Trait: eosinophil count

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004842
Description
  • Is a quantification of eosinphils in blood.
  • The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter.
Trait category
Hematological measurement
Synonym blood eosinophil count
Mapped terms 4 mapped terms
  • CMO:0000033
  • MedDRA:10014941
  • NCIt:C64550
  • SNOMEDCT:71960002
Child trait(s) eosinophil percentage of leukocytes

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "eosinophil count" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000090
(eo)
PGP000051 |
Xu Y et al. Cell Genom (2022)
Eosinophil count eosinophil count 22,949
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000090/ScoringFiles/PGS000090.txt.gz
PGS000091
(eo_p)
PGP000051 |
Xu Y et al. Cell Genom (2022)
Eosinophil percentage of white cells eosinophil percentage of leukocytes 24,406
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000091/ScoringFiles/PGS000091.txt.gz
PGS000165
(eo)
PGP000078 |
Vuckovic D et al. Cell (2020)
Eosinophil count eosinophil count 607
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000165/ScoringFiles/PGS000165.txt.gz
PGS000166
(eo_p)
PGP000078 |
Vuckovic D et al. Cell (2020)
Eosinophil percentage of white cells eosinophil percentage of leukocytes 571
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000166/ScoringFiles/PGS000166.txt.gz
PGS001076
(GBE_INI30210)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Eosinophill % eosinophil percentage of leukocytes 12,563
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001076/ScoringFiles/PGS001076.txt.gz
PGS001172
(GBE_INI30150)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Eosinophill count eosinophil count 12,579
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001172/ScoringFiles/PGS001172.txt.gz
PGS001949
(portability-PLR_log_eosinophil_perc)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Eosinophil percentage eosinophil percentage of leukocytes 9,236
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001949/ScoringFiles/PGS001949.txt.gz
PGS002167
(portability-ldpred2_log_eosinophil_perc)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Eosinophil percentage eosinophil percentage of leukocytes 593,459
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002167/ScoringFiles/PGS002167.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000212 PGS000090
(eo)
PSS000155|
European Ancestry|
81,294 individuals
PGP000051 |
Xu Y et al. Cell Genom (2022)
Reported Trait: Eosinophil count Pearson correlation coefficent (r): 0.40991 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000213 PGS000090
(eo)
PSS000129|
European Ancestry|
40,276 individuals
PGP000051 |
Xu Y et al. Cell Genom (2022)
Reported Trait: Eosinophil count Pearson correlation coefficent (r): 0.39315 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000214 PGS000091
(eo_p)
PSS000156|
European Ancestry|
81,283 individuals
PGP000051 |
Xu Y et al. Cell Genom (2022)
Reported Trait: Eosinophil percentage of white cells Pearson correlation coefficent (r): 0.39099 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000215 PGS000091
(eo_p)
PSS000130|
European Ancestry|
40,326 individuals
PGP000051 |
Xu Y et al. Cell Genom (2022)
Reported Trait: Eosinophil percentage of white cells Pearson correlation coefficent (r): 0.37643 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000547 PGS000165
(eo)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Eosinophil count : 0.06931 sex, age, 10 genetic PCs
PPM000521 PGS000165
(eo)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Eosinophil count : 0.11155 sex, age, 10 genetic PCs
PPM000522 PGS000166
(eo_p)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Eosinophil percentage of white cells : 0.0979 sex, age, 10 genetic PCs
PPM008138 PGS001076
(GBE_INI30210)
PSS007006|
African Ancestry|
6,120 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill % : 0.02749 [0.01965, 0.03533]
Incremental R2 (full-covars): 0.01358
PGS R2 (no covariates): 0.01502 [0.00915, 0.02088]
age, sex, UKB array type, Genotype PCs
PPM008139 PGS001076
(GBE_INI30210)
PSS007007|
East Asian Ancestry|
1,654 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill % : 0.0678 [0.0448, 0.0908]
Incremental R2 (full-covars): 0.03179
PGS R2 (no covariates): 0.03326 [0.01655, 0.04996]
age, sex, UKB array type, Genotype PCs
PPM008140 PGS001076
(GBE_INI30210)
PSS007008|
European Ancestry|
24,130 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill % : 0.10724 [0.09998, 0.1145]
Incremental R2 (full-covars): 0.09158
PGS R2 (no covariates): 0.09579 [0.08884, 0.10274]
age, sex, UKB array type, Genotype PCs
PPM008141 PGS001076
(GBE_INI30210)
PSS007009|
South Asian Ancestry|
7,491 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill % : 0.08004 [0.06852, 0.09157]
Incremental R2 (full-covars): 0.0618
PGS R2 (no covariates): 0.06258 [0.05219, 0.07296]
age, sex, UKB array type, Genotype PCs
PPM008142 PGS001076
(GBE_INI30210)
PSS007010|
European Ancestry|
65,520 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill % : 0.10364 [0.09929, 0.108]
Incremental R2 (full-covars): 0.09566
PGS R2 (no covariates): 0.09594 [0.09171, 0.10016]
age, sex, UKB array type, Genotype PCs
PPM008570 PGS001172
(GBE_INI30150)
PSS006981|
African Ancestry|
6,120 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.02165 [0.01465, 0.02865]
Incremental R2 (full-covars): 0.01273
PGS R2 (no covariates): 0.01483 [0.009, 0.02067]
age, sex, UKB array type, Genotype PCs
PPM008571 PGS001172
(GBE_INI30150)
PSS006982|
East Asian Ancestry|
1,654 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.07017 [0.04683, 0.09352]
Incremental R2 (full-covars): 0.02406
PGS R2 (no covariates): 0.02686 [0.01175, 0.04197]
age, sex, UKB array type, Genotype PCs
PPM008572 PGS001172
(GBE_INI30150)
PSS006983|
European Ancestry|
24,129 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.10592 [0.09869, 0.11315]
Incremental R2 (full-covars): 0.08944
PGS R2 (no covariates): 0.0939 [0.08701, 0.1008]
age, sex, UKB array type, Genotype PCs
PPM008573 PGS001172
(GBE_INI30150)
PSS006984|
South Asian Ancestry|
7,491 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.06486 [0.05432, 0.07541]
Incremental R2 (full-covars): 0.05229
PGS R2 (no covariates): 0.05348 [0.04379, 0.06318]
age, sex, UKB array type, Genotype PCs
PPM008574 PGS001172
(GBE_INI30150)
PSS006985|
European Ancestry|
65,520 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.10264 [0.0983, 0.10698]
Incremental R2 (full-covars): 0.09343
PGS R2 (no covariates): 0.09398 [0.08978, 0.09817]
age, sex, UKB array type, Genotype PCs
PPM010467 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS009442|
European Ancestry|
11,529 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.2072 [0.1897, 0.2246] sex, age, birth date, deprivation index, 16 PCs
PPM010468 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS009216|
European Ancestry|
2,282 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.2342 [0.1949, 0.2728] sex, age, birth date, deprivation index, 16 PCs
PPM010469 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS008770|
European Ancestry|
3,365 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1724 [0.1393, 0.2051] sex, age, birth date, deprivation index, 16 PCs
PPM010470 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS008544|
Greater Middle Eastern Ancestry|
676 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1901 [0.1152, 0.2628] sex, age, birth date, deprivation index, 16 PCs
PPM010471 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS008322|
South Asian Ancestry|
4,224 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1678 [0.1382, 0.197] sex, age, birth date, deprivation index, 16 PCs
PPM010472 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS008099|
East Asian Ancestry|
983 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1291 [0.0665, 0.1907] sex, age, birth date, deprivation index, 16 PCs
PPM010473 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS007886|
African Ancestry|
1,291 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.0617 [0.0067, 0.1162] sex, age, birth date, deprivation index, 16 PCs
PPM010474 PGS001949
(portability-PLR_log_eosinophil_perc)
PSS008990|
African Ancestry|
2,100 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.0967 [0.054, 0.1391] sex, age, birth date, deprivation index, 16 PCs
PPM012184 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS009216|
European Ancestry|
2,282 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.2199 [0.1803, 0.2587] sex, age, birth date, deprivation index, 16 PCs
PPM012185 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS008770|
European Ancestry|
3,365 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1751 [0.142, 0.2077] sex, age, birth date, deprivation index, 16 PCs
PPM012186 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS008544|
Greater Middle Eastern Ancestry|
676 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.18 [0.1049, 0.253] sex, age, birth date, deprivation index, 16 PCs
PPM012187 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS008322|
South Asian Ancestry|
4,224 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1683 [0.1388, 0.1976] sex, age, birth date, deprivation index, 16 PCs
PPM012188 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS008099|
East Asian Ancestry|
983 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.1159 [0.0531, 0.1778] sex, age, birth date, deprivation index, 16 PCs
PPM012189 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS007886|
African Ancestry|
1,291 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.0644 [0.0095, 0.119] sex, age, birth date, deprivation index, 16 PCs
PPM012190 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS008990|
African Ancestry|
2,100 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.091 [0.0482, 0.1335] sex, age, birth date, deprivation index, 16 PCs
PPM012183 PGS002167
(portability-ldpred2_log_eosinophil_perc)
PSS009442|
European Ancestry|
11,529 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Eosinophil percentage Partial Correlation (partial-r): 0.2043 [0.1867, 0.2217] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006981 6,120 individuals African unspecified UKB
PSS006982 1,654 individuals East Asian UKB
PSS006983 24,129 individuals European non-white British ancestry UKB
PSS006984 7,491 individuals South Asian UKB
PSS006985 65,520 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007886 1,291 individuals African American or Afro-Caribbean Carribean UKB
PSS008544 676 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009442 11,529 individuals European UK (+ Ireland) UKB
PSS007006 6,120 individuals African unspecified UKB
PSS007007 1,654 individuals East Asian UKB
PSS007008 24,130 individuals European non-white British ancestry UKB
PSS007009 7,491 individuals South Asian UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS007010 65,520 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009216 2,282 individuals European Poland (NE Europe) UKB
PSS000129 40,276 individuals,
49.0 % Male samples
Mean = 43.84 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000130 40,326 individuals,
49.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL
PSS008322 4,224 individuals South Asian India (South Asia) UKB
PSS000155 81,294 individuals,
46.0 % Male samples
Mean = 57.2 years
Range = [39.98, 72.44] years
European UKB
PSS000156 81,283 individuals,
45.0 % Male samples
Mean = 57.19 years
Range = [38.87, 71.1] years
European UKB
PSS008990 2,100 individuals African unspecified Nigeria (West Africa) UKB
PSS008099 983 individuals East Asian China (East Asia) UKB
PSS008770 3,365 individuals European Italy (South Europe) UKB