Trait: monocyte percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007989
Description
  • A calculated measurement in which the number of monocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • blood monocyte count to total leukocyte count ratio
  • monocyte count as percentage of total white blood cells
  • monocyte count to total WBC count ratio
  • monocyte percentage
  • monocyte percentage of white cells
Mapped term(s) CMO:0000374

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000103
(mono_p)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Monocyte percentage of white cells monocyte percentage of leukocytes 583
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000103/ScoringFiles/PGS000103.txt.gz
PGS000178
(mono_p)
PGP000078 |
Vuckovic D et al. Cell (2020)
Monocyte percentage of white cells monocyte percentage of leukocytes 549
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000178/ScoringFiles/PGS000178.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000534 PGS000178
(mono_p)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Monocyte percentage of white cells : 0.14461 sex, age, 10 genetic PCs
PPM000239 PGS000103
(mono_p)
PSS000142|
European Ancestry|
39,189 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Monocyte percentage of white cells Pearson correlation coefficent (r): 0.4207 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000238 PGS000103
(mono_p)
PSS000168|
European Ancestry|
80,627 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Monocyte percentage of white cells Pearson correlation coefficent (r): 0.4395 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000142 39,189 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000168 80,627 individuals,
46.0 % Male samples
Mean = 57.23 years
Range = [40.19, 71.1] years
European UKB
PSS000291 39,260 individuals European INTERVAL