Trait: hippocampal volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005035
Description Measurement of the volume of the hippocampus
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001630
(GBE_INI25019)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Volume of hippocampus (L) neuroimaging measurement,
hippocampal volume
442
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001630/ScoringFiles/PGS001630.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005440 PGS001630
(GBE_INI25019)
PSS005276|
African Ancestry|
200 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of hippocampus (L) : 0.13049 [0.11522, 0.14576]
Incremental R2 (full-covars): -0.00825
PGS R2 (no covariates): 0.0 [-0.00005, 0.00005]
age, sex, UKB array type, Genotype PCs
PPM005441 PGS001630
(GBE_INI25019)
PSS005277|
East Asian Ancestry|
113 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of hippocampus (L) : 0.26457 [0.22872, 0.30042]
Incremental R2 (full-covars): 0.01199
PGS R2 (no covariates): 0.0194 [0.00646, 0.03235]
age, sex, UKB array type, Genotype PCs
PPM005442 PGS001630
(GBE_INI25019)
PSS005278|
European Ancestry|
1,739 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of hippocampus (L) : 0.14648 [0.13837, 0.1546]
Incremental R2 (full-covars): 0.00716
PGS R2 (no covariates): 0.00755 [0.00541, 0.00969]
age, sex, UKB array type, Genotype PCs
PPM005443 PGS001630
(GBE_INI25019)
PSS005279|
South Asian Ancestry|
328 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of hippocampus (L) : 0.2658 [0.24904, 0.28256]
Incremental R2 (full-covars): 0.00259
PGS R2 (no covariates): 0.00435 [0.00144, 0.00725]
age, sex, UKB array type, Genotype PCs
PPM005444 PGS001630
(GBE_INI25019)
PSS005280|
European Ancestry|
5,443 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Vol. of hippocampus (L) : 0.11388 [0.10937, 0.11839]
Incremental R2 (full-covars): 0.00801
PGS R2 (no covariates): 0.00917 [0.00774, 0.0106]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005276 200 individuals African unspecified UKB
PSS005277 113 individuals East Asian UKB
PSS005278 1,739 individuals European non-white British ancestry UKB
PSS005279 328 individuals South Asian UKB
PSS005280 5,443 individuals European white British ancestry UKB Testing cohort (heldout set)