,401 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Total bilirubin : 0.14178 [0.12747, 0.15608]
Incremental R2 (full-covars): 0.05146
PGS R2 (no covariates): 0.25946 [0.24276, 0.27617]
age, sex, UKB array type, Genotype PCs
PPM007414 PGS000697
(snpnet.Total_bilirubin)
PSS007195|
European Ancestry|
64,211 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Total bilirubin : 0.12453 [0.11987, 0.1292]
Incremental R2 (full-covars): 0.06102
PGS R2 (no covariates): 0.30884 [0.30304, 0.31464]
age, sex, UKB array type, Genotype PCs
PPM010411 PGS001942
(portability-PLR_log_bilirubin)
PSS009438|
European Ancestry|
18,919 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.6051 [0.596, 0.6141] sex, age, birth date, deprivation index, 16 PCs
PPM010412 PGS001942
(portability-PLR_log_bilirubin)
PSS009212|
European Ancestry|
3,930 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.6191 [0.5993, 0.638] sex, age, birth date, deprivation index, 16 PCs
PPM010413 PGS001942
(portability-PLR_log_bilirubin)
PSS008766|
European Ancestry|
6,303 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.6087 [0.5929, 0.624] sex, age, birth date, deprivation index, 16 PCs
PPM010414 PGS001942
(portability-PLR_log_bilirubin)
PSS008540|
Greater Middle Eastern Ancestry|
1,120 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5648 [0.5231, 0.6037] sex, age, birth date, deprivation index, 16 PCs
PPM010415 PGS001942
(portability-PLR_log_bilirubin)
PSS008318|
South Asian Ancestry|
5,983 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5812 [0.5641, 0.5977] sex, age, birth date, deprivation index, 16 PCs
PPM010416 PGS001942
(portability-PLR_log_bilirubin)
PSS008095|
East Asian Ancestry|
1,702 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.4145 [0.3742, 0.4534] sex, age, birth date, deprivation index, 16 PCs
PPM010417 PGS001942
(portability-PLR_log_bilirubin)
PSS007882|
African Ancestry|
2,326 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5368 [0.5071, 0.5653] sex, age, birth date, deprivation index, 16 PCs
PPM010418 PGS001942
(portability-PLR_log_bilirubin)
PSS008986|
African Ancestry|
3,640 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5462 [0.5229, 0.5686] sex, age, birth date, deprivation index, 16 PCs
PPM012127 PGS002160
(portability-ldpred2_log_bilirubin)
PSS009438|
European Ancestry|
18,919 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5956 [0.5864, 0.6048] sex, age, birth date, deprivation index, 16 PCs
PPM012128 PGS002160
(portability-ldpred2_log_bilirubin)
PSS009212|
European Ancestry|
3,930 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.61 [0.5899, 0.6293] sex, age, birth date, deprivation index, 16 PCs
PPM012129 PGS002160
(portability-ldpred2_log_bilirubin)
PSS008766|
European Ancestry|
6,303 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5997 [0.5836, 0.6153] sex, age, birth date, deprivation index, 16 PCs
PPM012130 PGS002160
(portability-ldpred2_log_bilirubin)
PSS008540|
Greater Middle Eastern Ancestry|
1,120 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5608 [0.5189, 0.6] sex, age, birth date, deprivation index, 16 PCs
PPM012131 PGS002160
(portability-ldpred2_log_bilirubin)
PSS008318|
South Asian Ancestry|
5,983 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.5736 [0.5563, 0.5904] sex, age, birth date, deprivation index, 16 PCs
PPM012132 PGS002160
(portability-ldpred2_log_bilirubin)
PSS008095|
East Asian Ancestry|
1,702 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.403 [0.3622, 0.4423] sex, age, birth date, deprivation index, 16 PCs
PPM012133 PGS002160
(portability-ldpred2_log_bilirubin)
PSS007882|
African Ancestry|
2,326 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.4982 [0.4668, 0.5282] sex, age, birth date, deprivation index, 16 PCs
PPM012134 PGS002160
(portability-ldpred2_log_bilirubin)
PSS008986|
African Ancestry|
3,640 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Total bilirubin Partial Correlation (partial-r): 0.4749 [0.4492, 0.4997] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000684 5,007 individuals African unspecified UKB
PSS000685 915 individuals East Asian UKB
PSS000686 20,094 individuals European Non-British White UKB
PSS000687 6,088 individuals South Asian UKB
PSS000688 54,161 individuals European
(British)
UKB
PSS007882 2,326 individuals African American or Afro-Caribbean Carribean UKB
PSS007111 5,082 individuals African unspecified UKB
PSS007112 1,363 individuals East Asian UKB
PSS007113 20,309 individuals European non-white British ancestry UKB
PSS007114 6,150 individuals South Asian UKB
PSS007115 54,944 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS008540 1,120 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009438 18,919 individuals European UK (+ Ireland) UKB
PSS009212 3,930 individuals European Poland (NE Europe) UKB
PSS008318 5,983 individuals South Asian India (South Asia) UKB
PSS000762 5,978 individuals African unspecified UKB
PSS000763 1,069 individuals East Asian UKB
PSS000764 23,472 individuals European Non-British White UKB
PSS000765 7,313 individuals South Asian UKB
PSS000766 63,531 individuals European
(British)
UKB
PSS008986 3,640 individuals African unspecified Nigeria (West Africa) UKB
PSS007191 6,059 individuals African unspecified UKB
PSS007192 1,603 individuals East Asian UKB
PSS007193 23,663 individuals European non-white British ancestry UKB
PSS007194 7,401 individuals South Asian UKB
PSS007195 64,211 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS008095 1,702 individuals East Asian China (East Asia) UKB
PSS008766 6,303 individuals European Italy (South Europe) UKB