Trait: glioma

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005543
Description A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. [NCIT: C3059]
Trait categories
Neurological disorder
Synonyms 9 synonyms
  • glial neoplasm
  • glial tumor
  • glioma
  • neoplasm of neuroglia
  • neoplasm of the neuroglia
  • neuroglial neoplasm
  • neuroglial tumor
  • tumor of neuroglia
  • tumor of the neuroglia
Mapped terms 8 mapped terms
  • GARD:0006513
  • MESH:D005910
  • NCIT:C3059
  • OMIM:613028
  • OMIM:613029
  • Orphanet:182067
  • SCTID:393564001
  • UMLS:C0017638

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
East Asian
South Asian
Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGP000075 |
Shi Z et al. Cancer Med (2019)
Glioma glioma 19
PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
Glioma brain neoplasm,

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000475 PGS000155
European Ancestry|
14,419 individuals
PGP000075 |
Shi Z et al. Cancer Med (2019)
Reported Trait: Glioma Mean realative risk: 1.22 [1.18, 1.26]
Wilcoxon test (case vs. control) p-value: 1.39e-37
PPM000486 PGS000155
European Ancestry|
14,419 individuals
PGP000075 |
Shi Z et al. Cancer Med (2019)
Reported Trait: Glioma Odds Ratio (OR; high vs. average risk groups): 1.8 [1.55, 2.1]
PPM002036 PGS000781
Multi-ancestry (including European)|
734 individuals
PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
Reported Trait: Pediatric brain tumors OR: 1.25 [1.06, 1.49] : 0.012 Age, sex, country

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001009 Cases include participants with the following tumors: Astrocytomas (ICCC-3 group IIIb), Other gliomas (ICCC-3 group IIId), Ependymomas (ICCC-3 group IIIa), Intracranial embryonal tumors (ICCC-3 group IIIc), other specified intracranial neoplasms (ICCC-3 group IIIe), unspecified intracranial neoplasms (ICCC-3 group IIIf)
  • 245 cases
  • , 489 controls
54.09 % Male samples
European, NR European = 454, NR =280 CEFALO
PSS000275 Primary tumor samples from TCGA
  • 992 cases
  • , 0 controls
Mean = 52.0 years
Sd = 16.0 years
European TCGA
  • 0 cases
  • , 13,427 controls
European eMERGE