Trait: hippocampal CA3 volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009395
Description Volume of hippocampal CA3, which is the part of hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003621
(L_CA3_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA3 body volume hippocampal CA3 volume 20,796
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003621/ScoringFiles/PGS003621.txt.gz
PGS003622
(L_CA3_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA3 head volume hippocampal CA3 volume 14,099
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003622/ScoringFiles/PGS003622.txt.gz
PGS003623
(R_CA3_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA3 body volume hippocampal CA3 volume 9,398
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003623/ScoringFiles/PGS003623.txt.gz
PGS003624
(R_CA3_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA3 head volume hippocampal CA3 volume 594
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003624/ScoringFiles/PGS003624.txt.gz
PGS003625
(L_CA3_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA3 body volume hippocampal CA3 volume 1,034
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003625/ScoringFiles/PGS003625.txt.gz
PGS003626
(L_CA3_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA3 head volume hippocampal CA3 volume 14,199
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003626/ScoringFiles/PGS003626.txt.gz
PGS003627
(R_CA3_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA3 body volume hippocampal CA3 volume 3,205
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003627/ScoringFiles/PGS003627.txt.gz
PGS003628
(R_CA3_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA3 head volume hippocampal CA3 volume 19,760
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003628/ScoringFiles/PGS003628.txt.gz
PGS003629
(L_CA3_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA3 body volume hippocampal CA3 volume 24,206
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003629/ScoringFiles/PGS003629.txt.gz
PGS003630
(L_CA3_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA3 head volume hippocampal CA3 volume 2,341
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003630/ScoringFiles/PGS003630.txt.gz
PGS003631
(R_CA3_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA3 body volume hippocampal CA3 volume 6,731
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003631/ScoringFiles/PGS003631.txt.gz
PGS003632
(R_CA3_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA3 head volume hippocampal CA3 volume 38,665
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003632/ScoringFiles/PGS003632.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018299 PGS003621
(L_CA3_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA3 body volume — — R²: 0.01029 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018304 PGS003622
(L_CA3_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA3 head volume — — R²: 0.01199 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018320 PGS003623
(R_CA3_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA3 body volume — — R²: 0.00959 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018325 PGS003624
(R_CA3_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA3 head volume — — R²: 0.00758 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018343 PGS003625
(L_CA3_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA3 body volume — — R²: 0.00528 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018348 PGS003626
(L_CA3_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA3 head volume — — R²: 0.00737 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018364 PGS003627
(R_CA3_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA3 body volume — — R²: 0.00824 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018369 PGS003628
(R_CA3_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA3 head volume — — R²: 0.0063 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018387 PGS003629
(L_CA3_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA3 body volume — — R²: 0.00577 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018392 PGS003630
(L_CA3_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA3 head volume — — R²: 0.00652 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018408 PGS003631
(R_CA3_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA3 body volume — — R²: 0.00404 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018413 PGS003632
(R_CA3_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA3 head volume — — R²: 0.00322 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010958 — — 1,999 individuals — East Asian — CHIMGEN —