Trait: eosinophil percentage of leukocytes

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007991
Description
  • A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes.
Trait category
Hematological measurement
Synonyms 5 synonyms
  • blood eosinophil count to total leukocyte count ratio
  • eosinophil count as percentage of total white blood cells
  • eosinophil count to total WBC count ratio
  • eosinophil percentage
  • eosinophil percentage of white cells
Mapped term(s) CMO:0000369

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000091
(eo_p)
 PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre		 Eosinophil percentage of white cells eosinophil percentage of leukocytes 589
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000091/ScoringFiles/PGS000091.txt.gz
PGS000166
(eo_p)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Eosinophil percentage of white cells eosinophil percentage of leukocytes 571
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000166/ScoringFiles/PGS000166.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000522 PGS000166
(eo_p)
 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Eosinophil percentage of white cells — — R²: 0.0979 sex, age, 10 genetic PCs —
PPM000215 PGS000091
(eo_p)
 PSS000130|
European Ancestry|
40,326 individuals
 PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre		 Reported Trait: Eosinophil percentage of white cells — — Pearson correlation coefficent (r): 0.3412 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) —
PPM000214 PGS000091
(eo_p)
 PSS000156|
European Ancestry|
81,283 individuals
 PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre		 Reported Trait: Eosinophil percentage of white cells — — Pearson correlation coefficent (r): 0.3687 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000156 — — 81,283 individuals,
45.0 % Male samples
 Mean = 57.19 years
Range = [38.87, 71.1] years		 European — UKB —
PSS000130 — — 40,326 individuals,
49.0 % Male samples
 Mean = 43.83 years
Range = [18.0, 76.4] years		 European — INTERVAL —
PSS000291 — — 39,260 individuals — European — INTERVAL —