Trait: calcaneal bone quantitative ultrasound measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007772
Description
  • bone quantitiave ultrasound of the main bone in the heel, recognized as a non-invasive method for evaluation of bone strength and prediction of osteoporotic fracture
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000657
(gSOS)
PGP000120 |
Forgetta V et al. PLoS Med (2020)
Heel quantitative ultrasound speed of sound (SOS) calcaneal bone quantitative ultrasound measurement 21,717
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001343 PGS000657
(gSOS)
PSS000586|
European Ancestry|
4,741 individuals
PGP000120 |
Forgetta V et al. PLoS Med (2020)
Reported Trait: Heel bone speed of sound : 0.2318 [0.2266, 0.2369]
PPM001344 PGS000657
(gSOS)
PSS000585|
Multi-ancestry (including European)|
21,408 individuals
PGP000120 |
Forgetta V et al. PLoS Med (2020)
Reported Trait: Screening incorporating a gSOS-based screening step Positive Predictive Value (PPV): 0.954
Reduction in individuals requiring Clinical-Risk-Factor FRAX tests (%): 37.0
Percent reduction in individuals requiring BMD FRAX Tests (%): 41.0
PPM001893 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] Age, sex, measured femoral neck bone mineral density
PPM001867 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.66, 0.79] Age, sex
PPM001852 PGS000657
(gSOS)
PSS000937|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.65, 0.71]
PPM001853 PGS000657
(gSOS)
PSS000937|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.64, 0.73] Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS
PPM001854 PGS000657
(gSOS)
PSS000936|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.67, 0.87] Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] Basline fracture risk (FRAX), fracture-related drug use
PPM001855 PGS000657
(gSOS)
PSS000936|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.64, 0.78]
PPM001856 PGS000657
(gSOS)
PSS000936|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.64, 0.89] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS
PPM001857 PGS000657
(gSOS)
PSS000933|
European Ancestry|
12,678 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture in fracture-related drug users OR: 0.78 [0.68, 0.88] Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] Basline fracture risk (FRAX)
PPM001858 PGS000657
(gSOS)
PSS000932|
European Ancestry|
12,678 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: incident hip fracture in fracture-related drug users OR: 0.77 [0.61, 0.98] Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] Basline fracture risk (FRAX)
PPM001859 PGS000657
(gSOS)
PSS000935|
European Ancestry|
67,336 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs OR: 0.57 [0.54, 0.61] Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] Basline fracture risk (FRAX)
PPM001860 PGS000657
(gSOS)
PSS000934|
European Ancestry|
67,336 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs OR: 0.36 [0.3, 0.43] Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] Basline fracture risk (FRAX)
PPM001861 PGS000657
(gSOS)
PSS000951|
European Ancestry|
90,172 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture AUROC: 0.734 [0.727, 0.74] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.68 [1.47, 1.89] Age, sex
PPM001862 PGS000657
(gSOS)
PSS000950|
European Ancestry|
90,172 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture AUROC: 0.798 [0.791, 0.805] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.2 [1.02, 1.41] Age, sex
PPM001863 PGS000657
(gSOS)
PSS000944|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture C-index: 0.623 [0.603, 0.642] Sex
PPM001864 PGS000657
(gSOS)
PSS000943|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture C-index: 0.672 [0.65, 0.695] Sex
PPM001865 PGS000657
(gSOS)
PSS000948|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.65, 0.72] AUROC: 0.68 [0.673, 0.688] Age, sex
PPM001868 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.76 [0.69, 0.85] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001869 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.61, 0.78] Age, sex
PPM001870 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.61, 0.85] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001871 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.68, 0.81] Age, sex
PPM001872 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.68, 0.83] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001873 PGS000657
(gSOS)
PSS000938|
East Asian Ancestry|
25,034 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.79 [0.71, 0.88] Age, sex Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001874 PGS000657
(gSOS)
PSS000938|
East Asian Ancestry|
25,034 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.74, 0.92] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001875 PGS000657
(gSOS)
PSS000947|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.73 [0.63, 0.84] AUROC: 0.739 [0.724, 0.754] Age, sex
PPM001876 PGS000657
(gSOS)
PSS000947|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.86] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001877 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.73 [0.64, 0.83] Age, sex
PPM001878 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.87] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001879 PGS000657
(gSOS)
PSS000939|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.63, 0.93] Age, sex
PPM001880 PGS000657
(gSOS)
PSS000939|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.58, 0.95] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001881 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.7, 0.84] Age, sex
PPM001882 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.84] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001883 PGS000657
(gSOS)
PSS000949|
European Ancestry|
4,717 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.71 [0.59, 0.85] Clinical risk factor-based score (FRAX-CRF)
PPM001884 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.67, 0.81] Clinical risk factor-based score (FRAX-CRF)
PPM001885 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.63, 0.81] Clinical risk factor-based score (FRAX-CRF)
PPM001886 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.77 [0.7, 0.84] Clinical risk factor-based score (FRAX-CRF)
PPM001887 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.65, 0.83] Clinical risk factor-based score (FRAX-CRF)
PPM001888 PGS000657
(gSOS)
PSS000939|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.8 [0.67, 0.96] Clinical risk factor-based score (FRAX-CRF)
PPM001889 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.69, 0.84] Clinical risk factor-based score (FRAX-CRF)
PPM001890 PGS000657
(gSOS)
PSS000949|
European Ancestry|
4,717 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.9] Age, sex, measured femoral neck bone mineral density
PPM001891 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] Age, sex, measured femoral neck bone mineral density
PPM001892 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.68, 0.88] Age, sex, measured femoral neck bone mineral density
PPM001894 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.85 [0.75, 0.97] Age, sex, measured femoral neck bone mineral density
PPM001895 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.83 [0.76, 0.93] Age, sex, measured femoral neck bone mineral density
PPM001896 PGS000657
(gSOS)
PSS000949|
European Ancestry|
4,717 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.89] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001897 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.71, 0.85] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001898 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.66, 0.85] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001899 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.89] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001900 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.87] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001901 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.8 [0.73, 0.88] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001902 PGS000657
(gSOS)
PSS000944|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture C-index: 0.66 [0.641, 0.679] Clinical risk factor-based score (FRAX-CRF)
PPM001903 PGS000657
(gSOS)
PSS000943|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture C-index: 0.682 [0.66, 0.704] Clinical risk factor-based score (FRAX-CRF)
PPM001851 PGS000657
(gSOS)
PSS000937|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] Basline fracture risk (FRAX), fracture-related drug use
PPM001866 PGS000657
(gSOS)
PSS000948|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000940 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit.
[
  • 337 cases
  • , 1,543 controls
]
,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
European MrOS-SWE
PSS000941 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 273 cases
  • , 4,390 controls
]
,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000942 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 560 cases
  • , 4,103 controls
]
,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000943 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 829 cases
  • , 7,449 controls
]
,
56.33 % Male samples
European MrOS-USA, SOF
PSS000944 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,267 cases
  • , 7,011 controls
]
,
56.33 % Male samples
European MrOS-USA, SOF
PSS000945 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 556 cases
  • , 3,059 controls
]
,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European SOF
PSS000946 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 707 cases
  • , 2,908 controls
]
,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European SOF
PSS000947 Cases included individuals with a hip fracture that occurred after the baseline visit.
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB
PSS000948 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722.
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB
PSS000949 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722.
[
  • 125 cases
  • , 4,592 controls
]
European UKB
PSS000950 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,167 cases
  • , 89,005 controls
]
,
31.61 % Male samples
European MrOS-SWE, MrOS-USA, SOF, UKB
PSS000951 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. UKB cohort: Sitespecific major osteoporotic fractures were defined basedon ICD10 codes of primary diagnoses (M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722) and self-reported medical history. Range = [4.5, 14.5] years
[
  • 2,793 cases
  • , 87,379 controls
]
,
31.61 % Male samples
European MrOS-SWE, MrOS-USA, SOF, UKB
PSS000585 4,741 individuals,
47.5 % Male samples
Mean = 55.8 years
Sd = 7.6 years
European UKB
PSS000585 6,704 individuals,
49.3 % Male samples
Mean = 62.6 years
Sd = 9.9 years
European, NR CLSA
PSS000585 3,426 individuals,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European, NR SOF
PSS000585 4,657 individuals,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000585 1,880 individuals,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
European
(Swedish)
MrOS-SWE
PSS000586 4,741 individuals,
47.5 % Male samples
Mean = 55.8 years
Sd = 7.6 years
European UKB
PSS000932 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 68 cases
  • , 12,610 controls
]
,
40.52 % Male samples
Mean = 58.6 years
Sd = 7.7 years
European UKB
PSS000933 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 256 cases
  • , 12,422 controls
]
,
40.52 % Male samples
Mean = 58.6 years
Sd = 7.6 years
European UKB
PSS000934 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322
[
  • 141 cases
  • , 67,195 controls
]
,
46.27 % Male samples
Mean = 56.5 years
Sd = 8.2 years
European UKB
PSS000935 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321
[
  • 933 cases
  • , 66,403 controls
]
,
46.27 % Male samples
Mean = 56.5 years
Sd = 8.1 years
European UKB
PSS000936 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.1 years
European UKB
PSS000937 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB
PSS000938 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit.
[
  • 323 cases
  • , 24,711 controls
]
,
42.7 % Male samples
Mean = 53.7 years
Sd = 11.0 years
East Asian CKB
PSS000939 Cases included individuals with a hip fracture that occurred after the baseline visit.
[
  • 129 cases
  • , 1,751 controls
]
,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
European MrOS-SWE