Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0007991 |
Description | A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes. | Trait category |
Hematological measurement
|
Synonyms |
5 synonyms
|
Mapped term | CMO:0000369 |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | Ancestry distribution | Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000091 (eo_p) |
PGP000051 | Xu Y et al. Cell Genom (2022) |
Eosinophil percentage of white cells | eosinophil percentage of leukocytes | 24,406 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000091/ScoringFiles/PGS000091.txt.gz | |
PGS000166 (eo_p) |
PGP000078 | Vuckovic D et al. Cell (2020) |
Eosinophil percentage of white cells | eosinophil percentage of leukocytes | 571 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000166/ScoringFiles/PGS000166.txt.gz |
PGS001076 (GBE_INI30210) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Eosinophill % | eosinophil percentage of leukocytes | 12,563 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001076/ScoringFiles/PGS001076.txt.gz |
PGS001949 (portability-PLR_log_eosinophil_perc) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Eosinophil percentage | eosinophil percentage of leukocytes | 9,236 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001949/ScoringFiles/PGS001949.txt.gz |
PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Eosinophil percentage | eosinophil percentage of leukocytes | 593,459 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002167/ScoringFiles/PGS002167.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM000214 | PGS000091 (eo_p) |
PSS000156| European Ancestry| 81,283 individuals |
PGP000051 | Xu Y et al. Cell Genom (2022) |
Reported Trait: Eosinophil percentage of white cells | — | — | Pearson correlation coefficent (r): 0.39099 | age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) | UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS) |
PPM000215 | PGS000091 (eo_p) |
PSS000130| European Ancestry| 40,326 individuals |
PGP000051 | Xu Y et al. Cell Genom (2022) |
Reported Trait: Eosinophil percentage of white cells | — | — | Pearson correlation coefficent (r): 0.37643 | age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) | — |
PPM000522 | PGS000166 (eo_p) |
PSS000291| European Ancestry| 39,260 individuals |
PGP000078 | Vuckovic D et al. Cell (2020) |
Reported Trait: Eosinophil percentage of white cells | — | — | R²: 0.0979 | sex, age, 10 genetic PCs | — |
PPM008138 | PGS001076 (GBE_INI30210) |
PSS007006| African Ancestry| 6,120 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Eosinophill % | — | — | R²: 0.02749 [0.01965, 0.03533] Incremental R2 (full-covars): 0.01358 PGS R2 (no covariates): 0.01502 [0.00915, 0.02088] |
age, sex, UKB array type, Genotype PCs | — |
PPM008139 | PGS001076 (GBE_INI30210) |
PSS007007| East Asian Ancestry| 1,654 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Eosinophill % | — | — | R²: 0.0678 [0.0448, 0.0908] Incremental R2 (full-covars): 0.03179 PGS R2 (no covariates): 0.03326 [0.01655, 0.04996] |
age, sex, UKB array type, Genotype PCs | — |
PPM008140 | PGS001076 (GBE_INI30210) |
PSS007008| European Ancestry| 24,130 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Eosinophill % | — | — | R²: 0.10724 [0.09998, 0.1145] Incremental R2 (full-covars): 0.09158 PGS R2 (no covariates): 0.09579 [0.08884, 0.10274] |
age, sex, UKB array type, Genotype PCs | — |
PPM008141 | PGS001076 (GBE_INI30210) |
PSS007009| South Asian Ancestry| 7,491 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Eosinophill % | — | — | R²: 0.08004 [0.06852, 0.09157] Incremental R2 (full-covars): 0.0618 PGS R2 (no covariates): 0.06258 [0.05219, 0.07296] |
age, sex, UKB array type, Genotype PCs | — |
PPM008142 | PGS001076 (GBE_INI30210) |
PSS007010| European Ancestry| 65,520 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Eosinophill % | — | — | R²: 0.10364 [0.09929, 0.108] Incremental R2 (full-covars): 0.09566 PGS R2 (no covariates): 0.09594 [0.09171, 0.10016] |
age, sex, UKB array type, Genotype PCs | — |
PPM010467 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS009442| European Ancestry| 11,529 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.2072 [0.1897, 0.2246] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010468 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS009216| European Ancestry| 2,282 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.2342 [0.1949, 0.2728] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010469 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS008770| European Ancestry| 3,365 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1724 [0.1393, 0.2051] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010470 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS008544| Greater Middle Eastern Ancestry| 676 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1901 [0.1152, 0.2628] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010471 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS008322| South Asian Ancestry| 4,224 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1678 [0.1382, 0.197] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010472 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS008099| East Asian Ancestry| 983 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1291 [0.0665, 0.1907] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010473 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS007886| African Ancestry| 1,291 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.0617 [0.0067, 0.1162] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM010474 | PGS001949 (portability-PLR_log_eosinophil_perc) |
PSS008990| African Ancestry| 2,100 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.0967 [0.054, 0.1391] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012184 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS009216| European Ancestry| 2,282 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.2199 [0.1803, 0.2587] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012185 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS008770| European Ancestry| 3,365 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1751 [0.142, 0.2077] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012186 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS008544| Greater Middle Eastern Ancestry| 676 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.18 [0.1049, 0.253] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012187 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS008322| South Asian Ancestry| 4,224 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1683 [0.1388, 0.1976] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012188 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS008099| East Asian Ancestry| 983 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.1159 [0.0531, 0.1778] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012189 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS007886| African Ancestry| 1,291 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.0644 [0.0095, 0.119] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012190 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS008990| African Ancestry| 2,100 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.091 [0.0482, 0.1335] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM012183 | PGS002167 (portability-ldpred2_log_eosinophil_perc) |
PSS009442| European Ancestry| 11,529 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Eosinophil percentage | — | — | Partial Correlation (partial-r): 0.2043 [0.1867, 0.2217] | sex, age, birth date, deprivation index, 16 PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS007006 | — | — | 6,120 individuals | — | African unspecified | — | UKB | — |
PSS007007 | — | — | 1,654 individuals | — | East Asian | — | UKB | — |
PSS007008 | — | — | 24,130 individuals | — | European | non-white British ancestry | UKB | — |
PSS007009 | — | — | 7,491 individuals | — | South Asian | — | UKB | — |
PSS007010 | — | — | 65,520 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
PSS000291 | — | — | 39,260 individuals | — | European | — | INTERVAL | — |
PSS008770 | — | — | 3,365 individuals | — | European | Italy (South Europe) | UKB | — |
PSS007886 | — | — | 1,291 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
PSS008099 | — | — | 983 individuals | — | East Asian | China (East Asia) | UKB | — |
PSS000156 | — | — | 81,283 individuals, 45.0 % Male samples |
Mean = 57.19 years Range = [38.87, 71.1] years |
European | — | UKB | — |
PSS008544 | — | — | 676 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
PSS008322 | — | — | 4,224 individuals | — | South Asian | India (South Asia) | UKB | — |
PSS009216 | — | — | 2,282 individuals | — | European | Poland (NE Europe) | UKB | — |
PSS008990 | — | — | 2,100 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
PSS000130 | — | — | 40,326 individuals, 49.0 % Male samples |
Mean = 43.83 years Range = [18.0, 76.4] years |
European | — | INTERVAL | — |
PSS009442 | — | — | 11,529 individuals | — | European | UK (+ Ireland) | UKB | — |