Trait: neutrophil percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007990
Description A calculated measurement in which the number of neutrophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • blood neutrophil count to total leukocyte count ratio
  • neutrophil count as percentage of total white blood cells
  • neutrophil count to total WBC count ratio
  • neutrophil percentage
  • neutrophil percentage of white cells
Mapped term CMO:0000370

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000106
(neut_p)
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Neutrophil percentage of white cells neutrophil percentage of leukocytes 22,049
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000106/ScoringFiles/PGS000106.txt.gz
PGS000183
(neut_p)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Neutrophil percentage of white cells neutrophil percentage of leukocytes 437
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000183/ScoringFiles/PGS000183.txt.gz
PGS001077
(GBE_INI30200)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Neutrophill % neutrophil percentage of leukocytes 13,703
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001077/ScoringFiles/PGS001077.txt.gz
PGS001997
(portability-PLR_neutrophil_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Neutrophil percentage neutrophil percentage of leukocytes 65,022
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001997/ScoringFiles/PGS001997.txt.gz
PGS002214
(portability-ldpred2_neutrophil_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Neutrophil percentage neutrophil percentage of leukocytes 769,542
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002214/ScoringFiles/PGS002214.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000244 PGS000106
(neut_p)
 PSS000171|
European Ancestry|
81,423 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Neutrophil percentage of white cells — — Pearson correlation coefficent (r): 0.32169 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000245 PGS000106
(neut_p)
 PSS000145|
European Ancestry|
39,190 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Neutrophil percentage of white cells — — Pearson correlation coefficent (r): 0.31935 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) —
PPM000537 PGS000183
(neut_p)
 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Neutrophil percentage of white cells — — R²: 0.06432 sex, age, 10 genetic PCs —
PPM008143 PGS001077
(GBE_INI30200)
 PSS007001|
African Ancestry|
6,120 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — Incremental R2 (full-covars): 0.01344
R²: 0.04156 [0.03206, 0.05106]
PGS R2 (no covariates): 0.01383 [0.00819, 0.01946]		 age, sex, UKB array type, Genotype PCs —
PPM008144 PGS001077
(GBE_INI30200)
 PSS007002|
East Asian Ancestry|
1,654 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.07662 [0.0524, 0.10084]
Incremental R2 (full-covars): 0.04345
PGS R2 (no covariates): 0.04564 [0.02632, 0.06496]		 age, sex, UKB array type, Genotype PCs —
PPM008145 PGS001077
(GBE_INI30200)
 PSS007003|
European Ancestry|
24,130 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.07418 [0.06792, 0.08044]
Incremental R2 (full-covars): 0.07151
PGS R2 (no covariates): 0.07289 [0.06667, 0.0791]		 age, sex, UKB array type, Genotype PCs —
PPM008146 PGS001077
(GBE_INI30200)
 PSS007004|
South Asian Ancestry|
7,491 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.05036 [0.04093, 0.0598]
Incremental R2 (full-covars): 0.04554
PGS R2 (no covariates): 0.04441 [0.03549, 0.05333]		 age, sex, UKB array type, Genotype PCs —
PPM008147 PGS001077
(GBE_INI30200)
 PSS007005|
European Ancestry|
65,520 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Neutrophill % — — R²: 0.08175 [0.07779, 0.08572]
Incremental R2 (full-covars): 0.07935
PGS R2 (no covariates): 0.07934 [0.07542, 0.08325]		 age, sex, UKB array type, Genotype PCs —
PPM010852 PGS001997
(portability-PLR_neutrophil_perc)
 PSS009254|
European Ancestry|
3,988 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2971 [0.2684, 0.3252] sex, age, birth date, deprivation index, 16 PCs —
PPM010853 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008808|
European Ancestry|
6,413 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2972 [0.2747, 0.3194] sex, age, birth date, deprivation index, 16 PCs —
PPM010854 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008582|
Greater Middle Eastern Ancestry|
1,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2921 [0.2377, 0.3446] sex, age, birth date, deprivation index, 16 PCs —
PPM010855 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008360|
South Asian Ancestry|
6,055 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2672 [0.2436, 0.2904] sex, age, birth date, deprivation index, 16 PCs —
PPM010856 PGS001997
(portability-PLR_neutrophil_perc)
 PSS008137|
East Asian Ancestry|
1,760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2332 [0.1882, 0.2771] sex, age, birth date, deprivation index, 16 PCs —
PPM010857 PGS001997
(portability-PLR_neutrophil_perc)
 PSS007924|
African Ancestry|
2,334 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.166 [0.1261, 0.2054] sex, age, birth date, deprivation index, 16 PCs —
PPM010858 PGS001997
(portability-PLR_neutrophil_perc)
 PSS009028|
African Ancestry|
3,681 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.1587 [0.1269, 0.1901] sex, age, birth date, deprivation index, 16 PCs —
PPM010851 PGS001997
(portability-PLR_neutrophil_perc)
 PSS009480|
European Ancestry|
19,359 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.3059 [0.293, 0.3186] sex, age, birth date, deprivation index, 16 PCs —
PPM012559 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS009480|
European Ancestry|
19,359 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.3042 [0.2913, 0.3169] sex, age, birth date, deprivation index, 16 PCs —
PPM012560 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS009254|
European Ancestry|
3,988 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2993 [0.2707, 0.3274] sex, age, birth date, deprivation index, 16 PCs —
PPM012561 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008808|
European Ancestry|
6,413 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2906 [0.268, 0.3129] sex, age, birth date, deprivation index, 16 PCs —
PPM012562 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008582|
Greater Middle Eastern Ancestry|
1,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2984 [0.2443, 0.3507] sex, age, birth date, deprivation index, 16 PCs —
PPM012563 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008360|
South Asian Ancestry|
6,055 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2641 [0.2405, 0.2874] sex, age, birth date, deprivation index, 16 PCs —
PPM012564 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS008137|
East Asian Ancestry|
1,760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.2471 [0.2025, 0.2907] sex, age, birth date, deprivation index, 16 PCs —
PPM012565 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS007924|
African Ancestry|
2,334 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.1602 [0.1202, 0.1996] sex, age, birth date, deprivation index, 16 PCs —
PPM012566 PGS002214
(portability-ldpred2_neutrophil_perc)
 PSS009028|
African Ancestry|
3,681 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Neutrophil percentage — — Partial Correlation (partial-r): 0.1568 [0.125, 0.1882] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007004 — — 7,491 individuals — South Asian — UKB —
PSS007005 — — 65,520 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009254 — — 3,988 individuals — European Poland (NE Europe) UKB —
PSS008582 — — 1,147 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008808 — — 6,413 individuals — European Italy (South Europe) UKB —
PSS008360 — — 6,055 individuals — South Asian India (South Asia) UKB —
PSS008137 — — 1,760 individuals — East Asian China (East Asia) UKB —
PSS000291 — — 39,260 individuals — European — INTERVAL —
PSS000171 — — 81,423 individuals,
46.0 % Male samples
 Mean = 57.25 years
Range = [39.99, 70.5] years		 European — UKB —
PSS009028 — — 3,681 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009480 — — 19,359 individuals — European UK (+ Ireland) UKB —
PSS000145 — — 39,190 individuals,
50.0 % Male samples
 Mean = 43.83 years
Range = [18.0, 76.4] years		 European — INTERVAL —
PSS007924 — — 2,334 individuals — African American or Afro-Caribbean Carribean UKB —
PSS007001 — — 6,120 individuals — African unspecified — UKB —
PSS007002 — — 1,654 individuals — East Asian — UKB —
PSS007003 — — 24,130 individuals — European non-white British ancestry UKB —