Trait: mean arterial pressure

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006340
Description The mean pressure of the blood within the arterial circulation. The arterial pressure may be directly measured by insertion of an intra-arterial catheter connected to a transducer. The mean arterial pressure (MAP) can be calculated by subsequent analysis of the waveform. MAP can be approximated without an invasive procedure using the following formula: diastolic pressure plus 1/3 of the pulse pressure, where pulse pressure is systolic pressure - diastolic pressure.
Trait category
Cardiovascular measurement
Synonym MAP
Mapped terms 2 mapped terms
  • MedDRA:10026982
  • NCIt:C49679

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003476
(LDPred2_MAP)
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Mean arterial pressure mean arterial pressure 739,104
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003476/ScoringFiles/PGS003476.txt.gz
PGS019802
(TPMI_MAP_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mean arterial pressure mean arterial pressure 54,942
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019802/ScoringFiles/PGS019802.txt.gz
PGS019826
(TPMI_MAP_LDPred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mean arterial pressure mean arterial pressure 939,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019826/ScoringFiles/PGS019826.txt.gz
PGS019850
(TPMI_MAP_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mean arterial pressure mean arterial pressure 983,786
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019850/ScoringFiles/PGS019850.txt.gz
PGS019874
(TPMI_MAP_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mean arterial pressure mean arterial pressure 481,289
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019874/ScoringFiles/PGS019874.txt.gz
PGS019898
(TPMI_MAP_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mean arterial pressure mean arterial pressure 433,422
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019898/ScoringFiles/PGS019898.txt.gz
PGS019913
(TPMI_MAP_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mean arterial pressure mean arterial pressure 1,071,465
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019913/ScoringFiles/PGS019913.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017286 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index β: 0.007 (0.01) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017309 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea β: -0.006 (0.024) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017352 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in obsese β: 0.025 (0.017) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017353 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in non-obsese β: -0.009 (0.012) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017372 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in obsese β: 0.042 (0.034) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017373 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in non-obsese β: -0.061 (0.034) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017398 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index x obesity interaction β: 0.028 (1.028) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017408 PGS003476
(LDPred2_MAP)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea x obesity interaction β: 1.09 (0.049) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM037984 PGS019802
(TPMI_MAP_Lassosum2)
 PSS013761|
East Asian Ancestry|
9,471 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mean arterial pressure — AUROC: 0.74612 R²: 0.04088 sex, age, array, PCs 1-10 —
PPM038008 PGS019826
(TPMI_MAP_LDPred2)
 PSS013760|
East Asian Ancestry|
9,471 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mean arterial pressure — AUROC: 0.78188 R²: 0.05365 sex, age, array, PCs 1-10 —
PPM038032 PGS019850
(TPMI_MAP_PRS-CS)
 PSS013763|
East Asian Ancestry|
9,471 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mean arterial pressure — — R²: 0.05213 sex, age, array, PCs 1-10 —
PPM038056 PGS019874
(TPMI_MAP_SBayesR)
 PSS013765|
East Asian Ancestry|
9,471 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mean arterial pressure — AUROC: 0.77598 R²: 0.02857 sex, age, array, PCs 1-10 —
PPM038080 PGS019898
(TPMI_MAP_MegaPRS)
 PSS013762|
East Asian Ancestry|
9,471 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mean arterial pressure — AUROC: 0.75415 R²: 0.03883 sex, age, array, PCs 1-10 —
PPM038095 PGS019913
(TPMI_MAP_PRSmix+)
 PSS013764|
East Asian Ancestry|
9,471 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mean arterial pressure — AUROC: 0.69005 R²: 0.06341 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013760 — — 9,471 individuals,
41.74 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013761 — — 9,471 individuals,
41.74 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013762 — — 9,471 individuals,
41.74 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013763 — — 9,471 individuals,
41.74 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013764 — — 9,471 individuals,
41.74 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013765 — — 9,471 individuals,
41.74 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS-SOL —