Trait: eosinophil count

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004842
Description
  • Is a quantification of eosinphils in blood.
  • The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter.
Trait category
Hematological measurement
Synonyms blood eosinophil count
Mapped term(s) 3 mapped terms
  • CMO:0000033
  • NCIt:C64550
  • SNOMEDCT:71960002
Child trait(s) eosinophil percentage of leukocytes

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "eosinophil count" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000090
(eo)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Eosinophil count eosinophil count 623
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000090/ScoringFiles/PGS000090.txt.gz
PGS000091
(eo_p)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Eosinophil percentage of white cells eosinophil percentage of leukocytes 589
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000091/ScoringFiles/PGS000091.txt.gz
PGS000165
(eo)
PGP000078 |
Vuckovic D et al. Cell (2020)
Eosinophil count eosinophil count 607
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000165/ScoringFiles/PGS000165.txt.gz
PGS000166
(eo_p)
PGP000078 |
Vuckovic D et al. Cell (2020)
Eosinophil percentage of white cells eosinophil percentage of leukocytes 571
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000166/ScoringFiles/PGS000166.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000212 PGS000090
(eo)
PSS000155|
European Ancestry|
81,294 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Eosinophil count Pearson correlation coefficent (r): 0.383 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000213 PGS000090
(eo)
PSS000129|
European Ancestry|
40,276 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Eosinophil count Pearson correlation coefficent (r): 0.3556 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000214 PGS000091
(eo_p)
PSS000156|
European Ancestry|
81,283 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Eosinophil percentage of white cells Pearson correlation coefficent (r): 0.3687 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000215 PGS000091
(eo_p)
PSS000130|
European Ancestry|
40,326 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Eosinophil percentage of white cells Pearson correlation coefficent (r): 0.3412 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000547 PGS000165
(eo)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Eosinophil count : 0.06931 sex, age, 10 genetic PCs
PPM000521 PGS000165
(eo)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Eosinophil count : 0.11155 sex, age, 10 genetic PCs
PPM000522 PGS000166
(eo_p)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Eosinophil percentage of white cells : 0.0979 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS000155 81,294 individuals,
46.0 % Male samples
Mean = 57.2 years
Range = [39.98, 72.44] years
European UKB
PSS000156 81,283 individuals,
45.0 % Male samples
Mean = 57.19 years
Range = [38.87, 71.1] years
European UKB
PSS000129 40,276 individuals,
49.0 % Male samples
Mean = 43.84 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000130 40,326 individuals,
49.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL