Trait: eosinophil percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007991
Description A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • blood eosinophil count to total leukocyte count ratio
  • eosinophil count as percentage of total white blood cells
  • eosinophil count to total WBC count ratio
  • eosinophil percentage
  • eosinophil percentage of white cells
Mapped term CMO:0000369

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000091
(eo_p)
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Eosinophil percentage of white cells eosinophil percentage of leukocytes 24,406
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000091/ScoringFiles/PGS000091.txt.gz
PGS000166
(eo_p)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Eosinophil percentage of white cells eosinophil percentage of leukocytes 571
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000166/ScoringFiles/PGS000166.txt.gz
PGS001076
(GBE_INI30210)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Eosinophill % eosinophil percentage of leukocytes 12,563
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001076/ScoringFiles/PGS001076.txt.gz
PGS001949
(portability-PLR_log_eosinophil_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Eosinophil percentage eosinophil percentage of leukocytes 9,236
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001949/ScoringFiles/PGS001949.txt.gz
PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Eosinophil percentage eosinophil percentage of leukocytes 593,459
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002167/ScoringFiles/PGS002167.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000214 PGS000091
(eo_p)
 PSS000156|
European Ancestry|
81,283 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Eosinophil percentage of white cells — — Pearson correlation coefficent (r): 0.39099 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000215 PGS000091
(eo_p)
 PSS000130|
European Ancestry|
40,326 individuals
 PGP000051 |
Xu Y et al. Cell Genom (2022)
 Reported Trait: Eosinophil percentage of white cells — — Pearson correlation coefficent (r): 0.37643 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) —
PPM000522 PGS000166
(eo_p)
 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Eosinophil percentage of white cells — — R²: 0.0979 sex, age, 10 genetic PCs —
PPM008138 PGS001076
(GBE_INI30210)
 PSS007006|
African Ancestry|
6,120 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eosinophill % — — R²: 0.02749 [0.01965, 0.03533]
Incremental R2 (full-covars): 0.01358
PGS R2 (no covariates): 0.01502 [0.00915, 0.02088]		 age, sex, UKB array type, Genotype PCs —
PPM008139 PGS001076
(GBE_INI30210)
 PSS007007|
East Asian Ancestry|
1,654 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eosinophill % — — R²: 0.0678 [0.0448, 0.0908]
Incremental R2 (full-covars): 0.03179
PGS R2 (no covariates): 0.03326 [0.01655, 0.04996]		 age, sex, UKB array type, Genotype PCs —
PPM008140 PGS001076
(GBE_INI30210)
 PSS007008|
European Ancestry|
24,130 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eosinophill % — — R²: 0.10724 [0.09998, 0.1145]
Incremental R2 (full-covars): 0.09158
PGS R2 (no covariates): 0.09579 [0.08884, 0.10274]		 age, sex, UKB array type, Genotype PCs —
PPM008141 PGS001076
(GBE_INI30210)
 PSS007009|
South Asian Ancestry|
7,491 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eosinophill % — — R²: 0.08004 [0.06852, 0.09157]
Incremental R2 (full-covars): 0.0618
PGS R2 (no covariates): 0.06258 [0.05219, 0.07296]		 age, sex, UKB array type, Genotype PCs —
PPM008142 PGS001076
(GBE_INI30210)
 PSS007010|
European Ancestry|
65,520 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eosinophill % — — R²: 0.10364 [0.09929, 0.108]
Incremental R2 (full-covars): 0.09566
PGS R2 (no covariates): 0.09594 [0.09171, 0.10016]		 age, sex, UKB array type, Genotype PCs —
PPM010467 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS009442|
European Ancestry|
11,529 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.2072 [0.1897, 0.2246] sex, age, birth date, deprivation index, 16 PCs —
PPM010468 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS009216|
European Ancestry|
2,282 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.2342 [0.1949, 0.2728] sex, age, birth date, deprivation index, 16 PCs —
PPM010469 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS008770|
European Ancestry|
3,365 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1724 [0.1393, 0.2051] sex, age, birth date, deprivation index, 16 PCs —
PPM010470 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS008544|
Greater Middle Eastern Ancestry|
676 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1901 [0.1152, 0.2628] sex, age, birth date, deprivation index, 16 PCs —
PPM010471 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS008322|
South Asian Ancestry|
4,224 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1678 [0.1382, 0.197] sex, age, birth date, deprivation index, 16 PCs —
PPM010472 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS008099|
East Asian Ancestry|
983 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1291 [0.0665, 0.1907] sex, age, birth date, deprivation index, 16 PCs —
PPM010473 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS007886|
African Ancestry|
1,291 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.0617 [0.0067, 0.1162] sex, age, birth date, deprivation index, 16 PCs —
PPM010474 PGS001949
(portability-PLR_log_eosinophil_perc)
 PSS008990|
African Ancestry|
2,100 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.0967 [0.054, 0.1391] sex, age, birth date, deprivation index, 16 PCs —
PPM012184 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS009216|
European Ancestry|
2,282 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.2199 [0.1803, 0.2587] sex, age, birth date, deprivation index, 16 PCs —
PPM012185 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS008770|
European Ancestry|
3,365 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1751 [0.142, 0.2077] sex, age, birth date, deprivation index, 16 PCs —
PPM012186 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS008544|
Greater Middle Eastern Ancestry|
676 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.18 [0.1049, 0.253] sex, age, birth date, deprivation index, 16 PCs —
PPM012187 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS008322|
South Asian Ancestry|
4,224 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1683 [0.1388, 0.1976] sex, age, birth date, deprivation index, 16 PCs —
PPM012188 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS008099|
East Asian Ancestry|
983 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.1159 [0.0531, 0.1778] sex, age, birth date, deprivation index, 16 PCs —
PPM012189 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS007886|
African Ancestry|
1,291 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.0644 [0.0095, 0.119] sex, age, birth date, deprivation index, 16 PCs —
PPM012190 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS008990|
African Ancestry|
2,100 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.091 [0.0482, 0.1335] sex, age, birth date, deprivation index, 16 PCs —
PPM012183 PGS002167
(portability-ldpred2_log_eosinophil_perc)
 PSS009442|
European Ancestry|
11,529 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Eosinophil percentage — — Partial Correlation (partial-r): 0.2043 [0.1867, 0.2217] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007006 — — 6,120 individuals — African unspecified — UKB —
PSS007007 — — 1,654 individuals — East Asian — UKB —
PSS007008 — — 24,130 individuals — European non-white British ancestry UKB —
PSS007009 — — 7,491 individuals — South Asian — UKB —
PSS007010 — — 65,520 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS000291 — — 39,260 individuals — European — INTERVAL —
PSS008770 — — 3,365 individuals — European Italy (South Europe) UKB —
PSS007886 — — 1,291 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008099 — — 983 individuals — East Asian China (East Asia) UKB —
PSS000156 — — 81,283 individuals,
45.0 % Male samples
 Mean = 57.19 years
Range = [38.87, 71.1] years		 European — UKB —
PSS008544 — — 676 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008322 — — 4,224 individuals — South Asian India (South Asia) UKB —
PSS009216 — — 2,282 individuals — European Poland (NE Europe) UKB —
PSS008990 — — 2,100 individuals — African unspecified Nigeria (West Africa) UKB —
PSS000130 — — 40,326 individuals,
49.0 % Male samples
 Mean = 43.83 years
Range = [18.0, 76.4] years		 European — INTERVAL —
PSS009442 — — 11,529 individuals — European UK (+ Ireland) UKB —