Trait: overweight body mass index status

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005935
Description quantification of weight/height relationships above a certain threshold that classes an individual as overweight. This threshold may vary based on an individual's ethnicity but is commonly considered to correspond in European populations to a 25<BMI<30
Trait category
Body measurement
Synonym overweight BMI status

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001825
(portability-PLR_278)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Overweight, obesity and other hyperalimentation overweight body mass index status,
overnutrition,
obesity disorder		 13,009
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001825/ScoringFiles/PGS001825.txt.gz
PGS002033
(portability-ldpred2_278)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Overweight, obesity and other hyperalimentation overweight body mass index status,
overnutrition,
obesity disorder		 846,292
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002033/ScoringFiles/PGS002033.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009497 PGS001825
(portability-PLR_278)
 PSS009295|
European Ancestry|
20,000 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0547 [0.0409, 0.0686] sex, age, birth date, deprivation index, 16 PCs —
PPM009499 PGS001825
(portability-PLR_278)
 PSS008623|
European Ancestry|
6,660 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0516 [0.0276, 0.0756] sex, age, birth date, deprivation index, 16 PCs —
PPM009500 PGS001825
(portability-PLR_278)
 PSS008398|
Greater Middle Eastern Ancestry|
1,200 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0493 [-0.0078, 0.106] sex, age, birth date, deprivation index, 16 PCs —
PPM009501 PGS001825
(portability-PLR_278)
 PSS008177|
South Asian Ancestry|
6,331 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0334 [0.0087, 0.058] sex, age, birth date, deprivation index, 16 PCs —
PPM009502 PGS001825
(portability-PLR_278)
 PSS007963|
East Asian Ancestry|
1,810 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): -0.0049 [-0.0513, 0.0414] sex, age, birth date, deprivation index, 16 PCs —
PPM009503 PGS001825
(portability-PLR_278)
 PSS007744|
African Ancestry|
2,484 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0323 [-0.0072, 0.0717] sex, age, birth date, deprivation index, 16 PCs —
PPM009504 PGS001825
(portability-PLR_278)
 PSS008848|
African Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0208 [-0.0105, 0.0522] sex, age, birth date, deprivation index, 16 PCs —
PPM009498 PGS001825
(portability-PLR_278)
 PSS009069|
European Ancestry|
4,136 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0453 [0.0148, 0.0758] sex, age, birth date, deprivation index, 16 PCs —
PPM011135 PGS002033
(portability-ldpred2_278)
 PSS009295|
European Ancestry|
20,000 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0789 [0.0651, 0.0927] sex, age, birth date, deprivation index, 16 PCs —
PPM011137 PGS002033
(portability-ldpred2_278)
 PSS008623|
European Ancestry|
6,660 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0824 [0.0585, 0.1062] sex, age, birth date, deprivation index, 16 PCs —
PPM011138 PGS002033
(portability-ldpred2_278)
 PSS008398|
Greater Middle Eastern Ancestry|
1,200 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0801 [0.0232, 0.1366] sex, age, birth date, deprivation index, 16 PCs —
PPM011139 PGS002033
(portability-ldpred2_278)
 PSS008177|
South Asian Ancestry|
6,331 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0502 [0.0255, 0.0747] sex, age, birth date, deprivation index, 16 PCs —
PPM011140 PGS002033
(portability-ldpred2_278)
 PSS007963|
East Asian Ancestry|
1,810 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0109 [-0.0354, 0.0572] sex, age, birth date, deprivation index, 16 PCs —
PPM011141 PGS002033
(portability-ldpred2_278)
 PSS007744|
African Ancestry|
2,484 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0265 [-0.013, 0.0659] sex, age, birth date, deprivation index, 16 PCs —
PPM011142 PGS002033
(portability-ldpred2_278)
 PSS008848|
African Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0516 [0.0203, 0.0829] sex, age, birth date, deprivation index, 16 PCs —
PPM011136 PGS002033
(portability-ldpred2_278)
 PSS009069|
European Ancestry|
4,136 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overweight, obesity and other hyperalimentation — — Partial Correlation (partial-r): 0.0523 [0.0218, 0.0827] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009069 — — 4,136 individuals — European Poland (NE Europe) UKB —
PSS008398 — — 1,200 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009295 — — 20,000 individuals — European UK (+ Ireland) UKB —
PSS008623 — — 6,660 individuals — European Italy (South Europe) UKB —
PSS008177 — — 6,331 individuals — South Asian India (South Asia) UKB —
PSS008848 — — 3,924 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007963 — — 1,810 individuals — East Asian China (East Asia) UKB —
PSS007744 — — 2,484 individuals — African American or Afro-Caribbean Carribean UKB —