Trait: grip strength measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006941
Description quantification of the force applied by the hand to pull on or suspend from objects
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001119
(GBE_INI46)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Left hand grip strength grip strength measurement 13,767
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001119/ScoringFiles/PGS001119.txt.gz
PGS001120
(GBE_INI47)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Right hand grip strength grip strength measurement 12,644
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001120/ScoringFiles/PGS001120.txt.gz
PGS001927
(portability-PLR_hand_grip_strength)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Hand grip strength (mean of both) grip strength measurement 73,846
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001927/ScoringFiles/PGS001927.txt.gz
PGS002143
(portability-ldpred2_hand_grip_strength)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Hand grip strength (mean of both) grip strength measurement 966,283
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002143/ScoringFiles/PGS002143.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008333 PGS001119
(GBE_INI46)
PSS007346|
African Ancestry|
6,406 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (L) : 0.46137 [0.44358, 0.47915]
Incremental R2 (full-covars): -0.00082
PGS R2 (no covariates): 0.00155 [-0.00036, 0.00346]
age, sex, UKB array type, Genotype PCs
PPM008334 PGS001119
(GBE_INI46)
PSS007347|
East Asian Ancestry|
1,696 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (L) : 0.51785 [0.48497, 0.55073]
Incremental R2 (full-covars): 0.00522
PGS R2 (no covariates): 0.01076 [0.00104, 0.02048]
age, sex, UKB array type, Genotype PCs
PPM008335 PGS001119
(GBE_INI46)
PSS007348|
European Ancestry|
24,787 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (L) : 0.54413 [0.53578, 0.55248]
Incremental R2 (full-covars): 0.01167
PGS R2 (no covariates): 0.01075 [0.0082, 0.01329]
age, sex, UKB array type, Genotype PCs
PPM008336 PGS001119
(GBE_INI46)
PSS007349|
South Asian Ancestry|
7,727 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (L) : 0.48797 [0.47214, 0.50381]
Incremental R2 (full-covars): 0.00538
PGS R2 (no covariates): 0.00871 [0.00462, 0.01281]
age, sex, UKB array type, Genotype PCs
PPM008337 PGS001119
(GBE_INI46)
PSS007350|
European Ancestry|
67,154 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (L) : 0.57766 [0.57281, 0.5825]
Incremental R2 (full-covars): 0.01506
PGS R2 (no covariates): 0.01441 [0.01262, 0.0162]
age, sex, UKB array type, Genotype PCs
PPM008338 PGS001120
(GBE_INI47)
PSS007351|
African Ancestry|
6,401 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (R) : 0.46894 [0.45127, 0.48662]
Incremental R2 (full-covars): 0.00206
PGS R2 (no covariates): 0.00239 [0.00002, 0.00476]
age, sex, UKB array type, Genotype PCs
PPM008339 PGS001120
(GBE_INI47)
PSS007352|
East Asian Ancestry|
1,696 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (R) : 0.52807 [0.49557, 0.56056]
Incremental R2 (full-covars): 0.00381
PGS R2 (no covariates): 0.00613 [-0.00124, 0.01351]
age, sex, UKB array type, Genotype PCs
PPM008340 PGS001120
(GBE_INI47)
PSS007353|
European Ancestry|
24,789 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (R) : 0.55224 [0.54398, 0.5605]
Incremental R2 (full-covars): 0.01267
PGS R2 (no covariates): 0.01229 [0.00957, 0.01501]
age, sex, UKB array type, Genotype PCs
PPM008341 PGS001120
(GBE_INI47)
PSS007354|
South Asian Ancestry|
7,741 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (R) : 0.48203 [0.46611, 0.49796]
Incremental R2 (full-covars): 0.00822
PGS R2 (no covariates): 0.00897 [0.00481, 0.01312]
age, sex, UKB array type, Genotype PCs
PPM008342 PGS001120
(GBE_INI47)
PSS007355|
European Ancestry|
67,185 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hand grip strength (R) : 0.57637 [0.57152, 0.58123]
Incremental R2 (full-covars): 0.01651
PGS R2 (no covariates): 0.01531 [0.01347, 0.01715]
age, sex, UKB array type, Genotype PCs
PPM010291 PGS001927
(portability-PLR_hand_grip_strength)
PSS009413|
European Ancestry|
19,855 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.2515 [0.2384, 0.2645] sex, age, birth date, deprivation index, 16 PCs
PPM010292 PGS001927
(portability-PLR_hand_grip_strength)
PSS009187|
European Ancestry|
4,105 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.2485 [0.2195, 0.2771] sex, age, birth date, deprivation index, 16 PCs
PPM010293 PGS001927
(portability-PLR_hand_grip_strength)
PSS008741|
European Ancestry|
6,598 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.2292 [0.2062, 0.252] sex, age, birth date, deprivation index, 16 PCs
PPM010294 PGS001927
(portability-PLR_hand_grip_strength)
PSS008515|
Greater Middle Eastern Ancestry|
1,168 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.1973 [0.1411, 0.2523] sex, age, birth date, deprivation index, 16 PCs
PPM010296 PGS001927
(portability-PLR_hand_grip_strength)
PSS008070|
East Asian Ancestry|
1,799 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.1616 [0.116, 0.2065] sex, age, birth date, deprivation index, 16 PCs
PPM010297 PGS001927
(portability-PLR_hand_grip_strength)
PSS007857|
African Ancestry|
2,448 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.0843 [0.0446, 0.1236] sex, age, birth date, deprivation index, 16 PCs
PPM010298 PGS001927
(portability-PLR_hand_grip_strength)
PSS008961|
African Ancestry|
3,849 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.0651 [0.0334, 0.0965] sex, age, birth date, deprivation index, 16 PCs
PPM010295 PGS001927
(portability-PLR_hand_grip_strength)
PSS008293|
South Asian Ancestry|
6,223 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.1688 [0.1445, 0.1929] sex, age, birth date, deprivation index, 16 PCs
PPM011995 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS008293|
South Asian Ancestry|
6,223 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.1759 [0.1517, 0.1999] sex, age, birth date, deprivation index, 16 PCs
PPM011991 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS009413|
European Ancestry|
19,855 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.262 [0.249, 0.2749] sex, age, birth date, deprivation index, 16 PCs
PPM011992 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS009187|
European Ancestry|
4,105 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.2543 [0.2254, 0.2827] sex, age, birth date, deprivation index, 16 PCs
PPM011993 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS008741|
European Ancestry|
6,598 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.2433 [0.2204, 0.2659] sex, age, birth date, deprivation index, 16 PCs
PPM011994 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS008515|
Greater Middle Eastern Ancestry|
1,168 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.2026 [0.1465, 0.2575] sex, age, birth date, deprivation index, 16 PCs
PPM011996 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS008070|
East Asian Ancestry|
1,799 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.1631 [0.1175, 0.208] sex, age, birth date, deprivation index, 16 PCs
PPM011997 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS007857|
African Ancestry|
2,448 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.0966 [0.0571, 0.1359] sex, age, birth date, deprivation index, 16 PCs
PPM011998 PGS002143
(portability-ldpred2_hand_grip_strength)
PSS008961|
African Ancestry|
3,849 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hand grip strength (mean of both) Partial Correlation (partial-r): 0.0798 [0.0482, 0.1112] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009413 19,855 individuals European UK (+ Ireland) UKB
PSS008741 6,598 individuals European Italy (South Europe) UKB
PSS008070 1,799 individuals East Asian China (East Asia) UKB
PSS008293 6,223 individuals South Asian India (South Asia) UKB
PSS008515 1,168 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009187 4,105 individuals European Poland (NE Europe) UKB
PSS008961 3,849 individuals African unspecified Nigeria (West Africa) UKB
PSS007857 2,448 individuals African American or Afro-Caribbean Carribean UKB
PSS007346 6,406 individuals African unspecified UKB
PSS007347 1,696 individuals East Asian UKB
PSS007348 24,787 individuals European non-white British ancestry UKB
PSS007349 7,727 individuals South Asian UKB
PSS007350 67,154 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007351 6,401 individuals African unspecified UKB
PSS007352 1,696 individuals East Asian UKB
PSS007353 24,789 individuals European non-white British ancestry UKB
PSS007354 7,741 individuals South Asian UKB
PSS007355 67,185 individuals European white British ancestry UKB Testing cohort (heldout set)