Trait: neutrophil percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007990
Description A calculated measurement in which the number of neutrophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • blood neutrophil count to total leukocyte count ratio
  • neutrophil count as percentage of total white blood cells
  • neutrophil count to total WBC count ratio
  • neutrophil percentage
  • neutrophil percentage of white cells
Mapped term CMO:0000370

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000106
(neut_p)
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Neutrophil percentage of white cells neutrophil percentage of leukocytes 22,049
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000106/ScoringFiles/PGS000106.txt.gz
PGS000183
(neut_p)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Neutrophil percentage of white cells neutrophil percentage of leukocytes 437
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000183/ScoringFiles/PGS000183.txt.gz
PGS001077
(GBE_INI30200)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Neutrophil percentage neutrophil percentage of leukocytes 13,703
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001077/ScoringFiles/PGS001077.txt.gz
PGS001997
(portability-PLR_neutrophil_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Neutrophil percentage neutrophil percentage of leukocytes 65,022
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001997/ScoringFiles/PGS001997.txt.gz
PGS002214
(portability-ldpred2_neutrophil_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Neutrophil percentage neutrophil percentage of leukocytes 769,542
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002214/ScoringFiles/PGS002214.txt.gz
PGS003566
(cont-decay-neutrophil_perc)
 PGP000457 |
Ding Y et al. Nature (2023)
 Neutrophil percentage neutrophil percentage of leukocytes 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003566/ScoringFiles/PGS003566.txt.gz
PGS003943
(INI30200)
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Neutrophil percentage neutrophil percentage of leukocytes 16,931
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003943/ScoringFiles/PGS003943.txt.gz
PGS004361
(X30200.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Neutrophill percentage neutrophil percentage of leukocytes 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004361/ScoringFiles/PGS004361.txt.gz
PGS005192
(VPGS_NEUT_P)
 PGP000723 |
Xiang R et al. Nat Commun (2025)
 Neutrophil percentage of white cells variance neutrophil percentage of leukocytes 9,499,990
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005192/ScoringFiles/PGS005192.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000244 PGS000106
(neut_p)
 PSS000171|
European Ancestry|
81,423 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Neutrophil percentage of white cells — — Pearson correlation coefficent (r): 0.32169 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000245 PGS000106
(neut_p)
 PSS000145|
European Ancestry|
39,190 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Neutrophil percentage of white cells — — Pearson correlation coefficent (r): 0.31935 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) —
PPM000537 PGS000183
(neut_p)
 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Neutrophil percentage of white cells — — R²: 0.06432 sex, age, 10 genetic PCs —
PPM008143 PGS001077
(GBE_INI30200)
 PSS007001|
African Ancestry|
6,120 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — Incremental R2 (full-covars): 0.01344
R²: 0.04156 [0.03206, 0.05106]
PGS R2 (no covariates): 0.01383 [0.00819, 0.01946]		 age, sex, UKB array type, Genotype PCs —
PPM008144 PGS001077
(GBE_INI30200)
 PSS007002|
East Asian Ancestry|
1,654 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.07662 [0.0524, 0.10084]
Incremental R2 (full-covars): 0.04345
PGS R2 (no covariates): 0.04564 [0.02632, 0.06496]		 age, sex, UKB array type, Genotype PCs —
PPM008145 PGS001077
(GBE_INI30200)
 PSS007003|
European Ancestry|
24,130 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.07418 [0.06792, 0.08044]
Incremental R2 (full-covars): 0.07151
PGS R2 (no covariates): 0.07289 [0.06667, 0.0791]		 age, sex, UKB array type, Genotype PCs —
PPM008146 PGS001077
(GBE_INI30200)
 PSS007004|
South Asian Ancestry|
7,491 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.05036 [0.04093, 0.0598]
Incremental R2 (full-covars): 0.04554
PGS R2 (no covariates): 0.04441 [0.03549, 0.05333]		 age, sex, UKB array type, Genotype PCs —
PPM008147 PGS001077
(GBE_INI30200)
 PSS007005|
European Ancestry|
65,520 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.08175 [0.07779, 0.08572]
Incremental R2 (full-covars): 0.07935
PGS R2 (no covariates): 0.07934 [0.07542, 0.08325]		 age, sex, UKB array type, Genotype PCs —
PPM010852 PGS001997
(portability-PLR_neutrophil_perc)
 PSS009254|
European Ancestry|
3,988 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2971 [0.2684, 0.3252] sex, age, birth date, deprivation index, 16 PCs —
PPM010853 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008808|
European Ancestry|
6,413 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2972 [0.2747, 0.3194] sex, age, birth date, deprivation index, 16 PCs —
PPM010854 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008582|
Greater Middle Eastern Ancestry|
1,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2921 [0.2377, 0.3446] sex, age, birth date, deprivation index, 16 PCs —
PPM010855 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008360|
South Asian Ancestry|
6,055 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2672 [0.2436, 0.2904] sex, age, birth date, deprivation index, 16 PCs —
PPM010856 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008137|
East Asian Ancestry|
1,760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2332 [0.1882, 0.2771] sex, age, birth date, deprivation index, 16 PCs —
PPM010857 PGS001997
(portability-PLR_neutrophil_perc)
 PSS007924|
African Ancestry|
2,334 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.166 [0.1261, 0.2054] sex, age, birth date, deprivation index, 16 PCs —
PPM010858 PGS001997
(portability-PLR_neutrophil_perc)
 PSS009028|
African Ancestry|
3,681 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.1587 [0.1269, 0.1901] sex, age, birth date, deprivation index, 16 PCs —
PPM010851 PGS001997
(portability-PLR_neutrophil_perc)
 PSS009480|
European Ancestry|
19,359 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.3059 [0.293, 0.3186] sex, age, birth date, deprivation index, 16 PCs —
PPM012559 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS009480|
European Ancestry|
19,359 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.3042 [0.2913, 0.3169] sex, age, birth date, deprivation index, 16 PCs —
PPM012560 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS009254|
European Ancestry|
3,988 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2993 [0.2707, 0.3274] sex, age, birth date, deprivation index, 16 PCs —
PPM012561 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008808|
European Ancestry|
6,413 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2906 [0.268, 0.3129] sex, age, birth date, deprivation index, 16 PCs —
PPM012562 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008582|
Greater Middle Eastern Ancestry|
1,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2984 [0.2443, 0.3507] sex, age, birth date, deprivation index, 16 PCs —
PPM012563 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008360|
South Asian Ancestry|
6,055 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2641 [0.2405, 0.2874] sex, age, birth date, deprivation index, 16 PCs —
PPM012564 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008137|
East Asian Ancestry|
1,760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2471 [0.2025, 0.2907] sex, age, birth date, deprivation index, 16 PCs —
PPM012565 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS007924|
African Ancestry|
2,334 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.1602 [0.1202, 0.1996] sex, age, birth date, deprivation index, 16 PCs —
PPM012566 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS009028|
African Ancestry|
3,681 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.1568 [0.125, 0.1882] sex, age, birth date, deprivation index, 16 PCs —
PPM017494 PGS003566
(cont-decay-neutrophil_perc)
 PSS010933|
European Ancestry|
19,342 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM017662 PGS003566
(cont-decay-neutrophil_perc)
 PSS010681|
European Ancestry|
6,254 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.08 sex, age, deprivation index, PC1-16 —
PPM017746 PGS003566
(cont-decay-neutrophil_perc)
 PSS010597|
Greater Middle Eastern Ancestry|
1,117 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM017830 PGS003566
(cont-decay-neutrophil_perc)
 PSS010261|
European Ancestry|
2,256 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM017914 PGS003566
(cont-decay-neutrophil_perc)
 PSS010513|
South Asian Ancestry|
6,003 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM017998 PGS003566
(cont-decay-neutrophil_perc)
 PSS010429|
East Asian Ancestry|
1,748 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM018082 PGS003566
(cont-decay-neutrophil_perc)
 PSS010345|
African Ancestry|
2,321 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018166 PGS003566
(cont-decay-neutrophil_perc)
 PSS010765|
African Ancestry|
3,652 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017578 PGS003566
(cont-decay-neutrophil_perc)
 PSS010849|
European Ancestry|
3,977 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Neutrophil percentage — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM019034 PGS003943
(INI30200)
 PSS011139|
European Ancestry|
65,814 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Neutrophil percentage — — R²: 0.0952 [0.091, 0.09941]
PGS R2 (no covariates): 0.08263 [0.07866, 0.0866]
Incremental R2 (full-covars): 0.08285		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019035 PGS003943
(INI30200)
 PSS011110|
European Ancestry|
2,810 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Neutrophil percentage — — R²: 0.08975 [0.0699, 0.10959]
PGS R2 (no covariates): 0.08096 [0.06193, 0.09999]
Incremental R2 (full-covars): 0.08129		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019037 PGS003943
(INI30200)
 PSS011154|
African Ancestry|
1,154 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Neutrophil percentage — — R²: 0.06709 [0.03997, 0.09421]
PGS R2 (no covariates): 0.04252 [0.02036, 0.06467]
Incremental R2 (full-covars): 0.03641		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019038 PGS003943
(INI30200)
 PSS011168|
Multi-ancestry (excluding European)|
7,732 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Neutrophil percentage — — R²: 0.1212 [0.1078, 0.1346]
PGS R2 (no covariates): 0.09346 [0.08132, 0.10559]
Incremental R2 (full-covars): 0.06663		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019036 PGS003943
(INI30200)
 PSS011112|
South Asian Ancestry|
1,428 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Neutrophil percentage — — R²: 0.05999 [0.03664, 0.08334]
PGS R2 (no covariates): 0.04709 [0.02612, 0.06807]
Incremental R2 (full-covars): 0.04754		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM020476 PGS004361
(X30200.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Neutrophill percentage — — PGS R2 (no covariates): 0.20984 — —
PPM022551 PGS005192
(VPGS_NEUT_P)
 PSS012004|
European Ancestry|
39,190 individuals
 PGP000723 |
Xiang R et al. Nat Commun (2025)
 Reported Trait: Neutrophil_percentage_of_white_cells β: 0.00044 — R²: 0.10175 — effects of PGS*vPGS tested and shown in Supplementary Data 12)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009028 — — 3,681 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008137 — — 1,760 individuals — East Asian China (East Asia) UKB —
PSS011154 — — 1,154 individuals — African unspecified — UKB —
PSS010933 — — 19,342 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010681 — — 6,254 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS011168 — — 7,732 individuals — East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB —
PSS007001 — — 6,120 individuals — African unspecified — UKB —
PSS007002 — — 1,654 individuals — East Asian — UKB —
PSS007003 — — 24,130 individuals — European non-white British ancestry UKB —
PSS007004 — — 7,491 individuals — South Asian — UKB —
PSS007005 — — 65,520 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010429 — — 1,748 individuals,
33.0 % Male samples
 Mean = 52.5 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS012004 — — 39,190 individuals — European
(British)		 — INTERVAL —
PSS008808 — — 6,413 individuals — European Italy (South Europe) UKB —
PSS000291 — — 39,260 individuals — European — INTERVAL —
PSS007924 — — 2,334 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008582 — — 1,147 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS010849 — — 3,977 individuals,
38.0 % Male samples
 Mean = 54.3 years
Sd = 7.5 years		 European Polish UKB —
PSS009480 — — 19,359 individuals — European UK (+ Ireland) UKB —
PSS010597 — — 1,117 individuals,
59.0 % Male samples
 Mean = 52.0 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010345 — — 2,321 individuals,
36.0 % Male samples
 Mean = 52.4 years
Sd = 8.0 years		 African American or Afro-Caribbean Caribbean UKB —
PSS000145 — — 39,190 individuals,
50.0 % Male samples
 Mean = 43.83 years
Range = [18.0, 76.4] years		 European — INTERVAL —
PSS011364 — — 56,192 individuals — European — UKB —
PSS009254 — — 3,988 individuals — European Poland (NE Europe) UKB —
PSS011110 — — 2,810 individuals — European
(non-white British ancestry)		 — UKB —
PSS008360 — — 6,055 individuals — South Asian India (South Asia) UKB —
PSS011112 — — 1,428 individuals — South Asian — UKB —
PSS000171 — — 81,423 individuals,
46.0 % Male samples
 Mean = 57.25 years
Range = [39.99, 70.5] years		 European — UKB —
PSS010765 — — 3,652 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010513 — — 6,003 individuals,
55.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010261 — — 2,256 individuals,
45.0 % Male samples
 Mean = 58.0 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS011139 — — 65,814 individuals — European
(white British ancestry)		 — UKB —