Trait: glioma

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005543
Description A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. [NCIT: C3059]
Trait category
Cancer
Neurological disorder
Synonyms 16 synonyms
  • GLIOMA, MALIGNANT
  • Malignant Glial Neoplasm
  • Malignant Glial Tumor
  • Malignant Glioma
  • Malignant Neuroglial Neoplasm
  • Malignant Neuroglial Tumor
  • brain glioma
  • glial neoplasm
  • glial tumor
  • glioma
  • neoplasm of neuroglia
  • neoplasm of the neuroglia
  • neuroglial neoplasm
  • neuroglial tumor
  • tumor of neuroglia
  • tumor of the neuroglia
Mapped term(s) 9 mapped terms
  • DOID:0060108
  • GARD:0006513
  • MESH:D005910
  • NCIT:C3059
  • NCIt:C4822
  • OMIM:613028
  • OMIM:613029
  • SCTID:393564001
  • UMLS:C0017638

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000155
(cGRS_Glioma)
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Glioma glioma 19
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000155/ScoringFiles/PGS000155.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000475 PGS000155
(cGRS_Glioma)
 PSS000275|
European Ancestry|
14,419 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Glioma — — Mean realative risk: 1.22 [1.18, 1.26]
Wilcoxon test (case vs. control) p-value: 1.39e-37		 — —
PPM000486 PGS000155
(cGRS_Glioma)
 PSS000275|
European Ancestry|
14,419 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Glioma — — Odds Ratio (OR; high vs. average risk groups): 1.8 [1.55, 2.1] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000275 Primary tumor samples from TCGA —
[
  • 992 cases
  • , 0 controls
]
 Mean = 52.0 years
Sd = 16.0 years		 European — TCGA —
PSS000275 — —
[
  • 0 cases
  • , 13,427 controls
]
 — European — eMERGE —